Inhibitors of transcription such as 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and isoquinoline sulfonamide derivatives (H-8 and H-7) promote dephosphorylation of the carboxyl-terminal domain of RNA polymerase II largest subunit.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

RNA POLYMERASE II

1991 • 729 citations

Heat Shock Response

1991 • 576 citations

Actinomycin and DNA transcription.

1985 • 535 citations

Inhibition of RNA synthesis by actinomycin D: Characteristic dose‐response of different RNA species

1970 • 531 citations

Structure and expression of the human gene encoding major heat shock protein HSP70.

1985 • 461 citations

Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses.

1992 • 417 citations

Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II

1992 • 407 citations

RNA polymerase II is a glycoprotein. Modification of the COOH-terminal domain by O-GlcNAc

1993 • 388 citations

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

1992 • 367 citations

The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences.

1985 • 355 citations

RNA Polymerase B (II) And General Transcription Factors

1990 • 355 citations

Tails of RNA polymerase II

1990 • 320 citations

Control of formation of two distinct classes of RNA polymerase II elongation complexes.

1992 • 295 citations

Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription.

1986 • 285 citations

Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2

1989 • 270 citations

Powerful and versatile enhancer-promoter unit for mammalian expression vectors

1986 • 263 citations

The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIa

1989 • 236 citations

Inhibition of in Vivo and in Vitro Transcription by Monoclonal Antibodies Prepared against Wheat Germ RNA Polymerase II That React with the Heptapeptide Repeat of Eukaryotic RNA Polymerase II

1989 • 228 citations

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro

1989 • 225 citations

Specific interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding protein

1992 • 219 citations

CTD kinase associated with yeast RNA polymerase II initiation factor b

1991 • 199 citations

Firefly luciferase luminescence assays using scintillation counters for quantitation in transfected mammalian cells

1988 • 199 citations

Phosphorylation of RNA polymerase IIA occurs subsequent to interaction with the promoter and before the initiation of transcription.

1990 • 178 citations

A functional interaction between the C-terminal domain of RNA polymerase II and the negative regulator SIN1

1991 • 176 citations

Phosphorylation of C-terminal domain of RNA polymerase II is not required in basal transcription

1993 • 176 citations

CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae.

1991 • 170 citations

A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID

1992 • 170 citations

RNA polymerase II C-terminal repeat influences response to transcriptional enhancer signals

1990 • 163 citations

Phosphorylation of eukaryotic DNA-dependent RNA polymerase. Identification of calf thymus RNA polymerase subunits phosphorylated by two purified protein kinases, correlation with in vivo sites of phosphorylation in HeLa cell RNA polymerase II.

1981 • 159 citations

Advances in RNA polymerase II transcription

1992 • 144 citations

DRB-induced premature termination of late adenovirus transcription

1978 • 136 citations

[27] Properties and use of H-series compounds as protein kinase inhibitors

1991 • 131 citations

Action of dichlorobenzimidazole riboside on RNA synthesis in L-929 and HeLa cells.

1976 • 125 citations

A carboxyl-terminal-domain kinase associated with RNA polymerase II transcription factor delta from rat liver.

1992 • 124 citations

Mutations in RNA polymerase II enhance or suppress mutations in GAL4.

1989 • 123 citations

A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II.

1989 • 123 citations

Mechanism of action of DRB

1983 • 117 citations

Inhibitory effect of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on a protein kinase.

1984 • 111 citations

Monoclonal antibody directed against RNA polymerase II of Drosophila melanogaster

1980 • 105 citations

The heptad repeat in the largest subunit of RNA polymerase II binds by intercalating into DNA

1990 • 103 citations

Immunochemical analysis of mammalian RNA polymerase II subspecies. Stability and relative in vivo concentration.

1986 • 89 citations

RNA polymerase II carboxy-terminal domain contributes to the response to multiple acidic activators in vitro.

1991 • 85 citations

Phosphorylation causes a conformational change in the carboxyl-terminal domain of the mouse RNA polymerase II largest subunit

1991 • 85 citations

Partial purification and characterization of two distinct protein kinases that differentially phosphorylate the carboxyl-terminal domain of RNA polymerase subunit IIa.

1993 • 75 citations

Multifunctional RNA polymerase II initiation factor delta from rat liver. Relationship between carboxyl-terminal domain kinase, ATPase, and DNA helicase activities

1993 • 68 citations

Phosphorylation of the RNA polymerase II largest subunit during heat shock and inhibition of transcription in hela cells

1994 • 57 citations

Purification of RNA polymerase IIO from calf thymus.

1988 • 50 citations

RNA polymerase II transcription cycles

1993 • 47 citations

[24] Purification of protein kinases that phosphorylate the repetitive carboxyl-terminal domain of eukaryotic RNA polymerase II

1991 • 45 citations

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits a HeLa protein kinase that phosphorylates an RNA polymerase II-derived peptide

1989 • 39 citations

Polymerase processivity and termination on Drosophila heat shock genes.

1993 • 32 citations

Heat‐shock and related stress enhance RNA polymerase II C‐terminal‐domain kinase activity in HeLa cell extracts

1990 • 32 citations

Distinct Properties of c-myc Transcriptional Elongation Are Revealed in Xenopus Oocytes and Mammalian Cells and by Template Titration, 5,6-Dichloro-1-β-D-Ribofuranosylbenzimidazole (DRB), and Promoter Mutagenesis

1993 • 27 citations

Protein kinases from Aspergillus nidulans that phosphorylate the carboxyl-terminal domain of the largest subunit of RNA polymerase II.

1992 • 26 citations