Enhanced Regulatory T Cell Activity Is an Element of the Host Response to Injury

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Molecular identification of a danger signal that alerts the immune system to dying cells

2003 • 1,649 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

2004 • 1,123 citations

Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

2003 • 976 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

2003 • 748 citations

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

2004 • 643 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

2003 • 582 citations

Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses

2002 • 495 citations

Postinjury Multiple Organ Failure

1996 • 490 citations

SEPSIS SYNDROMES: UNDERSTANDING THE ROLE OF INNATE AND ACQUIRED IMMUNITY

2001 • 484 citations

CD4 ⁺ CD25 ⁺ T regulatory cells control anti-islet CD8 ⁺ T cells through TGF-β–TGF-β receptor interactions in type 1 diabetes

2003 • 439 citations

TGF-β regulatesin vivoexpansion of Foxp3-expressing CD4⁺CD25⁺regulatory T cells responsible for protection against diabetes

2004 • 425 citations

The Role of IL-10 and TGF-β in the Differentiation and Effector Function of T Regulatory Cells

2002 • 408 citations

Toll-Dependent Control Mechanisms of CD4 T Cell Activation

2004 • 392 citations

IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells

2004 • 354 citations

Suppressor Cells and Immunoregulation

1984 • 337 citations

THE EFFECTS OF INJURY ON THE ADAPTIVE IMMUNE RESPONSE

1999 • 306 citations

Update on the Mechanisms of Immune Suppression of Injury and Immune Modulation

1996 • 297 citations

Clinical review: immunodepression in the surgical patient and increased susceptibility to infection.

2002 • 258 citations

CD4+ CD25+ CD62+ T-Regulatory Cell Subset Has Optimal Suppressive and Proliferative Potential

2003 • 194 citations

CD4+CD25+ Regulatory T Cells Control Innate Immune Reactivity after Injury

2005 • 185 citations

A Comparative Study between T Regulatory Type 1 and CD4+CD25+ T Cells in the Control of Inflammation

2003 • 153 citations

Control of Immune Pathology by Regulatory T Cells

2003 • 136 citations

Temporal correlation of impaired immune response after thermal injury with susceptibility to infection in a murine model.

1988 • 135 citations

Injury Induces Deficient Interleukin-12 Production, But Interleukin-12 Therapy After Injury Restores Resistance to Infection

2000 • 128 citations

Dominance of T-Helper 2–Type Cytokines After Severe Injury

1996 • 123 citations

Interleukin-12 treatment restores normal resistance to bacterial challenge after burn injury

1996 • 107 citations

Predicting Fatal Sepsis in Burn Patients

1979 • 104 citations

Participation of Prostaglandin E in Immunosuppression following Thermal Injury

1984 • 103 citations

Interaction Between the Innate and Adaptive Immune Systems is Required to Survive Sepsis and Control Inflammation After Injury

2003 • 97 citations

PROLONGED SURVIVAL OF HUMAN SKIN ALLOGRAFTS FOLLOWING THERMAL INJURY

1978 • 91 citations

Protective Effects of Early Interleukin 10 Antagonism on Injury-Induced Immune Dysfunction

1999 • 86 citations

Growth Hormone and Cortisol Secretion in Patients With Burn Injury

1992 • 81 citations

SEVERE INJURY TRIGGERS ANTIGEN-SPECIFIC T-HELPER CELL DYSFUNCTION

1999 • 73 citations

BLOCKING PROSTAGLANDIN E2 AFTER TRAUMA ATTENUATES PRO-INFLAMMATORY CYTOKINES AND IMPROVES SURVIVAL

2000 • 69 citations

Burn Injury Promotes Antigen-Driven Th2-Type Responses In Vivo

2003 • 69 citations

Suppressor T cells: some answers but more questions

1992 • 53 citations

SEPSIS AND SEPTIC COMPLICATIONS IN THE SURGICAL PATIENT

1996 • 50 citations

Type 1 T Regulatory Cells and Their Relationship with CD4 ⁺ CD25 ⁺ T Regulatory Cells

2003 • 49 citations

An Increase in the Susceptibility of Burned Patients to Infectious Complications Due to Impaired Production of Macrophage Inflammatory Protein 1α

2002 • 48 citations

Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury

2002 • 46 citations

A burn induced Ly-2 suppressor T cell lowers resistance to bacterial infection

1985 • 44 citations

Immunoregulation after thermal injury: sequential appearance of I-J+, Ly-1 T suppressor inducer cells and Ly-2 T suppressor effector cells following thermal trauma in mice.

1984 • 44 citations

SEPSIS AND SEPTIC COMPLICATIONS IN THE SURGICAL PATIENT

1996 • 37 citations

Polyclonal Immunoglobulin Production in Burned Patients??? Kinetics and Correlations with T-cell Activity

1986 • 22 citations

Stress and Immunity After Traumatic Injury: The Mind—Body Link

1996 • 17 citations

Kinetics of lymphoproliferative responses following scald injury in a rat burn model

1986 • 7 citations