Controlled Autoimmunity in CNS Maintenance and Repair: Naturally Occurring CD4+CD25+ Regulatory T-Cells at the Crossroads of Health and Disease

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

1999 • 881 citations

T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions

2004 • 466 citations

Apoptosis After Traumatic Brain Injury

2000 • 414 citations

Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?

1997 • 403 citations

The cognitive paradigm and the immunological homunculus

1992 • 375 citations

Activation of microglia by aggregated β-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-γ and IL-4 render them protective

2005 • 355 citations

Protective Autoimmunity Is a Physiological Response to CNS Trauma

2001 • 349 citations

Leukocyte traffic in the central nervous system: the participants and their roles

1999 • 348 citations

T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: Possible therapy for optic neuropathies

2000 • 312 citations

Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease

2004 • 310 citations

Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: Implications for glaucoma

2001 • 293 citations

The fate of allogeneic and xenogeneic neuronal tissue transplanted into the third ventricle of rodents

1986 • 284 citations

Neuroprotective autoimmunity: Naturally occurring CD4 ⁺ CD25 ⁺ regulatory T cells suppress the ability to withstand injury to the central nervous system

2002 • 261 citations

Concept of autoimmunity following spinal cord injury: Possible roles for T lymphocytes in the traumatized central nervous system

1996 • 248 citations

Degeneration of Spared Axons Following Partial White Matter Lesion: Implications for Optic Nerve Neuropathies

1998 • 214 citations

The cognitive principle challenges clonal selection

1992 • 212 citations

Protective autoimmunity: interferon‐γ enables microglia to remove glutamate without evoking inflammatory mediators

2005 • 207 citations

Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease

2001 • 205 citations

Therapeutic vaccine for acute and chronic motor neuron diseases: Implications for amyotrophic lateral sclerosis

2003 • 201 citations

Dopamine, through the Extracellular Signal-Regulated Kinase Pathway, Downregulates CD4⁺CD25⁺Regulatory T-Cell Activity: Implications for Neurodegeneration

2004 • 184 citations

Protective autoimmunity: regulation and prospects for vaccination after brain and spinal cord injuries

2001 • 164 citations

Dual effect of CD4⁺CD25⁺regulatory T cells in neurodegeneration: A dialogue with microglia

2004 • 159 citations

Differential T cell response in central and peripheral nerve injury: connection with immune privilege

1999 • 157 citations

Vaccination for Neuroprotection in the Mouse Optic Nerve: Implications for Optic Neuropathies

2001 • 156 citations

Protective autoimmunity against the enemy within: fighting glutamate toxicity

2003 • 130 citations

Morphological aspects of spinal cord autoimmune neuroprotection: colocalization of T cells with B7–2 (CD86) and prevention of cyst formation

2001 • 111 citations

Interpreting MHC class I expression and class I/class II reciprocity in the CNS: Reconciling divergent findings

1995 • 105 citations

Inflammation in the nervous system. Basic mechanisms and immunological concepts.

1991 • 100 citations

Dual action of glatiramer acetate (Cop-1) in the treatment of CNS autoimmune and neurodegenerative disorders

2002 • 87 citations

Antigenic Specificity of Immunoprotective Therapeutic Vaccination for Glaucoma

2003 • 83 citations

The Tissue-Specific Self-Pathogen Is the Protective Self-Antigen: The Case of Uveitis

2002 • 69 citations

The immune system and the nervous system

1983 • 66 citations

The discovery of immunologic tolerance

1997 • 39 citations

Transplantation in the Central Nervous System

1986 • 29 citations

Estimation of the Frequency of Self-reactive T cells in Health and Inflammatory Diseases by Limiting Dilution Analysis and Single Cell Cloning

1996 • 28 citations

Specific vaccines against autoimmune diseases

1999 • 24 citations

Unique Aspects of Central Nervous System Immunology

1978 • 22 citations

The Concept of Specific Immune Treatment Against Autoimmune Diseases

1999 • 18 citations

Self and non-self discrimination is needed for the existence rather than deletion of autoimmunity: the role of regulatory T cells in protective autoimmunity

2004 • 14 citations

Structural Components Responsible for Peptide Antigenicity

2000 • 12 citations

LYMPHATIC DRAINAGE OF THE BRAIN

1975 • 7 citations