Dynamics of Pathogenic and Suppressor T Cells in Autoimmune Diabetes Development

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Regulatory T Cells

2000 • 1,827 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

2001 • 799 citations

Cutting Edge: CD4+CD25+ Regulatory T Cells Suppress Antigen-Specific Autoreactive Immune Responses and Central Nervous System Inflammation During Active Experimental Autoimmune Encephalomyelitis

2002 • 779 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 645 citations

The NOD mouse model of type 1 diabetes: As good as it gets?

1999 • 592 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 548 citations

T Cell Memory

2002 • 529 citations

The Murine Autoimmune Diabetes Model: NOD and Related Strains

1992 • 498 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

1995 • 428 citations

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

1999 • 426 citations

Strategies of Anti‐Cytokine Monoclonal Antibody Development: Immunoassay of IL‐10 and IL‐5 in Clinical Samples

1992 • 384 citations

The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR7

2002 • 383 citations

The function of human intercellular adhesion molecule‐1 (ICAM‐1) in the generation of an immune response

1988 • 351 citations

Checkpoints in the progression of autoimmune disease: lessons from diabetes models.

1996 • 340 citations

CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations

2000 • 334 citations

Immunohistochemical Characterization of Monocytes-Macrophages and Dendritic Cells Involved in the Initiation of the Insulitis and β-Cell Destruction in NOD Mice

1994 • 331 citations

Tumor necrosis factor-α regulation of CD4⁺C25⁺T cell levels in NOD mice

2002 • 252 citations

Tolerance to Islet Autoantigens in Type 1 Diabetes

2001 • 236 citations

Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium.

1993 • 218 citations

LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production.

1998 • 197 citations

Characterization of Peripheral Regulatory CD4+ T Cells That Prevent Diabetes Onset in Nonobese Diabetic Mice

2000 • 192 citations

Cell Death Mediators in Autoimmune Diabetes—No Shortage of Suspects

1997 • 177 citations

Cutting Edge: LFA-1 Interaction with ICAM-1 and ICAM-2 Regulates Th2 Cytokine Production

1998 • 160 citations

Mature mainstream TCR alpha beta+CD4+ thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse.

1998 • 134 citations

Deviation of pancreas‐infiltrating cells to Th2 by interleukin‐12 antagonist administration inhibits autoimmune diabetes

1997 • 126 citations

Understanding autoimmune diabetes: insights from mouse models

2002 • 118 citations

Intercellular Adhesion Molecule-1/LFA-1 Ligation Favors Human Th1 Development

2002 • 118 citations

Stimulation Through Intercellular Adhesion Molecule-1 Provides a Second Signal for T Cell Activation

2002 • 109 citations

Mature Mainstream TCRαβ+CD4+ Thymocytes Expressing L-Selectin Mediate “Active Tolerance” in the Nonobese Diabetic Mouse

1998 • 103 citations

Pancreas-Infiltrating Th1 Cells and Diabetes Develop in IL-12-Deficient Nonobese Diabetic Mice

1999 • 96 citations

Breaking self-tolerance in nonobese diabetic mice.

1996 • 88 citations

Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice

1994 • 84 citations

A key role for ICAM-1 in generating effector cells mediating inflammatory responses

2001 • 78 citations

Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells

1999 • 75 citations

Role of ICAM-1 in antigen presentation demonstrated by ICAM-1 defective mutants.

1990 • 73 citations

Prevention of autoimmune insulin-dependent diabetes in non-obese diabetic mice by anti-LFA-1 and anti-ICAM-1 mAb

1994 • 71 citations

Pathogenic and Protective Roles of CD45RBlow CD4+ Cells Correlate With Cytokine Profiles in the Spontaneously Autoimmune Diabetic Mouse

1996 • 68 citations

A Mechanism for IL-10-Mediated Diabetes in the Nonobese Diabetic (NOD) Mouse: ICAM-1 Deficiency Blocks Accelerated Diabetes

2000 • 65 citations

Cross-linking of ICAM-1 on T cells induces transient tyrosine phosphorylation and inactivation of cdc2 kinase.

1995 • 60 citations

Dominant Role of Intercellular Adhesion Molecule-1 in the Pathogenesis of Autoimmune Diabetes in Non-obese Diabetic Mice

2001 • 45 citations

IL-10 Deficiency Does Not Inhibit Insulitis and Accelerates Cyclophosphamide-Induced Diabetes in the Nonobese Diabetic Mouse

2000 • 36 citations

Lymphocyte Function Associated Antigen-1, Integrin α4, and L-Selectin Mediate T-Cell Homing to the Pancreas in the Model of Adoptive Transfer of Diabetes in NOD Mice

1996 • 34 citations

Polymorphisms in the Il12b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains

2002 • 33 citations