BALB/c Invariant Chain Mutant Mice Display Relatively Efficient Maturation of CD4+ T Cells in the Periphery and Secondary Proliferative Responses Elicited upon Peptide Challenge

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens

1979 • 993 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

1983 • 701 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1995 • 583 citations

Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.

1981 • 581 citations

The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.

1990 • 561 citations

A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication.

1981 • 531 citations

HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation

1992 • 522 citations

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1992 • 502 citations

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

1995 • 415 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Targeted disruption of the MHC class II Aa gene in C57BL/6 mice

1993 • 377 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

Invariant Chain Structure and MHC Class II Function

1996 • 374 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Production of soluble MHC class II proteins with covalently bound single peptides

1994 • 302 citations

Editing of the HLA-DR-peptide repertoire by HLA-DM.

1996 • 273 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

Crystal Structures of Two I-Ad–Peptide Complexes Reveal That High Affinity Can Be Achieved without Large Anchor Residues

1998 • 236 citations

Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain.

1986 • 226 citations

Interaction of peptide antigens and class II major histocompatibility complex antigens

1986 • 221 citations

HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules

1996 • 206 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

HLA-DM Acts as a Molecular Chaperone and Rescues Empty HLA-DR Molecules at Lysosomal pH

1997 • 199 citations

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

1992 • 197 citations

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.

1994 • 196 citations

Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells.

1984 • 190 citations

Degradation of Mouse Invariant Chain: Roles of Cathepsins S and D and the Influence of Major Histocompatibility Complex Polymorphism

1997 • 188 citations

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.

1995 • 186 citations

In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides

1994 • 185 citations

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy.

1994 • 184 citations

An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction

1993 • 182 citations

A Range of CD4 T Cell Tolerance: Partial Inactivation to Organ-Specific Antigen Allows Nondestructive Thyroiditis or Insulitis

1997 • 178 citations

Association Between HLA-DM and HLA-DR In Vivo

1996 • 149 citations

HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells.

1992 • 148 citations

Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.

1993 • 146 citations

Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum.

1996 • 146 citations

A role for calnexin (IP90) in the assembly of class II MHC molecules.

1994 • 144 citations

Characterization of a monoclonal antibody directed against the murine B lymphocyte receptor for IgE.

1987 • 143 citations

MHC class II function preserved by low-affinity peptide interactions preceding stable binding

1994 • 135 citations

Formation of a Highly Peptide-Receptive State of Class II MHC

1998 • 133 citations

Requirement for Invariant Chain in B Cell Maturation and Function

1996 • 130 citations

Ontogeny of Ia and IgD on IgM-bearing B lymphocytes in mice.

1977 • 129 citations

Antigen-unspecific B Cells and Lymphoid Dendritic Cells Both Show Extensive Surface Expression of Processed Antigen–Major Histocompatibility Complex Class II Complexes after Soluble Protein Exposure In Vivo or In Vitro

1997 • 128 citations

Invariant chain influences the immunological recognition of MHC class II molecules

1990 • 127 citations

Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41

1992 • 124 citations

Mapping functional regions in the lumenal domain of the class II-associated invariant chain.

1994 • 122 citations

A kinetic intermediate in the reaction of an antigenic peptide and I–Ek

1989 • 122 citations

Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs.

1996 • 121 citations

Supermotifs enable natural invariant chain-derived peptides to interact with many major histocompatibility complex-class II molecules.

1995 • 121 citations

The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent.

1995 • 112 citations

Resistance to herpes stromal keratitis conferred by an lgG2a-derived peptide

1995 • 111 citations

Allele-specific control of Ia molecule surface expression and conformation: implications for a general model of Ia structure-function relationships.

1987 • 107 citations

Allelic differences affecting invariant chain dependency of MHC class II subunit assembly

1995 • 106 citations

Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.

1994 • 104 citations

Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules.

1996 • 102 citations

Developing and shedding inhibitions: how MHC class II molecules reach maturity

1996 • 97 citations

Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment.

1991 • 94 citations

Cross‐blocking studies with monoclonal antibodies against I‐A molecules of haplotypes b, d and k

1982 • 81 citations

The expression of B cell surface receptors. I. The ontogeny and distribution of the murine B cell IgE Fc receptor.

1988 • 80 citations

Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP).

1996 • 77 citations

A monoclonal antibody detecting an Ia specificity mapping in the I-A or I-E subregion

1981 • 70 citations

Efficiency of antigen presentation differs in mice differing at the Mls locus

1983 • 62 citations

The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed

1998 • 62 citations

Are MHC-bound peptides a nuisance for positive selection?

1994 • 61 citations

Dendritic cell maturation and antigen presentation in the absence of invariant chain

1998 • 57 citations

B lymphocyte development and activation independent of MHC class II expression.

1993 • 57 citations

Antiviral Immune Responses of Mice Lacking MHC Class II or Its Associated Invariant Chain

1996 • 55 citations

Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains.

1991 • 52 citations

Invariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1.

1995 • 51 citations

In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DM

1997 • 51 citations

Transient Aggregation of Major Histocompatibility Complex Class II Chains during Assembly in Normal Spleen Cells

1995 • 48 citations

MHC Class II Expression in Double Mutant Mice Lacking Invariant Chain and DM Functions

1998 • 47 citations

Phenotype and function of CD4+ T cells in mice lacking invariant chain.

1996 • 44 citations

Antigen-specific, H-2-restricted helper T cell hybridomas.

1982 • 44 citations

Evidence That the Autoimmune Antigen Myelin Basic Protein (MBP) Ac1-9 Binds Towards One End of the Major Histocompatibility Complex (MHC) Cleft

1998 • 44 citations

HLA-DR polymorphism affects the interaction with CD4.

1995 • 44 citations

Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides

1998 • 42 citations

DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules.

1996 • 42 citations

Immune deficiency due to high copy numbers of an Ak beta transgene.

1990 • 38 citations

Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41 isoform of invariant chain

1995 • 36 citations

Engagement of B Cell Receptor Regulates the Invariant Chain-Dependent MHC Class II Presentation Pathway

1999 • 35 citations

Poor loading of major histocompatibility complex class II molecules with endogenously synthesized short peptides in the absence of invariant chain

1995 • 32 citations

Formation of complexes between self-peptides and MHC class II molecules in cells defective for presentation of exogenous protein antigens.

1992 • 31 citations

T Helper Subset Differentiation in the Absence of Invariant Chain

1997 • 30 citations

Presentation of igg2a antigens to class ii‐restricted t cells by stably transfected b lymphoma cells

1989 • 29 citations

Early events in the assembly of major histocompatibility complex class II heterotrimers from their free subunits

1994 • 28 citations

Functional in vivo MHC class II loading by endogenously synthesized glycoprotein during viral infection.

1997 • 28 citations

Short-lived complexes between myelin basic protein peptides and IAk.

1994 • 24 citations

Igh-1b-specific CD4+CD8− T cell clones of the Th1 subset selectively suppress the Igh-1b allotypein vivo

1991 • 23 citations

Formation and Dissociation of Short-Lived Class II MHC-Peptide Complexes

1994 • 19 citations

T and B cell receptors discriminate major histocompatibility complex class II conformations influenced by the invariant chain

1992 • 19 citations

In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain.

1997 • 17 citations

Th1 clones that suppress IgG2a^b specifically recognize an allopeptide determinant comprising residues 435–451 of γ2a^b

1993 • 17 citations

High copy number I-Ab transgenes induce production of IgE through an interluekin 4-dependent mechanism.

1996 • 15 citations

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.

1997 • 15 citations

The Ii41 isoform of invariant chain mediates both positive and negative selection events in T‐cell receptor transgenic mice

1998 • 14 citations

An immune response defect due to low levels of class II cell surface expression. Analysis of antigen presentation and positive selection.

1991 • 11 citations