BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis

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1997 • 5,038 citations

Requirement of mammalian DNA polymerase-β in base-excision repair

1996 • 820 citations

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1)

1997 • 779 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

Cancer Chemotherapy: Principles and Practice

1990 • 568 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

DNA damage tolerance, mismatch repair and genome instability

1994 • 308 citations

Mammalian base excision repair and DNA polymerase beta

1998 • 275 citations

Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding.

1993 • 270 citations

Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent.

2000 • 246 citations

Repair of DNA containing O ⁶ ‐alkylguanine

1992 • 241 citations

A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress

1994 • 221 citations

Transfection and expression of human O⁶-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

1991 • 219 citations

Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex−, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

1997 • 190 citations

Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing.

1996 • 186 citations

Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells.

1989 • 158 citations

Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation.

1998 • 139 citations

p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents

1998 • 138 citations

Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage.

1999 • 134 citations

O6-alkylguanine DNA lesions trigger apoptosis

1998 • 128 citations

Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents — a case of imbalanced DNA repair

1995 • 122 citations

Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes

1996 • 121 citations

Site-directed mutagenesis of the human DNA repair enzyme HAP1: identification of residues important for AP endonuclease and RNase H activity

1995 • 119 citations

Alkylpurine–DNA–N-Glycosylase Knockout Mice Show Increased Susceptibility to Induction of Mutations by Methyl Methanesulfonate

1998 • 112 citations

Contribution of O⁶‐alkylguanine and N‐alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: New insights gained from studies of genetically engineered mammalian cell lines

1993 • 112 citations

Nuclear Translocation of Mismatch Repair Proteins MSH2 and MSH6 as a Response of Cells to Alkylating Agents

2000 • 103 citations

Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1

1999 • 102 citations

Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines

1998 • 98 citations

Deletion analysis of human AP-endonuclease: minimum sequence required for the endonuclease activity

1998 • 97 citations

Exposure of humans to endogenous N-nitroso compounds: implications in cancer etiology

1990 • 96 citations

Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting

1997 • 95 citations

The DNA repair activity of human redox/repair protein APE/Ref-1 is inactivated by phosphorylation.

1997 • 88 citations

Induction of murine O6-alkylguanine-DNA-alkyltransferase in response to ionising radiation is p53 gene dose dependent.

1996 • 84 citations

Transcriptional Activation of Apurinic/Apyrimidinic Endonuclease (Ape, Ref-1) by Oxidative Stress Requires CREB

1999 • 78 citations

Negative Regulation of the Major Human AP-Endonuclease, a Multifunctional Protein^,

1996 • 74 citations

Heterogeneous repair of N -methylpurines at the nucleotide level in normal human cells 1 1Edited by M. Yahiv

1998 • 71 citations

A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells

1995 • 68 citations

Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells

1992 • 61 citations

On the quantitative relationship between O6-ethylguanine residues, in genomic DNA and production of sister-chromatid exchanges, mutations and lethal events in a Mer− human tumor cell line

1994 • 58 citations

Activity of the DNA repair protein O6-methylguanine-DNA methyltransferase in human tumor and corresponding normal tissue.

1996 • 56 citations

Expression of the E.coli 3-methyladenine DNA glycosylase I gene in mammalian cells reduces the toxic and mutagenic effects of methylating agents.

1992 • 46 citations

Expression of yeast but not human apurinic/apyrimidinic endonuclease renders Chinese hamster cells more resistant to DNA damaging agents

1997 • 45 citations

Critical steps in alkylation-induced aberration formation

1998 • 45 citations

Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, thresholds and defense mechanisms

1998 • 40 citations

DNA repair and chromosomal stability in the alkylating agent-hypersensitive Chinese hamster cell line 27-1

1990 • 18 citations

Isolation and Analysis of Inducibility of the Rat N-Methylpurine-DNA Glycosylase Promoter

1996 • 15 citations