T1 and T2 CD4+ cells in human allergic diseases

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

The Inverse Association Between Tuberculin Responses and Atopic Disorder

1997 • 1,305 citations

Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

1994 • 1,025 citations

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.

1995 • 626 citations

Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals.

1993 • 549 citations

Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization.

1996 • 524 citations

Association between atopy and variants of the β subunit of the high–affinity immunoglobulin E receptor

1994 • 406 citations

Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells

1997 • 385 citations

Genetic Susceptibility to Leishmania : IL-12 Responsiveness in T _H 1 Cell Development

1996 • 367 citations

Late Complications of Immune Deviation Therapy in a Nonhuman Primate

1996 • 319 citations

Immunoprophylaxis of allergen–induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization

1996 • 293 citations

Generation and in vivo persistence of polarized Th1 and Th2 memory cells

1994 • 283 citations

Induction of Autoimmune Diabetes by Oral Administration of Autoantigen

1996 • 261 citations

An ovalbumin-IL-12 fusion protein is more effective than ovalbumin plus free recombinant IL-12 in inducing a T helper cell type 1-dominated immune response and inhibiting antigen-specific IgE production.

1997 • 178 citations

IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes.

1995 • 144 citations

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis.

1996 • 144 citations

Regulation of disease susceptibility: Decreased prevalence of IgE-mediated allergic disease in patients with multiple sclerosis

1996 • 89 citations

Differential production of IL-12 in BALB/c and DBA/2 mice controls IL-4 versus IFN-γ synthesis in primed CD4 lymphocytes

1996 • 37 citations