Regulation of the interaction between Th1 and Th2 T cell clones to provide help for antibody production in vivo

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

A TH1→TH2 switch is a critical step in the etiology of HIV infection

1993 • 1,403 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells

1988 • 917 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.

1988 • 731 citations

Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones.

1992 • 697 citations

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

1989 • 567 citations

Establishment of Stable, Cell-Mediated Immunity that Makes "Susceptible" Mice Resistant to Leishmania major

1992 • 503 citations

Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.

1993 • 484 citations

Role of T‐Cell Derived Cytokines in the Downregulation of Immune Responses in Parasitic and Retroviral Infection

1992 • 473 citations

T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.

1982 • 445 citations

Role of Cytokines and CD4+ T‐Cell Subsets in the Regulation of Parasite Immunity and Disease

1989 • 405 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.

1991 • 355 citations

Cecil Textbook of Medicine

1992 • 336 citations

IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide.

1988 • 308 citations

Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function

1991 • 286 citations

The Reaction of 2,4-Dinitrobenzenesulfonic Acid with Free Amino Groups of Proteins

1953 • 282 citations

CD4+ T Cells: Specificity and Function

1988 • 281 citations

Regulation of T‐Cell Activation; Differences among T‐Cell Subsets

1989 • 271 citations

Regulation and biological function of helminth-induced cytokine responses

1991 • 260 citations

Induction of IgG3 secretion by interferon gamma: a model for T cell-independent class switching in response to T cell-independent type 2 antigens.

1992 • 258 citations

Regulation of IgG1 and IgE Production by Interleukin 4

1988 • 244 citations

Profiles of lymphokine activities and helper function for IgE in human T cell clones

1988 • 204 citations

Mechanism for transforming growth factor beta and IL-2 enhancement of IgA expression in lipopolysaccharide-stimulated B cell cultures.

1990 • 183 citations

Transforming growth factor beta 1 increases IgA isotype switching at the clonal level.

1990 • 150 citations

Naturally acquired immunity to Plasmodium faldparum

1991 • 148 citations

Transforming growth factor-beta 1 is a costimulator for IgA production.

1990 • 134 citations

ORAL, BUT NOT INTRAVENOUS, ALLOANTIGEN PREVENTS ACCELERATED ALLOGRAFT REJECTION BY SELECTIVE INTRAGRAFT TH2 CELL ACTIVATION

1993 • 124 citations

Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity.

1994 • 112 citations

Selective differentiation of CD4+ T helper cell subsets

1993 • 104 citations

Anti-interferon gamma treatment blocks the ability of glutaraldehyde-polymerized allergens to inhibit specific IgE responses.

1991 • 89 citations

The role of CD40-CD40 ligand interaction in human T cell-B cell collaboration.

1994 • 85 citations

Induction of human IgE synthesis by CD4+ T cell clones. Requirement for interleukin 4 and low molecular weight B cell growth factor.

1989 • 80 citations

Induction of immunoglobulin synthesis by CD4+ T cell clones

1993 • 77 citations

Immunoepidemiology of lymphatic filariasis: the relationship between infection and disease

1991 • 69 citations

IL-4 synthesis by in vivo primed keyhole limpet hemocyanin-specific CD4+ T cells. I. Influence of antigen concentration and antigen-presenting cell type.

1992 • 69 citations

CD4+ T-cell subsets: regulation of differentiation and function

1991 • 67 citations

Generation of B cell memory and affinity maturation. Induction with Th1 and Th2 T cell clones.

1992 • 63 citations

Induction of antigen-specific antibody responses in primed and unprimed B cells. Functional heterogeneity among Th1 and Th2 T cell clones.

1989 • 57 citations

Differential reactivity of V_β9 T cells to minor lymphocyte stimulating antigen in vitro and in vivo

1991 • 55 citations

Hapten-reactive inducer T cells. I. Definition of two classes of hapten-specific inducer cells.

1983 • 49 citations

Induction of antibody synthesis by CD4⁺ T cells: IL 5 is essential for induction of antigen‐specific antibody responses by T_H2 but not T_H1 clones

1990 • 44 citations

The Path of Memory B‐Cell Development

1992 • 42 citations

Effects of route of immunization, adjuvant and unrelated antigens on the humoral immune response in lines of chickens selected for antibody production against sheep erythrocytes

1992 • 41 citations

Murine T-cell clones specific for chicken erythrocyte alloantigens

1986 • 33 citations

Effect of virus strain and antigen dose on immunogenicity and reactogenicity of an inactivated hepatitis A vaccine

1992 • 28 citations

Cytokine-induced differentiation of IgA B cells: studies using an IgA expressing B-cell lymphoma.

1992 • 21 citations

Antigen concentration determines helper T cell subset participation in IgE antibody responses

1992 • 21 citations

Differential regulation of antigen presentation in high‐ and low‐IgE responder mice

1991 • 17 citations

Helminths, immunology and equations

1991 • 11 citations