Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury

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1994 • 4,654 citations

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

2003 • 2,755 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

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Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses

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Sir Isaac Newton, sepsis, SIRS, and CARS

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Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

1983 • 861 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

An innate sense of danger

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Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

Control of Regulatory T Cell Lineage Commitment and Maintenance

2009 • 557 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

2012 • 462 citations

SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS), MULTIPLE ORGAN DYSFUNCTION SYNDROME (MODS), MULTIPLE ORGAN FAILURE (MOF)

1998 • 455 citations

CD4+ Tregs and immune control

2004 • 417 citations

Splenic Atrophy in Experimental Stroke Is Accompanied by Increased Regulatory T Cells and Circulating Macrophages

2006 • 382 citations

The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells

1984 • 368 citations

Cutting Edge: Anti-CD25 Monoclonal Antibody Injection Results in the Functional Inactivation, Not Depletion, of CD4+CD25+ T Regulatory Cells

2006 • 333 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

Regulatory T Cells Suppress Innate Immunity in Kidney Ischemia-Reperfusion Injury

2009 • 326 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

Regulatory T Cells Ameliorate Angiotensin II–Induced Cardiac Damage

2009 • 310 citations

Macrophages and post-burn immune dysfunction

2003 • 303 citations

Foxp3: a critical regulator of the development and function of regulatory T cells

2004 • 296 citations

Injury Primes the Innate Immune System for Enhanced Toll-Like Receptor Reactivity

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The inflammatory response to surgery and trauma

2006 • 200 citations

CD4+CD25+ Regulatory T Cells Control Innate Immune Reactivity after Injury

2005 • 185 citations

Early Risk Factors for Postinjury Multiple Organ Failure

1996 • 154 citations

Increased CD4+ CD25+ T Regulatory Cell Activity in Trauma Patients Depresses Protective Th1 Immunity

2006 • 127 citations

Dominance of T-Helper 2–Type Cytokines After Severe Injury

1996 • 123 citations

Enhanced Regulatory T Cell Activity Is an Element of the Host Response to Injury

2006 • 104 citations

MOF, MODS, AND SIRS

2006 • 98 citations

Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4

2006 • 96 citations

Anti-interleukin-10 antibody restores burn-induced defects in T-cell function

1997 • 94 citations

Postinjury multiple organ failure: role of extrathoracic injury and sepsis in adult respiratory distress syndrome.

1993 • 93 citations

Molecular orchestration of differentiation and function of regulatory T cells

2009 • 77 citations

Early Trauma Polymorphonuclear Neutrophil Responses to Chemokines Are Associated with Development of Sepsis, Pneumonia, and Organ Failure

2001 • 77 citations

Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells

2007 • 75 citations

SEVERE INJURY TRIGGERS ANTIGEN-SPECIFIC T-HELPER CELL DYSFUNCTION

1999 • 73 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3[+]CD25[+]CD4[+] regulatory T cells

2006 • 70 citations

Burn Injury Promotes Antigen-Driven Th2-Type Responses In Vivo

2003 • 69 citations

Cutting Edge: Regulatory T Cells Do Not Require Stimulation through Their TCR to Suppress

2009 • 69 citations

Partial role of TLR4 as a receptor responding to damage-associated molecular pattern

2009 • 58 citations

γδ T Cells Promote Anterior Chamber-Associated Immune Deviation and Immune Privilege through Their Production of IL-10

2006 • 55 citations

Expression of Dual TCR on DO11.10 T Cells Allows for Ovalbumin-Induced Oral Tolerance to Prevent T Cell-Mediated Colitis Directed against Unrelated Enteric Bacterial Antigens

2004 • 55 citations

Postburn Constitutional Changes in T-cell Reactivity Occur in CD8 sup + Rather than in CD4 sup + Cells

1997 • 55 citations

Early down-regulation of the pro-inflammatory potential of monocytes is correlated to organ dysfunction in patients after severe multiple injury: a cohort study

2009 • 54 citations

Humoral and cellular immunity following severe head injury: review and current investigations^‡

1991 • 46 citations

Controlled Autoimmunity in CNS Maintenance and Repair: Naturally Occurring CD4+CD25+ Regulatory T-Cells at the Crossroads of Health and Disease

2005 • 44 citations

BURN INJURY INDUCES AN EARLY ACTIVATION RESPONSE BY LYMPH NODE CD4+ T CELLS

2006 • 39 citations

Use of Intracellular Cytokine Staining and Bacterial Superantigen to Document Suppression of the Adaptive Immune System in Injured Patients

2003 • 35 citations

Burn injury primes naive CD4+ T cells for an augmented T-helper 1 response

1998 • 33 citations

Th1- and Th2-Type Cytokines in Plasma After Major Trauma

2008 • 32 citations

Liver injury is associated with enhanced regulatory T‐cell activity in patients with chronic hepatitis B

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Regulatory T Cells Control VEGF-Dependent Skin Inflammation

2008 • 22 citations

Thermal Injury-Induced Enhancement of Oxidative Metabolism by Mononuclear Phagocytes

1999 • 13 citations

The influence of major trauma on the regulatory levels of interleukin-1 (IL-1) and IL-2 in human mononuclear leukocytes.

1993 • 7 citations