The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production.

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

Introduction of soluble protein into the class I pathway of antigen processing and presentation

1988 • 1,105 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients.

1990 • 807 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.

1991 • 641 citations

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

1993 • 625 citations

Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages.

1993 • 540 citations

Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.

1990 • 487 citations

Th1 And Th2 Cells: Different Patterns Of Lymphokine Secretion Lead To Different Functional Properties

1989 • 460 citations

Antigen-driven bystander suppression after oral administration of antigens.

1991 • 438 citations

Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.

1990 • 414 citations

Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells.

1988 • 389 citations

Presentation of Exogenous Antigen with Class I Major Histocompatibility Complex Molecules

1990 • 338 citations

Functions of Rat T‐Lymphocyte Subsets Isolated by Means of Monoclonal Antibodies

1983 • 330 citations

Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways.

1991 • 316 citations

MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations.

1988 • 285 citations

Inhibition of specific IgE responses in mice by pre-exposure to inhaled antigen.

1981 • 229 citations

Primary sensitisation to inhalant allergens during infancy

1990 • 176 citations

Defence against allergic sensitization in the healthy lung: the role of inhalation tolerance

1989 • 164 citations

INDUCTION OF LONG-TERM SPECIFIC TOLERANCE TO ALLOGRAFTS IN RATS BY THERAPY WITH AN ANTI-CD3-LIKE MONOCLONAL ANTIBODY

1993 • 144 citations

A Contiguous Network of Dendritic Antigen-Presenting Cells within the Respiratory Epithelium

1990 • 144 citations

Mechanisms of mouse spleen dendritic cell function in the generation of influenza-specific, cytolytic T lymphocytes.

1992 • 128 citations

Purification of human C3b inactivator by monoclonal-antibody affinity chromatography

1982 • 122 citations

Orally inducible immune unresponsiveness is abrogated by IFN-gamma treatment.

1990 • 113 citations

Induction of IgE-secreting cells and IgE isotype-specific suppressor T cells in the respiratory lymph nodes of rats in response to antigen inhalation

1985 • 109 citations

Major histocompatibility complex-expressing nonhematopoietic astroglial cells prime only CD8+ T lymphocytes: astroglial cells as perpetuators but not initiators of CD4+ T cell responses in the central nervous system.

1991 • 107 citations

Killing of antigen-reactive B cells by class II- restricted, soluble antigen–specific CD8+ cytolytic T lymphocytes

1988 • 88 citations

Lymphokine Control Of In Vivo Immunoglobulin Isotype Selection

1990 • 87 citations

Suppression of IgE responses by antigen inhalation: studies on the role of genetic and environmental factors.

1987 • 86 citations

Suppression of IgE responses in inbred rats by repeated respiratory tract exposure to antigen: Responder phenotype influences isotype specificity of induced tolerance

1984 • 79 citations

Suppression of IgE responses following inhalation of antigen

1987 • 75 citations

Induction of IgE-isotype specific tolerance by passive antigenic stimulation of the respiratory mucosa.

1983 • 69 citations

Down-regulation of immune responses to inhaled antigen: studies on the mechanism of induced suppression.

1985 • 58 citations

Regulation of T-cell sensitization at epithelial surfaces in the respiratory tract: suppression of IgE responses to inhaled antigens by CD3+ Tcr alpha-/beta- lymphocytes (putative gamma/delta T cells).

1991 • 52 citations

Studies on the surface phenotype and functions of dendritic cells in parenchymal lung tissue of the rat.

1992 • 49 citations

Biochemical and immunological properties of rat recombinant interleukin-2 and interleukin-4.

1992 • 48 citations

Tolerance Induction via Antigen Inhalation: Isotype Specificity, Stability, and Involvement of Suppressor T Cells

1982 • 47 citations

Mechanism of action of interleukin-2 receptor (IL-2R) monoclonal antibody (MAb) therapy: target cell depletion or inhibition of function?

1989 • 41 citations

On the mechanism of human T cell suppression

1989 • 39 citations

Role of dendritic cells in the regulation of class I restricted cytotoxic T lymphocyte responses.

1988 • 31 citations

T cell synergy in the primary MLR: proliferative kinetics, effector cell generation, and IL 2 production.

1984 • 18 citations

A Sensitive Two-Site Enzyme Immunoassay for the Detection of Rat Interferon-γ in Biological Fluids

1990 • 14 citations