Two Different Sequence Elements within Exon 4 Are Necessary for Calcitonin-Specific Splicing of the Human Calcitonin/Calcitonin Gene-Related Peptide I Pre-mRNA

Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information

1981 • 3,596 citations

Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

1983 • 2,298 citations

Exon definition may facilitate splice site selection in RNAs with multiple exons.

1990 • 726 citations

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

1992 • 724 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides

1989 • 685 citations

A role for exon sequences and splice-site proximity in splice-site selection

1986 • 494 citations

Heterogeneous Nuclear Ribonucleoproteins: Role in RNA Splicing

1986 • 399 citations

The role of exon sequences in splice site selection.

1993 • 367 citations

Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns.

1989 • 349 citations

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.

1991 • 338 citations

Control of doublesex Alternative Splicing by transformer and transformer-2 in Drosophila

1991 • 333 citations

The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster

1988 • 284 citations

Effects of RNA secondary structure on alternative splicing of Pre-mRNA: Is folding limited to a region behind the transcribing RNA polymerase?

1988 • 280 citations

Alternative splicing caused by RNA secondary structure

1985 • 274 citations

Characterization of cDNAs encoding the polypyrimidine tract-binding protein.

1991 • 257 citations

RNA binding specificity of hnRNP proteins: a subset bind to the 3′ end of introns.

1988 • 251 citations

Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro

1991 • 244 citations

Alternative mRNA Splicing

1992 • 219 citations

Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites.

1984 • 202 citations

Positive Control of Pre-mRNA Splicing in Vitro

1992 • 199 citations

The Cardiac troponin T Alternative Exon Contains a Novel Purine-Rich Positive Splicing Element

1993 • 189 citations

Regulation of doublesex pre-mRNA processing occurs by 3'-splice site activation.

1991 • 184 citations

Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns.

1990 • 169 citations

Binding of the Drosophila transformer and transformer-2 proteins to the regulatory elements of doublesex primary transcript for sex-specific RNA processing.

1992 • 168 citations

Structural basis for the regulation of splicing of a yeast messenger RNA

1991 • 162 citations

Ectopic expression of the female transformer gene product leads to female differentiation of chromosomally male drosophila

1988 • 157 citations

Tissue-Specific Splicing in Vivo of the β-Tropomyosin Gene: Dependence on an RNA Secondary Structure

1991 • 156 citations

The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5' splice site control U1 snRNP binding.

1992 • 154 citations

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989 • 151 citations

Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma.

1985 • 151 citations

RNA Secondary Structure Repression of a Muscle-Specific Exon in HeLa Cell Nuclear Extracts

1991 • 149 citations

Alternative production of calcitonin and CGRP mRNA is regulated at the calcitonin-specific splice acceptor

1989 • 149 citations

A role for exon sequences in alternative splicing of the human fibronection gene

1987 • 145 citations

Differential Binding of Heterogeneous Nuclear Ribonucleoproteins to mRNA Precursors prior to Spliceosome Assembly In Vitro

1992 • 142 citations

Amount of RNA secondary structure required to induce an alternative splice.

1987 • 128 citations

The role of branchpoint and 3'-exon sequences in the control of balanced splicing of avian retrovirus RNA.

1991 • 112 citations

Nucleotide substitutions within the cardiac troponin T alternative exon disrupt pre-mRNA alternative splicing

1989 • 101 citations

A novel exon mutation in the human beta-hexosaminidase beta subunit gene affects 3' splice site selection.

1992 • 98 citations

Alternative splicing of beta-tropomyosin pre-mRNA: cis-acting elements and cellular factors that block the use of a skeletal muscle exon in nonmuscle cells.

1991 • 98 citations

Alternative processing of bovine growth hormone mRNA is influenced by downstream exon sequences.

1989 • 97 citations

Exon as well as Intron Sequences Are cis-Regulating Elements for the Mutually Exclusive Alternative Splicing of the β Tropomyosin Gene

1990 • 87 citations

Unexpected point mutations activate cryptic 3' splice sites by perturbing a natural secondary structure within a yeast intron.

1991 • 81 citations

A native RNA secondary structure controls alternative splice-site selection and generates two human growth hormone isoforms.

1992 • 80 citations

A secondary structure at the 3′ splice site affects thein vitrosplicing reaction of mouse immunoglobulin μ chain pre-mRNAs

1989 • 73 citations

The 216-nucleotide intron of the E1A pre-mRNA contains a hairpin structure that permits utilization of unusually distant branch acceptors.

1989 • 73 citations

Identification of exon sequences and an exon binding protein involved in alternative RNA splicing of calcitonin/CGRP

1992 • 64 citations

Regulation of Alternative Splicing

1990 • 61 citations

Binding of the Drosophila transformer-2 proteins to the regulatory elements of doublesex primary transcript for sex-specific RNA processing

1992 • 58 citations

In vitro splicing of cardiac troponin T precursors. Exon mutations disrupt splicing of the upstream intron.

1992 • 51 citations

Uridine branch acceptor is acis-acting element involved in regulation of the alternative processing of calcitonin/CGRP-I pre-mRNA

1990 • 51 citations

Unusual branch point selection involved in splicing of the alternatively processed Calcitonin/CGRP-I pre-mRNA

1988 • 50 citations

Identification of a cis-acting sequence required for germ line-specific splicing of the P element ORF2-ORF3 intron.

1991 • 47 citations

Identification of a specific exon sequence that is a major determinant in the selection between a natural and a cryptic 5' splice site.

1991 • 44 citations

Model for alternative RNA processing in human calcitonin gene expression

1986 • 40 citations

Regulation of tissue-specific splicing of the calcitonin/calcitonin gene-related peptide gene by RNA-binding proteins.

1993 • 35 citations

A novel calcitonin-encoding mRNA is produced by alternative processing of calcitonin/calcitonin gene-related peptide-I pre-mRNA.

1992 • 34 citations

Integrity of the Exon 6 Sequence Is Essential for Tissue-Specific Alternative Splicing of Human Leukocyte Common Antigen Pre-mRNA

1989 • 34 citations

Validation of anin vitroRNA processing system for CT/CGRP precursor mRNA

1991 • 27 citations

Model for tissue specific Calcitonin/CGRP-I RNA processing fromin vitroexperiments

1988 • 23 citations

Repositioning of an alternative exon sequence of mouse IgM pre-mRNA activates splicing of the preceding intron.

1991 • 23 citations

Calcitonin Exon Sequences Influence Alternative RNA Processing

1990 • 22 citations

In vitro splicing analysis of mini-gene constructs of the alternatively processed human calcitonin/CGRP-I pre-mRNA

1989 • 14 citations

Deregulation of alternative processing of calcitonin/CGRP-I pre-mRNA by a single point mutation

1991 • 11 citations