Th1- and Th2-Type Cytokines in Plasma After Major Trauma

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

Therapeutic intervention scoring system

1974 • 1,203 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

The Abbreviated Injury Scale and Injury Severity Score

1985 • 614 citations

Major Injury Leads to Predominance of the T Helper-2 Lymphocyte Phenotype and Diminished Interleukin-12 Production Associated with Decreased Resistance to Infection

1995 • 503 citations

Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the trauma

1996 • 390 citations

Th1-Th2: Reliable paradigm or dangerous dogma?

1997 • 312 citations

Update on the Mechanisms of Immune Suppression of Injury and Immune Modulation

1996 • 297 citations

Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions

1999 • 224 citations

Relationship of Interleukin-10 Plasma Levels to Severity of Injury and Clinical Outcome in Injured Patients

1997 • 219 citations

Trauma: the role of the innate immune system.

2006 • 208 citations

Downregulation of T helper type 1 immune response and altered pro-inflammatory and anti-inflammatory T cell cytokine balance following conventional but not laparoscopic surgery11This work was supported by DFG grants Si 208/5-1 and Si 208/5-4 to the clinical research group, “Immunosuppression und Postoperative Sepsis.”

1999 • 179 citations

Polymicrobial Sepsis but Not Low-Dose Endotoxin Infusion Causes Decreased Splenocyte IL-2/IFN-γ Release While Increasing IL-4/IL-10 Production

1994 • 156 citations

T-cell reactivity and its predictive role in immunosuppression after burns

1999 • 151 citations

Dominance of T-Helper 2–Type Cytokines After Severe Injury

1996 • 123 citations

LYMPHOCYTE SUBSET RESPONSES TO TRAUMA AND SEPSIS

1993 • 118 citations

Prolonged Immunodepression after Trauma and Hemorrhagic Shock

1998 • 106 citations

The “T” in Trauma: the Helper T-cell Response and the Role of Immunomodulation in Trauma and Burn Patients

2007 • 99 citations

Induction of Global Anergy Rather Than Inhibitory Th2 Lymphokines Mediates Posttrauma T Cell Immunodepression

2000 • 96 citations

Anti-interleukin-10 antibody restores burn-induced defects in T-cell function

1997 • 94 citations

Therapeutic intervention scoring system

1974 • 89 citations

THE IMPACT OF FEMUR FRACTURE WITH ASSOCIATED SOFT TISSUE INJURY ON IMMUNE FUNCTION AND INTESTINAL PERMEABILITY

1996 • 77 citations

Immune-inflammatory mechanisms in IFNγ-mediated anti-tumor activity

2000 • 75 citations

Altered Gene Transcription After Burn Injury Results in Depressed T-Lymphocyte Activation

1994 • 70 citations

Both T-Helper-1- and T-Helper-2-Type Lymphokines Are Depressed in Posttrauma Anergy

1998 • 69 citations

Measurement of intracellular cytokines

1996 • 69 citations

INADEQUATE INTERLEUKIN-2 SYNTHESIS AND INTERLEUKIN-2 MESSENGER EXPRESSION FOLLOWING THERMAL AND MECHANICAL TRAUMA IN HUMANS IS CAUSED BY DEFECTIVE TRANSMEMBRANE SIGNALLING

1993 • 66 citations

Reduced Th1, but Not Th2, Cytokine Production by Lymphocytes after In Vivo Exposure of Healthy Subjects to Endotoxin

2000 • 64 citations

Interleukin-11

1997 • 61 citations

Postburn Constitutional Changes in T-cell Reactivity Occur in CD8 sup + Rather than in CD4 sup + Cells

1997 • 55 citations

Effects ofin vivo endotoxin infusions onin vitro cellular immune responses in humans

1992 • 55 citations

IL-18 promoter polymorphisms correlate with the development of post-injury sepsis

2003 • 53 citations

Major Surgery Suppresses Maximal Production of Helper T-Cell Type 1 Cytokines Without Potentiating the Release of Helper T-Cell Type 2 Cytokines

1999 • 43 citations

Therapeutic immunomodulatory approaches for the control of systemic inflammatory response syndrome and the prevention of sepsis.

1998 • 36 citations

THE 1996 MOYER AWARD

1996 • 35 citations

Human memory T cell differentiation into Th2-like effector cells is dependent on IL-4 and CD28 stimulation and inhibited by TCR ligation

1998 • 34 citations

Interferon-?? Modifies Cytokine Release In Vitro by Monocytes from Surgical Patients

2001 • 28 citations

The Potential Pattern of Circulating Lymphocytes TH1/TH2 Is Not Altered After Multiple Injuries

2000 • 28 citations

Altered T cell cytokine production following mechanical trauma.

1998 • 24 citations

Endoscopic vs conventional hernia repair from an immunologic point of view

1999 • 21 citations

Interleukin‐4 Treatment Restores Cellular Immunity After Ethanol Exposure and Burn Injury

2002 • 20 citations

Sepsis after Severe Injury Interrupts Caspase-Dependent Processing of Interleukin-18

2000 • 14 citations

Effects of Perioperative Recombinant Human IFN-γ(rHuIFN-γ) ApplicationIn Vivoon T Cell Response

2003 • 9 citations