Alternative splicing of β-tropomyosin pre-mRNA: multiple cis-elements can contribute to the use of the 5′- and 3′-splice sites of the nonmuscle/smooth muscle exon 6

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

Exon definition may facilitate splice site selection in RNAs with multiple exons.

1990 • 726 citations

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

1992 • 724 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

Recognition of cap structure in splicing in vitro of mRNA precursors

1984 • 575 citations

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

1990 • 500 citations

A role for exon sequences and splice-site proximity in splice-site selection

1986 • 494 citations

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

1990 • 454 citations

Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing

1993 • 407 citations

Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor.

1989 • 375 citations

The role of exon sequences in splice site selection.

1993 • 367 citations

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.

1990 • 359 citations

An RNA Processing Activity That Debranches RNA Lariats

1985 • 300 citations

Exon Definition May Facilitate Splice Site Selection in RNAs with Multiple Exons

1990 • 269 citations

Mechanisms of Alternative Pre-mRNA Splicing

1991 • 257 citations

Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.

1993 • 241 citations

Mutually exclusive splicing of α-tropomyosin exons enforced by an unusual lariat branch point location: Implications for constitutive splicing

1989 • 238 citations

The role of the mammalian branchpoint sequence in pre-mRNA splicing.

1988 • 215 citations

Control of Alternative Splicing by the Differential Binding of U1 Small Nuclear Ribonucleoprotein Particle

1991 • 191 citations

Nonmuscle and Muscle Tropomyosin Isoforms Are Expressed from a Single Gene by Alternative RNA Splicing and Polyadenylation

1986 • 190 citations

The Cardiac troponin T Alternative Exon Contains a Novel Purine-Rich Positive Splicing Element

1993 • 189 citations

UACUAAC is the preferred branch site for mammalian mRNA splicing.

1989 • 180 citations

Polypyrimidine tract binding protein interacts with sequences involved in alternative splicing of beta-tropomyosin pre-mRNA.

1992 • 157 citations

Tissue-Specific Splicing in Vivo of the β-Tropomyosin Gene: Dependence on an RNA Secondary Structure

1991 • 156 citations

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989 • 151 citations

RNA Secondary Structure Repression of a Muscle-Specific Exon in HeLa Cell Nuclear Extracts

1991 • 149 citations

Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells?

1991 • 146 citations

Alpha-tropomyosin mutually exclusive exon selection: competition between branchpoint/polypyrimidine tracts determines default exon choice.

1991 • 146 citations

A role for exon sequences in alternative splicing of the human fibronection gene

1987 • 145 citations

Factors influencing alternative splice site utilization in vivo.

1987 • 120 citations

Alternative splicing of tropomyosin pre-mRNAs in vitro and in vivo.

1988 • 115 citations

The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3′ splice site in alternative splicing.

1988 • 105 citations

Exon mutations that affect the choice of splice sites used in processing the SV40 late transcripts

1985 • 103 citations

Nucleotide substitutions within the cardiac troponin T alternative exon disrupt pre-mRNA alternative splicing

1989 • 101 citations

Identification of two distinct intron elements involved in alternative splicing of beta-tropomyosin pre-mRNA.

1990 • 100 citations

In vitro splicing of mutually exclusive exons from the chicken beta-tropomyosin gene: role of the branch point location and very long pyrimidine stretch.

1990 • 97 citations

Alternative processing of bovine growth hormone mRNA is influenced by downstream exon sequences.

1989 • 97 citations

Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites

1987 • 93 citations

Cooperation of Pre-mRNA Sequence Elements in Splice Site Selection

1992 • 90 citations

Exon as well as Intron Sequences Are cis-Regulating Elements for the Mutually Exclusive Alternative Splicing of the β Tropomyosin Gene

1990 • 87 citations

The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA.

1987 • 84 citations

Autoregulation and multifunctionality among trans-acting factors that regulate alternative pre-mRNA processing.

1992 • 80 citations

Alternative splicing of SV40 early pre-mRNA is determined by branch site selection.

1988 • 77 citations

Modulation of Exon Skipping and Inclusion by Heterogeneous Nuclear Ribonucleoprotein A1 and Pre-mRNA Splicing Factor SF2/ASF

1993 • 76 citations

Unusual branch point selection in processing of human growth hormone pre-mRNA.

1988 • 72 citations

A Sequential splicing mechanism promotes selection of an optimal exon by repositioning a downstream 5' splice site in preprotachykinin pre-mRNA.

1990 • 69 citations

Regulation of Alternative Splicing

1990 • 61 citations

In vitro splicing of cardiac troponin T precursors. Exon mutations disrupt splicing of the upstream intron.

1992 • 51 citations

In vitro splicing of adenovirus E1A transcripts: characterization of novel reactions and of multiple branch points abnormally far from the 3′ splice site

1988 • 50 citations

Alternative Processing of Bovine Growth Hormone mRNA Is Influenced by Downstream Exon Sequences

1989 • 50 citations

Factors Influencing Alternative Splice Site Utilization In Vivo

1987 • 48 citations

Combinatorial splicing of exon pairs by two-site binding of U1 small nuclear ribonucleoprotein particle.

1991 • 42 citations

In vivo splicing of the beta tropomyosin pre-mRNA: a role for branch point and donor site competition.

1992 • 41 citations

Unusual Branch Point Selection in Processing of Human Growth Hormone Pre-mRNA

1988 • 35 citations

The Natural 5′ Splice Site of Simian Virus 40 Large T Antigen can be improved by increasing the base Complementarity to U1 RNA

1987 • 29 citations

RNA processing

1992 • 25 citations

Cis-elements involved in alternative splicing in the rat β-tropomyosin gene: the 3′-splice site of the skeletal muscle exon 7 is the major site of blockage in nonmuscle cells

1993 • 24 citations

Combinatorial Splicing of Exon Pairs by Two-Site Binding of U1 Small Nuclear Ribonucleoprotein Particle

1991 • 18 citations

In Vivo Splicing of the β Tropomyosin Pre-mRNA: A Role for Branch Point and Donor Site Competition

1992 • 14 citations