Increased CD4+ CD25+ T Regulatory Cell Activity in Trauma Patients Depresses Protective Th1 Immunity

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Multiple Organ Failure Pathophysiology and Potential Future Therapy

1992 • 1,398 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Sepsis: A New Hypothesis for Pathogenesis of the Disease Process

1997 • 1,014 citations

Major Injury Leads to Predominance of the T Helper-2 Lymphocyte Phenotype and Diminished Interleukin-12 Production Associated with Decreased Resistance to Infection

1995 • 503 citations

Postinjury Multiple Organ Failure

1996 • 490 citations

Human CD4+CD25+ regulatory T cells

2004 • 389 citations

CD4+CD25+ Regulatory T Cells Control the Severity of Viral Immunoinflammatory Lesions

2004 • 357 citations

Update on the Mechanisms of Immune Suppression of Injury and Immune Modulation

1996 • 297 citations

Foxp3: a critical regulator of the development and function of regulatory T cells

2004 • 296 citations

Depression of Cellular Immunity After Major Injury

1986 • 252 citations

The Immunologic Response To Injury

2001 • 233 citations

Inadequate Interleukin 2 Production

1984 • 211 citations

CD4+CD25+ Regulatory T Cells Control Innate Immune Reactivity after Injury

2005 • 185 citations

Radiologic Evaluation in Lung Cancer

1997 • 183 citations

Dominance of T-Helper 2–Type Cytokines After Severe Injury

1996 • 123 citations

Enhanced Regulatory T Cell Activity Is an Element of the Host Response to Injury

2006 • 104 citations

Cell-Mediated Immunity after Thermal Injury

1973 • 99 citations

Induction of Global Anergy Rather Than Inhibitory Th2 Lymphokines Mediates Posttrauma T Cell Immunodepression

2000 • 96 citations

Regulatory cells and human cancer

2005 • 82 citations

CD4⁺CD25⁺‐Regulatory T Cells from Mouse to Man

2005 • 82 citations

Regulation of tumour immunity by CD25⁺ T cells

2002 • 80 citations

SEVERE INJURY TRIGGERS ANTIGEN-SPECIFIC T-HELPER CELL DYSFUNCTION

1999 • 73 citations

Burn Injury Promotes Antigen-Driven Th2-Type Responses In Vivo

2003 • 69 citations

Use of Intracellular Cytokine Staining and Bacterial Superantigen to Document Suppression of the Adaptive Immune System in Injured Patients

2003 • 35 citations

Lymphocyte activation after non-thermal trauma

2000 • 29 citations

Self and non-self discrimination is needed for the existence rather than deletion of autoimmunity: the role of regulatory T cells in protective autoimmunity

2004 • 14 citations

Injury-Induced Immune Dysfunction: Is the Lymphocyte Irrelevant?

2002 • 8 citations