Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

1987 • 1,287 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights

1990 • 992 citations

Transforming growth factor-beta: recent progress and new challenges.

1992 • 781 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

1990 • 714 citations

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.

1992 • 675 citations

Receptors for the TGF-β family

1992 • 638 citations

Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells.

1986 • 542 citations

The cell biology of transforming growth factor β

1990 • 537 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

The murine transforming growth factor-beta precursor.

1986 • 492 citations

Reversible Inhibition of Mammary Gland Growth by Transforming Growth Factor-β

1987 • 408 citations

Transforming growth factor-beta 1: histochemical localization with antibodies to different epitopes.

1989 • 378 citations

Transgenic Mice as Probes into Complex Systems

1989 • 368 citations

Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action

1988 • 347 citations

Normal embryo fibroblasts release transforming growth factors in a latent form

1984 • 336 citations

Recombinant latent transforming growth factor beta 1 has a longer plasma half-life in rats than active transforming growth factor beta 1, and a different tissue distribution.

1990 • 311 citations

A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland

1988 • 233 citations

Transforming growth factor-beta. Multiple actions and potential clinical applications

1989 • 229 citations

Regulated expression and growth inhibitory effects of transforming growth factor-β isoforms in mouse mammary gland development

1991 • 228 citations

Site-directed Mutagenesis of Cysteine Residues in the Pro Region of the Transforming Growth Factor β1 Precursor

1989 • 220 citations

The mammary gland

1991 • 216 citations

Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity.

1992 • 205 citations

TGF-β1-induced inhibition of mouse mammary ductal growth: Developmental specificity and characterization

1989 • 174 citations

Effect of transforming growth factor beta on cell death of cultured rat hepatocytes.

1991 • 166 citations

Sandwich Enzyme-Linked Immunosorbent Assays (Selisas) Quantitate and Distinguish Two Forms of Transforming Growth Factor-Beta (TGF-β1 and TGF-β2) in Complex Biological Fluids

1989 • 127 citations

Autocrine induction of tumor protease production and invasion by a metallothionein-regulated TGF-beta 1 (Ser223, 225).

1992 • 121 citations

Bi‐functional action of transforming growth factor‐β on DNA synthesis in early passage human fetal fibroblasts

1986 • 121 citations

Regulation of the synthesis and activity of urokinase plasminogen activator in A549 human lung carcinoma cells by transforming growth factor-beta

1988 • 118 citations

Regulation of mammary morphogenesis: Evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-β1

1992 • 114 citations

Differential keratin gene expression in developing, differentiating, preneoplastic, and neoplastic mouse mammary epithelium.

1990 • 106 citations

cDNA cloning of porcine transforming growth factor-beta 1 mRNAs. Evidence for alternate splicing and polyadenylation.

1988 • 95 citations

TGF beta suppresses casein synthesis in mouse mammary explants and may play a role in controlling milk levels during pregnancy.

1993 • 90 citations

Over-expression of an endogenous milk protein gene in transgenic mice is associated with impaired mammary alveolar development and a milchlos phenotype

1991 • 71 citations

Production of the mouse whey acidic protein in transgenic pigs during lactation

1991 • 54 citations

Inactivation of a sperm motility gene by insertion of an epidermal growth factor receptor transgene whose product is overexpressed and compartmentalized during spermatogenesis.

1991 • 46 citations

Transforming Growth Factor-β Inhibits Lactogenic Hormone Induction of β-Casein Expression in HC11 Mouse Mammary Epithelial Cells

1990 • 46 citations

Long-term in vivo expression of genes introduced by retrovirus-mediated transfer into mammary epithelial cells

1991 • 44 citations

Transgenic animals in biomedical research

1991 • 31 citations