Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

1962 • 2,192 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights

1990 • 992 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

1990 • 714 citations

The TGF-β family and its composite receptors

1994 • 539 citations

Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis

1997 • 466 citations

Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice

1990 • 447 citations

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

1990 • 444 citations

Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.

1994 • 432 citations

Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation

1995 • 415 citations

Reversible Inhibition of Mammary Gland Growth by Transforming Growth Factor-β

1987 • 408 citations

Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression [published erratum appears in J Cell Biol 1996 Feb;132(4):following 752]

1994 • 405 citations

Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction.

1994 • 395 citations

Inactivation of the Type II Receptor Reveals Two Receptor Pathways for the Diverse TGF-β Activities

1993 • 388 citations

Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts.

1986 • 339 citations

Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells

1994 • 325 citations

In situ hybridization analysis of TGFβ3 RNA expression during mouse development: comparative studies with TGFβ1 and β2

1990 • 325 citations

Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation

1995 • 285 citations

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

1993 • 260 citations

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

1997 • 257 citations

Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II

1991 • 252 citations

Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors

1996 • 250 citations

TGF‐β Receptors and TGF‐β Binding Proteoglycans: Recent Progress in Identifying Their Functional Properties

1990 • 233 citations

Regulated expression and growth inhibitory effects of transforming growth factor-β isoforms in mouse mammary gland development

1991 • 228 citations

Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

1993 • 224 citations

Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development.

1995 • 194 citations

Ectopic TGFβ1 Expression in the Secretory Mammary Epithelium Induces Early Senescence of the Epithelial Stem Cell Population

1995 • 182 citations

TGF-β1-induced inhibition of mouse mammary ductal growth: Developmental specificity and characterization

1989 • 174 citations

Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis.

1996 • 161 citations

Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction?

1994 • 145 citations

Inhibition of Capillary Morphogenesis and Associated Apoptosis by Dominant Negative Mutant Transforming Growth Factor-β Receptors

1995 • 142 citations

A dominant-negative receptor for type beta transforming growth factors created by deletion of the kinase domain

1993 • 131 citations

Epithelium-dependent extracellular matrix synthesis in transforming growth factor-beta 1-growth-inhibited mouse mammary gland.

1990 • 124 citations

Regulation of mammary morphogenesis: Evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-β1

1992 • 114 citations

Transgenic mice carrying the mouse mammary tumor virus ras fusion gene: distinct effects in various tissues.

1989 • 99 citations

TGF beta suppresses casein synthesis in mouse mammary explants and may play a role in controlling milk levels during pregnancy.

1993 • 90 citations

Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-alpha in mouse mammary epithelial cells: studies in culture and in transgenic mice.

1995 • 88 citations

Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-β receptor

1994 • 86 citations

Negative regulation in correct tissue-specific expression of mouse mammary tumor virus in transgenic mice.

1990 • 60 citations

Inactive Type II and Type I Receptors for TGFβ Are Dominant Inhibitors of TGFβ-dependent Transcription

1995 • 54 citations

Transforming Growth Factor-β Inhibits Lactogenic Hormone Induction of β-Casein Expression in HC11 Mouse Mammary Epithelial Cells

1990 • 46 citations

Analysis of Hornozygous TGFβ1 Null Mouse Embryos Demonstrates Defects in Yolk Sac. Vasculogenesis and Hematopoiesis

1995 • 44 citations

Stromal-epithelial interactions in normal and neoplastic mammary gland

1991 • 33 citations

Transforming growth factor-β1 inhibits casein secretion from differentiating mammary-gland explants but not from lactating mammary cells

1994 • 25 citations

Involvement of autocrine mechanism of transforming growth factor-β in the functional differentiation of pregnant mouse mammary gland

1994 • 12 citations