CLIP-derived self peptides bound to MHC class II molecules of medullary thymic epithelial cells differ from those of cortical thymic epithelial cells in their diversity, length, and C-terminal processing

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

1998 • 654 citations

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.

1991 • 595 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication.

1981 • 531 citations

Cellular Interactions in Thymocyte Development

1996 • 503 citations

The role of ARF and Rab GTPases in membrane transport

1999 • 496 citations

Rab GTPases coordinate endocytosis

2000 • 447 citations

AP-3: an adaptor-like protein complex with ubiquitous expression

1997 • 389 citations

Clathrin and adaptors

1998 • 383 citations

Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells

1998 • 378 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation

1998 • 266 citations

Cathepsin S Controls the Trafficking and Maturation of Mhc Class II Molecules in Dendritic Cells

1999 • 227 citations

Cathepsins and compartmentalization in antigen presentation

2000 • 204 citations

Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells.

1984 • 190 citations

Degradation of Mouse Invariant Chain: Roles of Cathepsins S and D and the Influence of Major Histocompatibility Complex Polymorphism

1997 • 188 citations

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy.

1994 • 184 citations

The role of lysosomal proteinases in MHC class Il‐mediated antigen processing and presentation

1999 • 179 citations

T-cell selection

1998 • 168 citations

Endosomal proteolysis and MHC class II function

1998 • 168 citations

Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody

1982 • 145 citations

Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain.

1991 • 145 citations

A Dominant-negative Clathrin Mutant Differentially Affects Trafficking of Molecules with Distinct Sorting Motifs in the Class II Major Histocompatibility Complex (MHC) Pathway

1998 • 135 citations

Self-antigen presentation by thymic stromal cells: a subtle division of labor

2000 • 135 citations

Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells

1994 • 135 citations

Self-Release of CLIP in Peptide Loading of HLA-DR Molecules

1995 • 100 citations

Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells.

1992 • 98 citations

The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif

1995 • 94 citations

The impact of the non‐classical MHC proteins HLA‐DM and HLA‐DO on loading of MHC class II molecules

1999 • 90 citations

A study of complexes of class II invariant chain peptide: Major histocompatibility complex class II molecules using a new complex‐specific monoclonal antibody

1996 • 62 citations

T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates.

1995 • 58 citations

Cloning of a Novel MHC-Encoded Serine Peptidase Highly Expressed by Cortical Epithelial Cells of the Thymus

1999 • 51 citations

Class II-Associated Invariant Chain Peptide-Independent Binding of Invariant Chain to Class II MHC molecules

1999 • 36 citations

Selectivity of the major histocompatibility complex class II presentation pathway of cortical thymic epithelial cell lines

1997 • 34 citations

Conformational variants of class II MHC/peptide complexes induced by N- and C-terminal extensions of minimal peptide epitopes

1999 • 31 citations

The antigen presentation pathway in medullary thymic epithelial cells, but not that in cortical thymic epithelial cells, conforms to the endocytic pathway

1998 • 26 citations

A novel cofactor produced by a thymic epithelial cell line: Promotion of proliferation of immature thymic lymphocytes by the presence of interleukin-1 and various mitogens

1991 • 20 citations