Gene inhibition using antisense oligodeoxynucleotides

In vitro selection of RNA molecules that bind specific ligands

1990 • 9,093 citations

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

1992 • 2,361 citations

Antisense Oligonucleotides as Therapeutic Agents—Is the Bullet Really Magical?

1993 • 1,306 citations

High Levels of HIV-1 in Plasma During All Stages of Infection Determined By Competitive PCR

1993 • 1,263 citations

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

1990 • 769 citations

Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo

1992 • 749 citations

Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

1993 • 734 citations

Current concepts in antisense drug design

1993 • 566 citations

Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.

1991 • 551 citations

Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms.

1991 • 468 citations

Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia.

1993 • 459 citations

Inhibition of axonal growth by SNAP-25 antisense oligonucleotides in vitro and in vivo

1993 • 440 citations

Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines

1993 • 405 citations

Modified deoxyoligonucleotides stable to exonuclease degradation in serum

1991 • 356 citations

Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides.

1994 • 290 citations

Inhibition of protein kinase C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters.

1994 • 289 citations

Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression.

1993 • 268 citations

Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides.

1994 • 250 citations

Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligodeoxynucleotides.

1994 • 250 citations

Ablation of transplanted HTLV-I tax-transformed tumors in mice by antisense inhibition of NF-kappa B

1993 • 249 citations

Specificity of antisense oligonucleotides in vivo.

1992 • 248 citations

Transcatheter delivery of c-myc antisense oligomers reduces neointimal formation in a porcine model of coronary artery balloon injury.

1994 • 245 citations

Intracellular disposition and metabolism of fluorescently-labled unmodified and modified oligouncleotides microijjected into mammalian cells

1993 • 239 citations

Ablation of Transplanted HTLV-I Tax-Transformed Tumors in Mice by Antisense Inhibition of NF-κB

1992 • 207 citations

Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region

1993 • 205 citations

Selective loss of δ opioid analgesia and binding by antisense oligodeoxynucleotides to a δ opioid receptor

1994 • 192 citations

Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide.

1994 • 176 citations

Antisense oligonucleotide eliminates in vivo expression of c-fos in mammalian brain

1992 • 158 citations

Systemic Administration of a Phosphorothioate Oligonucleotide with a Sequence Complementary to p53 for Acute Myelogenous Leukemia and Myelodysplastic Syndrome: Initial Results of a Phase I Trial

1993 • 146 citations

In vivo inhibition of duck hepatitis B virus replication and gene expression by phosphorothioate modified antisense oligodeoxynucleotides.

1993 • 144 citations

Sequence-independent induction of Sp1 transcription factor activity by phosphorothioate oligodeoxynucleotides.

1994 • 142 citations

Antisense proliferating cell nuclear antigen oligonucleotides inhibit intimal hyperplasia in a rat carotid artery injury model.

1994 • 120 citations

Suppression of Neointimal Smooth Muscle Cell Accumulation in Vivo by Antisense cdc2 and cdk2 Oligonucleotides in Rat Carotid Artery

1994 • 116 citations

Purine nucleosides and nucleotides stimulate proliferation of a wide range of cell types

1992 • 109 citations

Intracerebral administration of antisense oligodeoxynucleotides to GAD65 and GAD67 mRNAs modulate reproductive behavior in the female rat

1994 • 101 citations

Oligodeoxynucleotides interact with recombinant CD4 at multiple sites.

1993 • 95 citations

In vivo administration of an oligodeoxynucleotide antisense to the D2 dopamine receptor messenger RNA inhibits D2 dopamine receptor-mediated behavior and the expression of D2 dopamine receptors in mouse striatum.

1994 • 91 citations

Use of an antisense oligonucleotide to inhibit expression of a mutated human procollagen gene (COL1A1) in transfected mouse 3T3 cells

1993 • 90 citations

Biologic and therapeutic significance of MYB expression in human melanoma.

1994 • 85 citations

Development of frequency-selective domains in inferior colliculus of normal and neonatally noise-exposed rats

1994 • 79 citations

Inhibition of kinesin synthesis and rapid anterograde axonal transport in vivo by an antisense oligonucleotide

1993 • 68 citations

Inhibition of Human Immunodeficiency Virus Type-1 env Expression by C-5 Propyne Oligonucleotides Specific for Rev-Response Element Stem-Loop V

1994 • 60 citations

Human T-cell leukemia virus type I tax transformation is associated with increased uptake of oligodeoxynucleotides in vitro and in vivo.

1992 • 59 citations

In Vivo Modulation of N-myc Expression by Continuous Perfusion with an Antisense Oligonucleotide

1991 • 58 citations

Anti-sense oligodeoxynucleotides--promises and pitfalls.

1992 • 54 citations

Potent inhibition of Epstein-Barr virus by phosphorothioate oligodeoxynucleotides without sequence specification

1993 • 31 citations

Ventral tegmental area (VTA) injections of tyrosine hydroxylase phosphorothioate antisense oligonucleotide suppress operant behavior in rats

1994 • 28 citations