Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells

1988 • 917 citations

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.

1991 • 841 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Mucociliary clearance in the airways.

1996 • 701 citations

Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: Comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness

1991 • 681 citations

Interleukin-5 Expression in the Lung Epithelium of Transgenic Mice Leads to Pulmonary Changes Pathognomonic of Asthma

1997 • 527 citations

Mechanics of Airway Narrowing1–3

2015 • 501 citations

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.

1996 • 437 citations

Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors.

1996 • 436 citations

The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells

1984 • 368 citations

Interleukin-4 is required for the induction of lung Th2 mucosal immunity.

1995 • 364 citations

Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.

1986 • 355 citations

CD4⁺T-Lymphocytes and Interleukin-5 Mediate Antigen-induced Eosinophil Infiltration into the Mouse Trachea

1992 • 353 citations

Increases in Activated T Lymphocytes, Eosinophils, and Cytokine mRNA Expression for Interleukin-5 and Granulocyte/Macrophage Colony-stimulating Factor in Bronchial Biopsies after Allergen Inhalation Challenge in Atopic Asthmatics

1993 • 336 citations

CD4 T-Lymphocyte Activation in Acute Severe Asthma: Relationship to Disease Severity and Atopic Status

1990 • 327 citations

The importance of leukotrienes in airway inflammation in a mouse model of asthma.

1996 • 312 citations

Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue.

1994 • 312 citations

T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma.

1996 • 309 citations

Susceptibility to Leishmania major Infection in Interleukin-4-Deficient Mice

1996 • 292 citations

Generation and in vivo persistence of polarized Th1 and Th2 memory cells

1994 • 283 citations

Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins.

1997 • 275 citations

Mechanisms of Eosinophil Recruitment

1993 • 274 citations

A novel role for murine IL-4 in vivo: induction of MUC5AC gene expression and mucin hypersecretion.

1997 • 263 citations

Elevated Release of Tumor Necrosis Factor-alpha and Interferon-gamma by Bronchoalveolar Leukocytes from Patients with Bronchial Asthma

1993 • 262 citations

Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells.

1987 • 209 citations

Crucial role of 55-kilodalton TNF receptor in TNF-induced adhesion molecule expression and leukocyte organ infiltration.

1996 • 188 citations

Antigen-specific activation of effector macrophages by IFN-gamma producing (TH1) T cell clones. Failure of IL-4-producing (TH2) T cell clones to activate effector function in macrophages.

1989 • 183 citations

The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and I-specificity.

1983 • 181 citations

Differential recruitment of leukocyte populations and alteration of airway hyperreactivity by C-C family chemokines in allergic airway inflammation.

1997 • 177 citations

Distinct functional phenotypes of cloned Ia-restricted helper T cells.

1985 • 171 citations

Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.

1993 • 164 citations

Lymphocyte Activation in Bronchoalveolar Lavage and Peripheral Blood in Atopic Asthma

1992 • 152 citations

CD4 T Lymphocyte Activation in Acute Severe Asthma

1991 • 141 citations

Pathogenesis of airway mucus hypersecretion

1990 • 136 citations

Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype.

1997 • 132 citations

Markers of Mucus Secretion and DNA Levels in Induced Sputum from Asthmatic and from Healthy Subjects

1993 • 104 citations

Human Ciliated Bronchial Epithelial Cells: Expression of the HLA-DR Antigens and of the HLA-DR Alpha Gene, Modulation of the HLA-DR Antigens by Gamma-Interferon and Antigen-presenting Function in the Mixed Leukocyte Reaction

1990 • 85 citations

The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectants.

1986 • 83 citations

Eosinophil cationic protein stimulates and major basic protein inhibits airway mucus secretion

1991 • 79 citations

Expression of the Co-stimulator Molecule B7–1 in Pancreatic β-Cells Accelerates Diabetes in the NOD Mouse

1995 • 67 citations

The relationship between bronchial immunopathology and hyperresponsiveness in asthma

1990 • 54 citations

Evidence that the Thy-1 molecule is the target for T cell mitogenic antibody against brain-associated antigens

1983 • 44 citations

Mucus Hypersecretion and Eosinophils in Bronchoalveolar Lavage Fluid in Adult Patients with Bronchial Asthma

1993 • 39 citations

Theoretic Effects of Mucus Gland Discharge on Airway Resistance in Asthma

1995 • 27 citations

Deleted Work

1955 • 0 citations