Review of Alterations in Endothelial Nitric Oxide Production in Diabetes

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance.

1996 • 1,695 citations

Identification of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factors

1996 • 1,226 citations

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

1994 • 1,200 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

1993 • 1,102 citations

Hyperglycemic Pseudohypoxia and Diabetic Complications

1993 • 1,025 citations

Impaired Neurogenic and Endothelium-Mediated Relaxation of Penile Smooth Muscle from Diabetic Men with Impotence

1989 • 960 citations

Impaired endothelium-dependent and independent vasodilation in patients with Type 2 (non-insulin-dependent) diabetes mellitus

1992 • 922 citations

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

1996 • 884 citations

High Glucose Increases Nitric Oxide Synthase Expression and Superoxide Anion Generation in Human Aortic Endothelial Cells

1997 • 765 citations

Nitric oxide release accounts for insulin's vascular effects in humans.

1994 • 747 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

Free radicals mediate endothelial cell dysfunction caused by elevated glucose

1992 • 566 citations

Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes.

1992 • 527 citations

Endothelium-Dependent Hyperpolarization

1995 • 523 citations

Inhibition of nitric oxide synthesis by methylene blue

1993 • 519 citations

Impairment of Coronary Vascular Reserve and ACh-Induced Coronary Vasodilation in Diabetic Patients With Angiographically Normal Coronary Arteries and Normal Left Ventricular Systolic Function

1993 • 443 citations

Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels

1996 • 416 citations

Insulin Secretion from Pancreatic B Cells Caused by L-Arginine-Derived Nitrogen Oxides

1992 • 415 citations

Vascular Effects of Acute Hyperglycemia in Humans Are Reversed by <scp>l</scp> -Arginine

1997 • 362 citations

Attenuation of endothelium-dependent relaxation in aorta from diabetic rats

1986 • 350 citations

Impairment of endothelium‐dependent relaxation and changes in levels of cyclic GMP in aorta from streptozotocin‐induced diabetic rats

1989 • 294 citations

Prevention of Diabetic Vascular Dysfunction by Guanidines: Inhibition of Nitric Oxide Synthase Versus Advanced Glycation End-Product Formation

1993 • 289 citations

Chronic Hyperglycemia Impairs Endothelial Function and Insulin Sensitivity Via Different Mechanisms in Insulin-Dependent Diabetes Mellitus

1996 • 284 citations

Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta

1991 • 283 citations

L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits.

1990 • 278 citations

Responses of the skin microcirculation to acetylcholine and sodium nitroprusside in patients with NIDDM

1995 • 265 citations

DISFUNCTION OF VASCULAR ENDOTHELIUM IN DIABETES MELLITUS

1993 • 259 citations

Impairment of endothelium‐dependent relaxation in aortae from spontaneously diabetic rats

1988 • 255 citations

Plasma Amino Acid Levels in Diabetic Ketoacidosis

1970 • 248 citations

Contraction of diabetic rabbit aorta caused by endothelium-derived PGH2-TxA2

1989 • 245 citations

The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: A pet study

1995 • 237 citations

Acute Amelioration of Diabetic Endothelial Dysfunction with a Derivative of the Nitric Oxide Synthase Cofactor, Tetrahydrobiopterin

1997 • 224 citations

Endothelium-Mediated Vascular Function in Insulin-Dependent Diabetes Mellitus

1995 • 220 citations

Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus.

1997 • 220 citations

Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: Role of polyol pathway

1992 • 216 citations

Inhibition of Nitric Oxide Synthesis in Forearm Vasculature of Insulin-Dependent Diabetic Patients: Blunted Vasoconstriction in Patients with Microalbuminuria

1993 • 214 citations

Role of EDRF (nitric oxide) in diabetic renal hyperfiltration

1993 • 211 citations

Impaired Endothelium-Dependent and Independent Dilatation of Forearm Resistance Arteries in Men with Diet-Treated Non-Insulin-Dependent Diabetes: Role of Dyslipidaemia

1996 • 204 citations

Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: role of free radicals

1994 • 198 citations

Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta

1988 • 193 citations

The dopamine autoreceptor agonist B-HT 920 stimulates denervated postsynaptic brain dopamine receptors in rodent and primate models of Parkinson's disease: a novel approach to treatment

1986 • 183 citations

Reduction of penile nitric oxide synthase in diabetic BB/WORdp (type I) and BBZ/WORdp (type II) rats with erectile dysfunction.

1995 • 182 citations

Interactions between L-arginine and L-glutamine change endothelial NO production. An effect independent of NO synthase substrate availability.

1995 • 182 citations

Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals

1997 • 180 citations

Mechanism of impaired responses of cerebral arterioles during diabetes mellitus

1991 • 179 citations

Normalization of Diacylglycerol-Protein Kinase C Activation by Vitamin E in Aorta of Diabetic Rats and Cultured Rat Smooth Muscle Cells Exposed to Elevated Glucose Levels

1994 • 170 citations

Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals

1992 • 161 citations

Amelioration by L-Arginine of a Dysfunctional Arginine/Nitric Oxide Pathway in Diabetic Endothelium

1995 • 161 citations

Methylene blue inhibits vasodilation of skeletal muscle arterioles to acetylcholine and nitric oxide via the extracellular generation of superoxide anion.

1990 • 159 citations

Alterations in endothelium‐dependent hyperpolarization and relaxation in mesenteric arteries from streptozotocin‐induced diabetic rats

1997 • 159 citations

Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant

1995 • 157 citations

Activation of L‐arginine transport (system y+) and nitric oxide synthase by elevated glucose and insulin in human endothelial cells.

1996 • 154 citations

Endothelium-Dependent Relaxation in Aorta of BB Rat

1987 • 151 citations

Topical hyperglycemia rapidly suppresses EDRF-mediated vasodilation of normal rat arterioles

1993 • 144 citations

Endothelium-Dependent and -Independent Vasodilation of Large Arteries in Normoalbuminuric Insulin-Dependent Diabetes Mellitus

1996 • 142 citations

Endothelium and inelastic arteries: an early marker of vascular dysfunction in non-insulin dependent diabetes

1996 • 141 citations

Possible superoxide radical-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats.

1993 • 141 citations

Impaired Contraction and Endothelium-Dependent Relaxation in Isolated Resistance Vessels from Patients with Insulin-Dependent Diabetes Mellitus

1994 • 139 citations

Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response.

1994 • 128 citations

Role of Endothelium-Derived Nitric Oxide in the Pathogenesis of the Renal Hemodynamic Changes of Experimental Diabetes

1994 • 125 citations

Endothelium-Dependent Vascular Relaxation in Patients With Type I Diabetes

1993 • 124 citations

The effect of hyperglycaemia on function of rat isolated mesenteric resistance artery

1994 • 121 citations

Abnormal renal hemodynamic response to reduced renal perfusion pressure in diabetic rats: role of NO

1993 • 121 citations

Plasma and vascular tissue arginine are decreased in diabetes: acute arginine supplementation restores endothelium-dependent relaxation by augmenting cGMP production.

1997 • 120 citations

Nitric oxide generation from streptozotocin ¹

1994 • 119 citations

Oxygen transport impairment in diabetes.

1976 • 117 citations

A Contrasting effect of the diabetic state upon the contractile responses of aortic preparations from the rat and rabbit

1987 • 115 citations

Diverse prostaglandin receptors activate distinct signal transduction pathways in rat myometrium

1992 • 115 citations

Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide.

1992 • 115 citations

Noninvasive Detection of Functional Alterations of the Arterial Wall in IDDM Patients With and Without Microalbuminuria

1995 • 113 citations

Nitric Oxide and Ocular Blood Flow in Patients With IDDM

1997 • 111 citations

Changes in superoxide dismutase mRNA expression by streptozotocin‐induced diabetes

1996 • 108 citations

Diabetes-induced endothelial dysfunction in streptozotocin-treated rats

1993 • 106 citations

Nonendothelial‐derived nitric oxide activates the ATP‐sensitive K⁺ channel of vascular smooth muscle cells

1994 • 106 citations

Diabetes‐induced activation of system y+ and nitric oxide synthase in human endothelial cells: association with membrane hyperpolarization.

1995 • 103 citations

Impaired vasoreactivity to nitric oxide in experimental diabetic neuropathy

1995 • 103 citations

Cardiovascular Significance of Endothelium-Derived Vasoactive Factors

1992 • 97 citations

Aldose Reductase Inhibition Restores Endothelial Cell Function in Diabetic Rabbit Aorta

1993 • 95 citations

Vascular Effects of l-Arginine: Anything beyond a Substrate for the NO-Synthase?

1997 • 94 citations

L-arginine administration prevents glomerular hyperfiltration and decreases proteinuria in diabetic rats.

1993 • 94 citations

Dilation of isolated skeletal muscle arterioles by insulin is endothelium dependent and nitric oxide mediated

1996 • 94 citations

Impairment of endothelium-dependent dilatation of the basilar artery during diabetes mellitus

1992 • 93 citations

Prevention by insulin treatment of endothelial dysfunction but not enhanced noradrenaline‐induced contractility in mesenteric resistance arteries from streptozotocin‐induced diabetic rats

1994 • 92 citations

Forearm Nitric Oxide Balance, Vascular Relaxation, and Glucose Metabolism in NIDDM Patients

1997 • 92 citations

Brain uptake and release of amino acids in nondiabetic and insulin-dependent diabetic subjects: Important role of glutamine release for nitrogen balance

1992 • 91 citations

Impaired endothelium‐dependent relaxation in isolated resistance arteries of spontaneously diabetic rats

1995 • 91 citations

Superoxide dismutase restores the influence of nitric oxide on renal arterioles in diabetes mellitus.

1995 • 90 citations

High Glucose Concentrations Dilate Cerebral Arteries and Diminish Myogenic Tone Through an Endothelial Mechanism

1997 • 90 citations

Association of gestational diabetes with abnormal maternal vascular endothelial function

1997 • 89 citations

Modulation of vascular tonus by the endothelium in experimental diabetes

1987 • 88 citations

Effects of experimental diabetes on the responsiveness of rat aorta

1989 • 88 citations

Functional changes in vascular smooth muscle and endothelium of arteries during diabetes mellitus

1992 • 87 citations

Impaired arginine metabolism and NO synthesis in coronary endothelial cells of the spontaneously diabetic BB rat

1995 • 86 citations

Bioassay of endothelium-derived relaxing factor in diabetic rat aorta

1992 • 86 citations

Effects of low‐dose <scp>l</scp>‐arginine on insulin‐mediated vasodilatation and insulin sensitivity

1997 • 84 citations

Arginine analogues inhibit responses mediated by ATP-sensitive K+ channels

1996 • 83 citations

Selective impairment of hindquarters vasodilator responses to bradykinin in conscious Wistar rats with streptozotocin‐induced diabetes mellitus

1991 • 83 citations

Structural and functional origins of suppressed acetylcholine vasodilation in diabetic rat intestinal arterioles.

1991 • 83 citations

Exposure To Elevated <scp>D</scp>-Glucose Concentrations Modulates Vascular Endothelial Cell Vasodilatory Response

1993 • 82 citations

Reversal by L-arginine of a dysfunctional arginine/nitric oxide pathway in the endothelium of the genetic diabetic BB rat

1997 • 77 citations

Characteristics of coronary endothelial dysfunction in experimental diabetes

1997 • 77 citations

Role of Prostaglandin H2 as an Endothelium-Derived Contracting Factor in Diabetic State

1993 • 73 citations

Expression of inducible nitric oxide synthase in placenta of women with gestational diabetes

1996 • 72 citations

The Diabetic Heart

1991 • 71 citations

Vascular and Hormonal Responses to Arginine: Provision of Substrate for Nitric Oxide or Non-Specific Effect?

1995 • 71 citations

l-Arginine Reduces Lipid Peroxidation in Patients with Diabetes Mellitus

1997 • 71 citations

Selective Impairment of Acetylcholine-Mediated Endothelium-Dependent Relaxation in Isolated Resistance Arteries of the Streptozotocin-Induced Diabetic Rat

1995 • 70 citations

Short-term oral administration of l-arginine reverses defective endothelium-dependent relaxation and cGMP generation in diabetes

1996 • 69 citations

Renal Effects of Acute and Chronic Nitric Oxide Inhibition in Experimental Diabetes

1996 • 68 citations

Decrease in endothelium-dependent relaxation and levels of cyclic nucleotides in aorta from rabbits with alloxan-induced diabetes.

1990 • 67 citations

Evaluation of the mechanism of endothelial dysfunction in the genetically-diabetic BB rat

1996 • 66 citations

Endothelial dysfunction of conduit arteries in insulin-dependent diabetes mellitus without microalbuminuria

1997 • 65 citations

Impaired microvascular response to graded coronary occlusion in diabetic and hyperglycemic dogs

1995 • 64 citations

Plasma Endothelin Levels and Vascular Effects of Intravenous <scp>l</scp>-Arginine Infusion in Subjects with Uncomplicated Insulin-Dependent Diabetes Mellitus

1994 • 63 citations

Endothelium‐dependent increase in vascular sensitivity to phenylephrine in long‐term streptozotocin diabetic rat aorta

1992 • 62 citations

Alterations of intrarenal renin-angiotensin and nitric oxide systems in streptozotocin-induced diabetic rats.

1997 • 62 citations

Role of Nitric Oxide, Adenosine, and ATP-Sensitive Potassium Channels in Insulin-Induced Vasodilation

1996 • 61 citations

Acute effects of glucose on reactivity of cerebral microcirculation: role of activation of protein kinase C

1995 • 61 citations

Differential Regulation of <scp>l</scp> -Arginine Transport and Nitric Oxide Production by Vascular Smooth Muscle and Endothelium

1996 • 61 citations

Increased vasodilator response to acetylcholine of renal blood vessels from diabetic rats

1988 • 60 citations

Contraction and relaxation of aortas from diabetic rats: effects of chronic anti-oxidant and aminoguanidine treatments

1996 • 59 citations

L-arginine reduces heart collagen accumulation in the diabetic db/db mouse.

1994 • 58 citations

Interference of glycosylated human hemoglobin with endothelium-dependent responses.

1993 • 58 citations

Local 24-h hyperglycemia does not affect endothelium-dependent or -independent vasoreactivity in humans

1996 • 58 citations

Attenuated glomerular cGMP production and renal vasodilation in streptozotocin-induced diabetic rats

1993 • 58 citations

Effect of diabetes mellitus on response of the basilar artery to activation of ATP-sensitive potassium channels

1994 • 57 citations

Nitric oxide in ischaemic acute renal failure of streptozotocin diabetic rats

1996 • 57 citations

Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes

1989 • 55 citations

L-arginine for testing endothelium-dependent vascular functions in health and disease.

1997 • 55 citations

Impairment of endothelium dependent relaxation in the diabetic rat heart: mechanisms and implications

1996 • 54 citations

Pathophysiology of Microvascular Disease in Non-Insulin-Dependent Diabetes

1995 • 52 citations

Effects of streptozotocin-diabetes on sympathetic nerve, endothelial and smooth muscle function in the rat mesenteric arterial bed

1995 • 51 citations

&lt;i&gt;L&lt;/i&gt;-Arginine Does Not Restore Endothelial Dysfunction in Atherosclerotic Rabbit Aorta in vitro

1991 • 50 citations

Active and Passive Mechanical Properties of Isolated Arterioles From STZ-Induced Diabetic Rats: Effect of Aminoguanidine Treatment

1994 • 49 citations

Decreased cerebral blood flow during acute hyperglycemia

1995 • 49 citations

Reduced high-energy phosphate levels in rat hearts. I. Effects of alloxan diabetes

1976 • 48 citations

Adenylate and guanylate cyclase activity in the penis and aorta of the diabetic rat: an in vitro study

1994 • 47 citations

Syngeneic Pancreatic Islet Transplantation Reverses Endothelial Dysfunction in Experimental Diabetes

1995 • 42 citations

Endothelial-dependent vasodilation is preserved in non-insulin-dependent Zucker fatty diabetic rats

1995 • 42 citations

Control of late G0/G1 progression and protein modification by SmC/IGF I

1987 • 42 citations

Protein kinase C suppresses receptor-mediated pial arteriolar relaxation in the diabetic rat

1994 • 40 citations

Changes in Vascular Reactivity in Experimental Diabetic Rats: Comparison with Hypothyroid Rats

1988 • 40 citations

Impairment of endothelium‐dependent but not of endothelium‐independent dilatation in guinea‐pig aorta rings incubated in the presence of elevated glucose

1997 • 39 citations

Expression of nitric oxide synthase in macula densa in streptozotocin diabetic rats

1996 • 38 citations

Regional amino acid transport into brain during diabetes: effect of plasma amino acids

1987 • 38 citations

Diminished muscarinic receptor-mediated cerebral blood flow response in streptozotocin-treated rats

1992 • 38 citations

Endothelium-derived hyperpolarizing factor does not contribute to the decrease in endothelium-dependent relaxation in the aorta of streptozotocin-induced diabetic rats

1995 • 37 citations

The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats

1994 • 37 citations

Impairment of Coronary Blood Flow Regulation by Endothelium-Derived Nitric Oxide in Dogs with Alloxan-Induced Diabetes

1996 • 37 citations

Plasma Amino Acids in Relation to Metabolic Control in Insulin‐Dependent Diabetic Children

1989 • 37 citations

Altered microvascular reactivity to endothelin‐1, endothelin‐3 and N^G‐nitro‐L‐arginine methyl ester in streptozotocin‐induced diabetes mellitus

1992 • 36 citations

Influence of experimental diabetes on the mechanical responses of canine coronary arteries: role of endothelium

1988 • 36 citations

Endothelial function and adrenergic reactivity in human type-II diabetic resistance arteries

1996 • 36 citations

Glucose elevations alter bradykinin-stimulated intracellular calcium accumulation in cultured endothelial cells

1997 • 36 citations

Effects of non-insulin dependent diabetes mellitus on the reactivity of human internal mammary artery and human saphenous vein

1995 • 35 citations

L-arginine analogues blunt prostaglandin-related dilation of arterioles

1993 • 35 citations

Supersensitivity and Endothelium Dependency of Histamine-induced Relaxation in Mesenteric Arteries Isolated from Diabetic Rats

1986 • 35 citations

Impaired nitric oxide release by glomeruli from diabetic rats

1995 • 35 citations

<scp>l</scp> -Arginine Restores Dilator Responses of the Basilar Artery to Acetylcholine During Chronic Hypertension

1996 • 34 citations

Terbium, a Fluorescent Probe for Insulin Receptor Binding: Evidence for a Conformational Change in the Receptor Protein Due to Insulin Binding

1984 • 34 citations

Defective endothelium-dependent relaxation in the JCR:LA-corpulent rat.

1994 • 34 citations

Preservation of endothelium‐dependent relaxation in cholesterol‐fed and streptozotocin‐induced diabetic mice by the chronic administration of cholestyramine

1996 • 33 citations

Hyperglycemia Increased the Responsiveness of Isolated Rabbit&amp;rsquo;s Pulmonary Arterial Rings to Serotonin

1996 • 33 citations

Age-related changes in endothelium-dependent relaxation in aorta from genetically diabetic WBN/Kob rats

1992 • 32 citations

Abnormal Rheologic Effects of Glyceryl Trinitrate in Patients with Non-Insulin-Dependent Diabetes Mellitus and Reversal by Antioxidants

1995 • 32 citations

Diabetes and insulin‐induced stimulation of L‐arginine transport and nitric oxide synthesis in rabbit isolated gastric glands.

1997 • 31 citations

Primary nitrate tolerance in diabetes mellitus

1994 • 31 citations

Nitric Oxide in Streptozotocin-Induced Diabetes Mellitus in Rats

1996 • 30 citations

Deficient nitric oxide responsible for reduced nerve blood flow in diabetic rats: effects of L‐NAME, L‐arginine, sodium nitroprusside and evening primrose oil

1996 • 30 citations

The effect of insulin treatment and of islet transplantation on the resistance artery function in the STZ‐induced diabetic rat

1996 • 29 citations

Effects of Streptozotocin-Induced Diabetes on Vascular Reactivity in Genetically Hyperinsulinaemic Obese Zucker Rats

1996 • 28 citations

High-glucose incubation of human umbilical-vein endothelial cells does not alter expression and function either of G-protein α-subunits or of endothelial NO synthase

1996 • 28 citations

Effects of the natural flavonoid delphinidin on diabetic microangiopathy.

1995 • 28 citations

In vivo and in vitro evidence of altered nitric oxide metabolism in the spontaneously diabetic, insulin‐dependent BB/Edinburgh rat

1997 • 28 citations

Use of a nitronyl nitroxide to discriminate the contribution of nitric oxide radical in endothelium-dependent relaxation of control and diabetic blood vessels.

1997 • 27 citations

Endothelial dysfunction in the perfused kidney from the streptozotocin-induced diabetic rat.

1997 • 27 citations

Characterization of NADPH diaphorase activity in rat sympathetic autonomic ganglia—effect of diabetes and aging

1993 • 26 citations

L-Arginine Does Not Restore Dilatation of the Basilar Artery during Diabetes Mellitus

1996 • 26 citations

Endothelium-dependent vasodilator responses of the isolated mesenteric bed are preserved in long-term streptozotocin diabetic rats

1993 • 26 citations

Alloxan diabetes alters the rabbit transarterial wall oxygen gradient

1993 • 25 citations

Microvascular responses in the skeletal muscle of the diabetic rat

1996 • 23 citations

&lt;i&gt;L&lt;/i&gt;-Arginine Reduces Glomerular Basement Membrane Collagen N&amp;#949;-Carboxymethyllysine in the Diabetic db/db Mouse

1992 • 23 citations

L-Arginine inhibits in vitro nonenzymatic glycation and advanced glycosylated end product formation of human serum albumin

1996 • 22 citations

Acetylcholine induces vasoconstriction in the microcirculation of cardiomyopathic hamsters: Reversal by L-arginine

1992 • 21 citations

Different mechanisms of l-arginine induced dilation of brain arterioles in normotensive and hypertensive rats

1995 • 21 citations

Impaired Vasodilator Response to Atrial Natriuretic Factor in IDDM

1993 • 20 citations

Effect of Endothelium on Diabetes-Induced Changes in Constrictor Responses Mediated by 5-Hydroxytryptamine in Rat Aorta

1993 • 20 citations

Transport of L-Arginine in Arginine-Deprived Endothelial Cells

1995 • 19 citations

Fosinopril Improves Regulation of Vascular Tone in Mesenteric Bed of Diabetic Rats

1996 • 19 citations

Age-Related Changes in Vascular Reactivity in Genetically Diabetic Rats

1995 • 19 citations

Ramipril prevents hypersensitivity to phenylephrine in aorta from streptozotocin-induced diabetic rats

1994 • 19 citations

Effects of chronic diabetes on the responsiveness to endothelin-1 and other agents of rat atria and thoracic aorta

1994 • 19 citations

Effects of glycosylated hemoglobin on vascular responses in vitro

1997 • 17 citations

Binding and effects of P1075, an opener of ATP-sensitive K+ channels, in the aorta from streptozotocin-treated diabetic rats

1997 • 16 citations

Changes in responsiveness of the aorta to vasorelaxant agents in genetically diabetic rats: A study in WBN/KOB rats

1992 • 16 citations

Venous compliance and the venodilatory effect of nitroglycerin in insulin‐dependent diabetic patients with and without (incipient) nephropathy

1994 • 15 citations

Altered Responsiveness of Diabetic Dog Renal Arteries to Acetylcholine and Phenylephrine: Role of Endothelium

1989 • 15 citations

Impairment of endothelium-dependent relaxation of the isolated basilar artery from streptozotocin-induced diabetic rats.

1996 • 14 citations

Influence of chronic exposure to high concentrations of D-glucose and long-term beta-blocker treatment on intracellular calcium concentrations of porcine aortic endothelial cells.

1998 • 14 citations

Effects of diabetes and uremia on mesenteric vascular reactivity

1996 • 14 citations

L-Arginine Reduces Kidney Collagen Accumulation and N- -(carboxymethyl)lysine in the Aging NMRI-Mouse

1994 • 14 citations

Effect of &lt;i&gt;L&lt;/i&gt;-Arginíne on Reactivity of Hamster Cheek Pouch Arterioles during Diabetes mellitus

1997 • 13 citations

Influence of Nitric Oxide on Luminol-Enhanced Chemiluminescence Measured from Porcine-Stimulated Leukocytes

1997 • 13 citations

Pancreatic transplantation reverses endothelial dysfunction in experimental diabetes mellitus

1998 • 13 citations

Involvement of the L‐arginine‐nitric oxide pathway in hyperglycaemia‐induced coronary artery dysfunction of isolated guinea pig hearts

1996 • 13 citations

Impairment of endothelium-dependent relaxation of superior mesenteric artery in genetically diabetic WBN/Kob rats

1993 • 12 citations

Cerebrovascular responsiveness to N^G‐nitro‐L‐arginine methyl ester in spontaneously diabetic rats

1996 • 12 citations

Effects of HOE 140 on Some Renal Functions in Type I Diabetic Mice

1996 • 11 citations

Vascular reactivity and platelet aggregability during the first five years of insulin‐dependent diabetes in children

1997 • 11 citations

Impaired arterial but not venous responsiveness to nitroglycerin in non‐insulin‐dependent diabetes mellitus

1997 • 9 citations

Parallel regulation of arginine transport and nitric oxide synthesis by angiotensin II in vascular smooth muscle cells role of protein kinase C

1996 • 7 citations

Polyamine transport and arginine pool size in vascular endothelial cells

1994 • 6 citations

Elevation of D-glucose impairs coronary artery autoregulation after slight reduction of coronary flow

1995 • 6 citations

Effects of Hyperglycemia on Vascular Endothelium Nitric Oxide Metabolism

1996 • 6 citations

Attenuation of Depressor Response Induced by Platelet Activating Factor and Acetylcholine in Streptozotocin-Induced Diabetic Rats.

1991 • 5 citations

(Prog. Lipid Res., 25:499-501)Increased release of prostaglandins from the mesenteric vascular bed in streptozotocin diabetes

1986 • 2 citations

German science in danger as hope for big increase fades

1988 • 1 citations

Increased release of prostaglandins from the mesenteric vascular bed in streptozotocin diabetes

1986 • 1 citations

Deleted Work

1955 • 0 citations