Loss of Invariant Chain Protects Nonobese Diabetic Mice against Type 1 Diabetes

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

2005 • 783 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

Cellular and genetic mechanisms of self tolerance and autoimmunity

2005 • 671 citations

The Murine Autoimmune Diabetes Model: NOD and Related Strains

1992 • 498 citations

Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

2001 • 406 citations

Structure of a human insulin peptide–HLA-DQ8 complex and susceptibility to type 1 diabetes

2001 • 386 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Invariant Chain Structure and MHC Class II Function

1996 • 374 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain

1990 • 334 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Prevention of autoimmune insulitis by expression of I–E molecules in NOD mice

1987 • 308 citations

A defect in central tolerance in NOD mice

2001 • 272 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules

2004 • 256 citations

A Structural Framework for Deciphering the Link Between I-A ^g7 and Autoimmune Diabetes

2000 • 256 citations

Dynamics of Pathogenic and Suppressor T Cells in Autoimmune Diabetes Development

2003 • 243 citations

Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells

2004 • 238 citations

Natural regulatory T cells and self-tolerance

2005 • 234 citations

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.

1996 • 217 citations

Identification of MHC Class II-Restricted Peptide Ligands, Including a Glutamic Acid Decarboxylase 65 Sequence, that Stimulate Diabetogenic T Cells from Transgenic BDC2.5 Nonobese Diabetic Mice

2001 • 213 citations

Genetic Protection from the Inflammatory Disease Type 1 Diabetes in Humans and Animal Models

2001 • 205 citations

Prevention of diabetes in non-obese diabetic I-Ak transgenic mice

1990 • 204 citations

A Mechanism for the Major Histocompatibility Complex–linked Resistance to Autoimmunity

1997 • 202 citations

Back to Central Tolerance

2004 • 202 citations

Structural Basis of Peptide Binding and Presentation by the Type I Diabetes-Associated MHC Class II Molecule of NOD Mice

2000 • 197 citations

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.

1994 • 196 citations

Cathepsin L Regulates CD4+ T Cell Selection Independently of Its Effect on Invariant Chain

2002 • 186 citations

Proteolysis in MHC Class II Antigen Presentation

2000 • 181 citations

Defective Central Tolerance Induction in NOD Mice: Genomics and Genetics

2005 • 179 citations

Requirement for Diverse, Low-Abundance Peptides in Positive Selection of T Cells

1999 • 151 citations

HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells.

1992 • 148 citations

Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease.

1993 • 146 citations

A role for calnexin (IP90) in the assembly of class II MHC molecules.

1994 • 144 citations

Natural peptides selected by diabetogenic DQ8 and murine I-Ag7 molecules show common sequence specificity

2005 • 140 citations

Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes

2002 • 140 citations

The I-Ag7 MHC Class II Molecule Linked to Murine Diabetes Is a Promiscuous Peptide Binder

2000 • 134 citations

An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells.

1993 • 118 citations

Diversity of Endogenous Epitopes Bound to MHC Class II Molecules Limited by Invariant Chain

1994 • 116 citations

Major Histocompatibility Complex Class II Molecules Can Protect from Diabetes by Positively Selecting T Cells with Additional Specificities

1998 • 109 citations

Allelic differences affecting invariant chain dependency of MHC class II subunit assembly

1995 • 106 citations

Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.

1994 • 104 citations

Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules.

1996 • 102 citations

Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells.

1992 • 98 citations

Developing and shedding inhibitions: how MHC class II molecules reach maturity

1996 • 97 citations

Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity

2001 • 90 citations

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice

2005 • 84 citations

Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms

1995 • 80 citations

pH-dependent Peptide Binding Properties of the Type I Diabetes–associated I-Ag7 Molecule: Rapid Release of CLIP at an Endosomal pH

1999 • 79 citations

Analysis of the Role of Variation of Major Histocompatibility Complex Class II Expression on Nonobese Diabetic (NOD) Peripheral T Cell Response

1998 • 76 citations

Dendritic cell maturation and antigen presentation in the absence of invariant chain

1998 • 57 citations

Antiviral Immune Responses of Mice Lacking MHC Class II or Its Associated Invariant Chain

1996 • 55 citations

Potent effects of low levels of MHC class II-associated invariant chain on CD4+ T cell development

1995 • 51 citations

In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DM

1997 • 51 citations

The influence of invariant chain on the positive selection of single T cell receptor specificities

1995 • 49 citations

Failure of a protective major histocompatibility complex class II molecule to delete autoreactive T cells in autoimmune diabetes.

1993 • 49 citations

Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells

1996 • 47 citations

Phenotype and function of CD4+ T cells in mice lacking invariant chain.

1996 • 44 citations

Preferential Th1 Immune Response in Invariant Chain-Deficient Mice

2002 • 40 citations

The role of self-peptides in the development of CD4+ CD25+ regulatory T cells

2005 • 39 citations

BALB/c Invariant Chain Mutant Mice Display Relatively Efficient Maturation of CD4+ T Cells in the Periphery and Secondary Proliferative Responses Elicited upon Peptide Challenge

1999 • 37 citations

Selectivity of the major histocompatibility complex class II presentation pathway of cortical thymic epithelial cell lines

1997 • 34 citations

Relaxed DM Requirements During Class II Peptide Loading and CD4+ T Cell Maturation in BALB/c Mice

2001 • 34 citations

T Helper Subset Differentiation in the Absence of Invariant Chain

1997 • 30 citations

Functional in vivo MHC class II loading by endogenously synthesized glycoprotein during viral infection.

1997 • 28 citations

The antigen presentation pathway in medullary thymic epithelial cells, but not that in cortical thymic epithelial cells, conforms to the endocytic pathway

1998 • 26 citations

Dissecting MHC Class II Export, B Cell Maturation, and DM Stability Defects in Invariant Chain Mutant Mice

2004 • 19 citations

MHC Class II-Associated Invariant Chain Isoforms Regulate Pulmonary Immune Responses

2003 • 19 citations

CLIP-derived self peptides bound to MHC class II molecules of medullary thymic epithelial cells differ from those of cortical thymic epithelial cells in their diversity, length, and C-terminal processing

2000 • 17 citations