Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

1988 • 2,527 citations

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

1986 • 2,422 citations

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

1989 • 1,837 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide

1990 • 1,284 citations

Aminoguanidine Prevents Diabetes-Induced Arterial Wall Protein Cross-Linking

1986 • 1,154 citations

Structure Elucidation of a Senescence Cross-Link from Human Extracellular Matrix

1989 • 1,056 citations

Nonenzymatic Glycosylation and the Pathogenesis of Diabetic Complications

1984 • 1,012 citations

Impaired Neurogenic and Endothelium-Mediated Relaxation of Penile Smooth Muscle from Diabetic Men with Impotence

1989 • 960 citations

The Role of Endothelium in the Responses of Vascular Smooth Muscle to Drugs

1984 • 937 citations

Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase

1987 • 896 citations

Nonenzymatic Browning in Vivo: Possible Process for Aging of Long-Lived Proteins

1981 • 754 citations

Accelerated age-related browning of human collagen in diabetes mellitus.

1984 • 671 citations

Relation between Complications of Type I Diabetes Mellitus and Collagen-Linked Fluorescence

1986 • 579 citations

Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.

1987 • 534 citations

NG-methylarginine, and inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: Does nitric oxide regulate blood pressure in vivo?

1989 • 438 citations

Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells.

1989 • 405 citations

Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta.

1990 • 375 citations

The loss of endothelium-dependent vascular relaxation in hypertension.

1986 • 372 citations

Aging of proteins: isolation and identification of a fluorescent chromophore from the reaction of polypeptides with glucose.

1984 • 372 citations

Attenuation of endothelium-dependent relaxation in aorta from diabetic rats

1986 • 350 citations

Glucosylation of human collagen in aging and diabetes mellitus.

1980 • 208 citations

Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators

1989 • 166 citations

Sodium-volume factor, cardiovascular reactivity and hypotensive mechanism of diuretic therapy in mild hypertension associated with diabetes mellitus

1979 • 159 citations

Endothelium-Dependent Relaxation in Aorta of BB Rat

1987 • 151 citations

Detection of d-glucose-derived pyrrole compounds during maillard reaction under physiological conditions

1987 • 126 citations

Pressor factors and responsiveness in hypertension accompanying diabetes mellitus.

1985 • 119 citations

The chemistry of the Maillard reaction under physiological conditions: a review.

1989 • 116 citations

ε-Amino-Lysine-Bound Glucose in Human Tissues Obtained at Autopsy: Increase in Diabetes Mellitus

1982 • 111 citations

Detection of an advanced glycosylation product bound to protein in situ.

1985 • 106 citations

Advanced glycosylation end-products in experimental murine diabetic nephropathy: effect of islet isografting and of aminoguanidine.

1989 • 94 citations

Chemical Pathways of the Maillard Reaction

1990 • 83 citations

Endothelium-dependent relaxation in aorta of BB rat

1987 • 76 citations

Novel pyrroles from sulfite-inhibited Maillard reactions: insight into the mechanism of inhibition

1988 • 74 citations

[7] Measurement of nonenzymatic protein glycosylation

1984 • 56 citations

Collagen crosslinks: Isolation of reduced Nϵ-hexosylhydroxylysine from borohydride-reduced calf skin insoluble collagen

1972 • 54 citations

Determination of the Oil/ Water Distribution Coefficients of Glyceryl Trinitrate and Two Similar Nitrate Esters

1963 • 54 citations

Aging reduces venous distensibility and the venodilatory response to nitroglycerin in normal subjects

1989 • 49 citations

epsilon-Amino-lysine-bound glucose in human tissues obtained at autopsy. Increase in diabetes mellitus

1982 • 45 citations

Reaction between Glycine and the Hexose Phosphates

1953 • 34 citations

Non-enzymatic glycosylation of tissue protein in diabetes in the rat

1983 • 27 citations

Decreased vascular sensitivity to histamine during aging

1984 • 9 citations