Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1995 • 758 citations

HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation

1989 • 577 citations

Purification of P-TEFb, a Transcription Factor Required for the Transition into Productive Elongation

1995 • 544 citations

The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

1994 • 432 citations

Cdk-activating kinase complex is a component of human transcription factor TFIIH

1995 • 431 citations

Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK

1994 • 426 citations

A kinase–cyclin pair in the RNA polymerase II holoenzyme

1995 • 418 citations

Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II

1992 • 407 citations

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

1992 • 367 citations

Association of Cdk-activating kinase subunits with transcription factor TFIIH

1995 • 366 citations

Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor

1995 • 338 citations

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

1994 • 325 citations

Functional redundancy and structural polymorphism in the large subunit of RNA polymerase II

1987 • 306 citations

The RNA polymerase II holoenzyme and its implications for gene regulation

1995 • 297 citations

Control of formation of two distinct classes of RNA polymerase II elongation complexes.

1992 • 295 citations

HIV-1 Tat protein promotes formation of more-processive elongation complexes.

1991 • 295 citations

Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II.

1987 • 288 citations

Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription.

1986 • 285 citations

Differential Expression of c- myb mRNA in Murine B Lymphomas by a Block to Transcription Elongation

1987 • 279 citations

Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2

1989 • 270 citations

The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal region.

1992 • 266 citations

The C-terminal domain of the largest subunit of RNA polymerase II of Saccharomyces cerevisiae, Drosophila melanogaster, and mammals: a conserved structure with an essential function.

1988 • 246 citations

Transcriptional elongation by RNA polymerase II is stimulated by transactivators

1994 • 243 citations

Inhibition of in Vivo and in Vitro Transcription by Monoclonal Antibodies Prepared against Wheat Germ RNA Polymerase II That React with the Heptapeptide Repeat of Eukaryotic RNA Polymerase II

1989 • 228 citations

Transcription elongation and eukaryotic gene regulation.

1990 • 227 citations

Genetic analysis of the repetitive carboxyl-terminal domain of the largest subunit of mouse RNA polymerase II.

1988 • 212 citations

KIN28 Encodes a C-Terminal Domain Kinase That Controls mRNA Transcription in Saccharomyces cerevisiae but Lacks Cyclin-Dependent Kinase-Activating Kinase (CAK) Activity

1995 • 208 citations

Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain.

1993 • 206 citations

CTD kinase associated with yeast RNA polymerase II initiation factor b

1991 • 199 citations

The C-terminal repeat domain of RNA polymerase II largest subunit is essential in vivo but is not required for accurate transcription initiation in vitro.

1988 • 190 citations

Requirement for TFIIH kinase activity in transcription by RNA polymerase II

1995 • 189 citations

TheKIN28Gene is Required both for RNA Polymerase II Mediated Transcription and Phosphorylation of the Rpb1p CTD

1995 • 185 citations

Hold back of RNA polymerase II at the transcription start site mediates down-regulation of c-myc in vivo.

1992 • 182 citations

The Transcriptional Elongation Inhibitor 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole Inhibits Transcription Factor IIH-associated Protein Kinase

1995 • 178 citations

Postinitiation Transcriptional Control in Drosophila melanogaster

1990 • 177 citations

DNA binding provides a signal for phosphorylation of the RNA polymerase II heptapeptide repeats.

1992 • 133 citations

Phosphorylation of the C-terminal domain of RNA polymerase II

1995 • 133 citations

Novel mechanism and factor for regulation by HIV-1 Tat.

1995 • 128 citations

RNA polymerase: regulation of transcript elongation and termination

1991 • 127 citations

A carboxyl-terminal-domain kinase associated with RNA polymerase II transcription factor delta from rat liver.

1992 • 124 citations

A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II.

1989 • 123 citations

Inhibitors of transcription such as 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and isoquinoline sulfonamide derivatives (H-8 and H-7) promote dephosphorylation of the carboxyl-terminal domain of RNA polymerase II largest subunit.

1994 • 122 citations

The Activity of COOH-terminal Domain Phosphatase Is Regulated by a Docking Site on RNA Polymerase II and by the General Transcription Factors IIF and IIB

1995 • 121 citations

Regulation of transcriptional elongation by RNA polymerase II

1995 • 111 citations

Fractionation of transcription factors for RNA polymerase II from Drosophila Kc cell nuclear extracts.

1987 • 103 citations

c-fos gene transcription in murine macrophages is modulated by a calcium-dependent block to elongation in intron 1.

1991 • 102 citations

The Role of Multisite Phosphorylation in the Regulation of RNA Polymerase II Activity

1994 • 100 citations

Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation.

1993 • 89 citations

The Major Late Promoter of Adenovirus-2 Is Accurately Transcribed by RNA Polymerases IIO, IIA, and IIB

1989 • 83 citations

Adenosine Deaminase Gene Expression

1989 • 83 citations

RNA polymerases IIA and IIO have distinct roles during transcription from the TATA-less murine dihydrofolate reductase promoter.

1993 • 81 citations

Partial purification and characterization of two distinct protein kinases that differentially phosphorylate the carboxyl-terminal domain of RNA polymerase subunit IIa.

1993 • 75 citations

Short Transcripts of the Ternary Complex Provide Insight into RNA Polymerase II Elongational Pausing

1995 • 73 citations

Interplay of positive and negative effectors in function of the C-terminal repeat domain of RNA polymerase II.

1994 • 64 citations

Stability of Drosophila RNA Polymerase II Elongation Complexes In Vitro

1992 • 62 citations

Purification of an RNA Polymerase II Transcript Release Factor from Drosophila

1996 • 51 citations

Regulation of eukaryotic gene expression by transcriptional attenuation.

1993 • 45 citations

Elements modulating the block of transcription elongation at the adenovirus 2 attenuation site

1989 • 45 citations

Phosphorylation State of the RNA Polymerase II C‐Terminal Domain (CTD) in Heat‐Shocked Cells

1995 • 42 citations

Sequence requirements for transcriptional arrest in exon 1 of the human adenosine deaminase gene.

1991 • 38 citations

Phosphorylation dependence of the initiation of productive transcription of balbiani ring 2 genes in living cells

1996 • 28 citations

Distinct Properties of c-myc Transcriptional Elongation Are Revealed in Xenopus Oocytes and Mammalian Cells and by Template Titration, 5,6-Dichloro-1-β-D-Ribofuranosylbenzimidazole (DRB), and Promoter Mutagenesis

1993 • 27 citations

Protein kinases from Aspergillus nidulans that phosphorylate the carboxyl-terminal domain of the largest subunit of RNA polymerase II.

1992 • 26 citations

Purification of the Drosophila RNA polymerase II general transcription factors.

1996 • 26 citations

Premature Termination of Transcription Can Be Induced on an Injected α-Tubulin Gene in Xenopus Oocytes

1990 • 23 citations

The Block to Transcription Elongation at the Minute Virus of Mice Attenuator Is Regulated by Cellular Elongation Factors

1991 • 19 citations

Functional studies of the carboxy-terminal repeat domain of Drosophila RNA polymerase II in vivo.

1995 • 14 citations

Premature termination of tubulin gene transcription in Xenopus oocytes is due to promoter-dependent disruption of elongation.

1993 • 12 citations

A 21-base pair DNA fragment directs transcription attenuation within the simian virus 40 late leader

1991 • 7 citations