Constitutive expression and inducibility of O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in rat liver cells exhibiting different status of differentiation

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

DNA REPAIR ENZYMES

1988 • 822 citations

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

Characterization of differentiated and dedifferentiated clones from a rat hepatoma

1975 • 381 citations

The Prevention of Thymic Lymphomas in Transgenic Mice by Human O ⁶ -Alkylguanine-DNA Alkyltransferase

1993 • 238 citations

Transfection and expression of human O⁶-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

1991 • 219 citations

Regulation of Tyrosine α-Ketoglutarate Transaminase in Rat Liver

1967 • 199 citations

Regulation of Repair of Alkylation Damage in Mammalian Genomes

1993 • 164 citations

Characterization of the promoter region of the human O⁶-methylguanine-DNA methyltransferase gene

1991 • 142 citations

Inducibility of the DNA Repair Gene Encoding O⁶-Methylguanine- DNA Methyltransferase in Mammalian Cells by DNA-Damaging Treatments

1991 • 138 citations

Importance of the DNA repair enzyme O6-alkyl guanine alkyltransferase (AT) in cancer chemotherapy

1988 • 119 citations

Immunofluorescence analysis of the time-course of extinction, reexpression, and activation of albumin production in rat hepatoma-mouse fibroblast heterokaryons and hybrids.

1981 • 114 citations

Contribution of O⁶‐alkylguanine and N‐alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: New insights gained from studies of genetically engineered mammalian cell lines

1993 • 112 citations

Inducibility of the DNA repair gene encoding O6-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments.

1991 • 111 citations

Perifused monolayer cultures of rat hepatocytes as an improved in vitro system for studies on ureogenesis

1979 • 88 citations

Cell specificity in hepatocarcinogenesis: preferential accumulation of O6-methylguanine in target cell DNA during continuous exposure to rats to 1,2-dimethylhydrazine.

1982 • 77 citations

Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells

1992 • 61 citations

Enhancement of O6-methylguanine-DNA-methyltransferase activity induced by various treatments in mammalian cells.

1986 • 57 citations

O⁶-Methylguanine methyltransferase activity is increased in rat tissues by ionising radiation

1985 • 49 citations

Phenobarbital, dexamethasone and benzanthracene induce several cytochrome P450 mRNAs in rat hepatoma cells

1988 • 45 citations

Irradiation-induced expression of O6-methylguanine-DNA methyltransferase in mammalian cells.

1992 • 41 citations

Isolation and cDNA cloning of a rat; O⁶-alkyllguanine-DNA-alkyltransferase gene, molecelar analysis of expression in rat liver

1991 • 40 citations

Induction of proteins involved in the repair of alkylated bases in mammalian cells by DNA-damaging agents

1990 • 39 citations

Ionizing radiation induces O⁶-alkylguanine-DNA-alkyltransferase mRNA and activity in mouse tissues

1993 • 28 citations

Increase of O6-methylguanine-DNA-methyltransferase and N3-methyladenine glycosylase RNA transcripts in rat hepatoma cells treated with DNA-damaging agents

1991 • 27 citations

Properties and Mechanism of Action of Eukaryotic 3-Methyladenine-DNA Glycosylases

1987 • 26 citations

Expression of human O⁶‐methylguanine‐DNA methyltransferase in chinese hamster ovary cells and restoration of cellular resistance to certain N‐nitroso compounds

1991 • 20 citations

In vitro induction of O⁶-methylguanine-DNA methyltransferase in C3H/10T1/2 cells by X-rays is inhibited by nitrogen

1988 • 17 citations

The capacity of rat hepatoma cell lines for O⁶-methylguanine-DNA repair correlates with their status of differentiation

1984 • 14 citations

Enhancement of 1,3-bis(2-chloroethyl)-1-nitrosourea resistance by gamma-irradiation or drug pretreatment in rat hepatoma cells.

1991 • 12 citations

X-Ray Induction of O 6 -Alkylguanine-DNA Alkyltransferase Protects against Some of the Biological Effects of N-Methyl-N prime -Nitro-N-Nitrosoguanidine in C3H 10T1/2 Cells

1991 • 9 citations

Changes in the expression of differentiated functions during long-term cultivation of rat hepatoma cells

1983 • 4 citations