Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration.

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Leukocyte-endothelial adhesion molecules

1994 • 2,567 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice

1989 • 635 citations

Interleukin-4 is required for the induction of lung Th2 mucosal immunity.

1995 • 364 citations

Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects.

1995 • 342 citations

Detection of eosinophils using an eosinophil peroxidase assay. Its use as an assay for eosinophil differentiation factors

1985 • 303 citations

Studies on the Specificity of the Cellular Infiltrate in Delayed Hypersensitivity Reactions

1963 • 294 citations

Modulation and induction of eosinophil chemotaxis by granulocyte- macrophage colony-stimulating factor and interleukin-3

1991 • 230 citations

Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects

1992 • 226 citations

Inhibition of programmed eosinophil death: a key pathogenic event for eosinophilia?

1995 • 168 citations

Bronchoconstriction and airway hyperresponsiveness after ovalbumin inhalation in sensitized mice

1995 • 105 citations

Modulation of Eosinophil Chemotaxis by Interleukin-5

1992 • 103 citations

Cytokine regulation of eosinophil function

1992 • 101 citations

Allergen-induced increase in airway responsiveness and inflammation in mild asthma

1990 • 96 citations

Leukocyte infiltration in allergic airway inflammation.

1995 • 85 citations

Techniques for drug delivery to the airways, and the assessment of lung function in animal models

1992 • 57 citations

T help requirements for the generation of an in vivo IgE response: a late acting form of T cell help other than IL-4 is required for IgE but not for IgG1 production.

1989 • 52 citations

Distribution of immunocompetent cells in the bronchial wall of clinically healthy subjects showing bronchial hyperresponsiveness.

1993 • 44 citations

Modulation of systemic cytokine levels by implantation of alginate encapsulated cells

1994 • 32 citations

Asthma: Morphologic-Physiologic Interactions

1994 • 31 citations

Semi-preparative purification and validation of monoclonal antibodies for immunotherapy in mice

1994 • 22 citations

Role of Cytokines in Bronchial Hyperresponsiveness

1993 • 20 citations

Interleukin-5 Potentiates Sulfidopeptide Leukotriene Production by Human Eosinophils

1994 • 19 citations