Use of Intracellular Cytokine Staining and Bacterial Superantigen to Document Suppression of the Adaptive Immune System in Injured Patients

The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination.

1994 • 6,682 citations

Multiple Organ Failure Pathophysiology and Potential Future Therapy

1992 • 1,398 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4+ T Lymphocytes in Humans

2001 • 865 citations

Major Injury Leads to Predominance of the T Helper-2 Lymphocyte Phenotype and Diminished Interleukin-12 Production Associated with Decreased Resistance to Infection

1995 • 503 citations

Postinjury Multiple Organ Failure

1996 • 490 citations

Toward an Epidemiology and Natural History of SIRS (Systemic Inflammatory Response Syndrome)

1992 • 479 citations

Overexpression of Bcl-2 in Transgenic Mice Decreases Apoptosis and Improves Survival in Sepsis

1999 • 354 citations

Depression of Cellular Immunity After Major Injury

1986 • 252 citations

The Immunologic Response To Injury

2001 • 233 citations

Major Injury Induces Increased Production of Interleukin-10 by Cells of the Immune System With a Negative Impact on Resistance to Infection

1997 • 221 citations

Inadequate Interleukin 2 Production

1984 • 211 citations

Depressed Interferon Gamma Production and Monocyte HLA-DR Expression After Severe Injury

1988 • 195 citations

Mechanism of Enhanced Susceptibility to Sepsis Following Hemorrhage

1994 • 168 citations

Interferon Gamma-1b in the Treatment of Compensatory Anti-inflammatory Response Syndrome

1997 • 155 citations

Interleukin-10 Is Associated with the Development of Sepsis in Trauma Patients

1996 • 149 citations

Early postoperative compensatory anti-inflammatory response syndrome is associated with septic complications after major surgical trauma in patients with cancer

2002 • 140 citations

Dominance of T-Helper 2–Type Cytokines After Severe Injury

1996 • 123 citations

Immunodepression in sepsis and SIRS assessed by ex vivo cytokine production is not a generalized phenomenon: a review.

2001 • 122 citations

Association of Interleukin-4 Plasma Levels With Traumatic Injury and Clinical Course

1995 • 99 citations

Cell-Mediated Immunity after Thermal Injury

1973 • 99 citations

Induction of Global Anergy Rather Than Inhibitory Th2 Lymphokines Mediates Posttrauma T Cell Immunodepression

2000 • 96 citations

SEVERE INJURY TRIGGERS ANTIGEN-SPECIFIC T-HELPER CELL DYSFUNCTION

1999 • 73 citations

Relationships between T Lymphocyte Apoptosis and Anergy Following Trauma

2000 • 71 citations

Immune deficiency following thermal trauma is associated with apoptotic cell death

1995 • 67 citations

Mechanisms of immunosuppression associated with severe nonthermal traumatic injuries in man: Production of interleukin 1 and 2

1986 • 58 citations

DIFFERENTIAL EXPRESSION AND TISSUE COMPARTMENTALIZATION OF THE INFLAMMATORY RESPONSE FOLLOWING THERMAL INJURY

2002 • 56 citations

Postburn Constitutional Changes in T-cell Reactivity Occur in CD8 sup + Rather than in CD4 sup + Cells

1997 • 55 citations

EX VIVO T-LYMPHOCYTE DERIVED CYTOKINE PRODUCTION IN SIRS PATIENTS IS INFLUENCED BY EXPERIMENTAL PROCEDURES

2000 • 50 citations

INTERFERON-?? PRODUCTION IS SUPPRESSED IN THERMALLY INJURED MICE: DECREASED PRODUCTION OF REGULATORY CYTOKINES AND CORRESPONDING RECEPTORS

2002 • 47 citations

INJURY PRIMES THE IMMUNE SYSTEM FOR AN ENHANCED AND LETHAL T-CELL RESPONSE AGAINST BACTERIAL SUPERANTIGEN

1999 • 45 citations

The Potential Pattern of Circulating Lymphocytes TH1/TH2 Is Not Altered After Multiple Injuries

2000 • 28 citations

Superantigen concomitantly induces Th1 cytokine genes and the ability to shut off their expression on re-exposure to superantigen

2002 • 20 citations

Role and regulation of IL-12 in the in vivo response to staphylococcal enterotoxin B

1999 • 19 citations

Strong induction of tyrosine phosphorylation, intracellular calcium, nuclear transcription factors and interferonγ, but weak induction of IL-2 in naı̈ve T cells stimulated by bacterial superantigen

2002 • 2 citations