Precursor RNAs Harboring Nonsense Codons Accumulate Near the Site of Transcription

A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance

1998 • 1,090 citations

Nonsense-mediated mRNA decayin health and disease

1999 • 974 citations

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

2000 • 923 citations

A Perfect Message

1999 • 807 citations

When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.

1995 • 515 citations

A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes

2001 • 480 citations

The Skipping of Constitutive Exons in Vivo Induced by Nonsense Mutations

1993 • 440 citations

Highly localized tracks of specific transcripts within interphase nuclei visualized by in situ hybridization

1989 • 434 citations

Nopp 140 shuttles on tracks between nucleolus and cytoplasm

1992 • 409 citations

Binary specification of nonsense codons by splicing and cytoplasmic translation

1998 • 396 citations

Coupled Transcription and Translation Within Nuclei of Mammalian Cells

2001 • 379 citations

Identification of a Regulated Pathway for Nuclear Pre-mRNA Turnover

2000 • 374 citations

Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.

1989 • 367 citations

The role of exon sequences in splice site selection.

1993 • 367 citations

A Regulatory Mechanism That Detects Premature Nonsense Codons in T-cell Receptor Transcripts in Vivo Is Reversed by Protein Synthesis Inhibitors in Vitro

1995 • 317 citations

Proofreading and Aminoacylation of tRNAs Before Export from the Nucleus

1998 • 316 citations

Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequences

1986 • 298 citations

Intron function in the nonsense-mediated decay of β-globin mRNA: Indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm

1998 • 297 citations

At Least One Intron Is Required for the Nonsense-Mediated Decay of Triosephosphate Isomerase mRNA: a Possible Link between Nuclear Splicing and Cytoplasmic Translation

1998 • 286 citations

A splicing-dependent regulatory mechanism that detects translation signals.

1996 • 278 citations

The Regulation of Splice-Site Selection, and Its Role in Human Disease

1997 • 277 citations

Inefficient processing impairs release of RNA from the site of transcription

1999 • 227 citations

Selenium Deficiency Reduces the Abundance of mRNA for Se-Dependent Glutathione Peroxidase 1 by a UGA-Dependent Mechanism Likely To Be Nonsense Codon-Mediated Decay of Cytoplasmic mRNA

1998 • 221 citations

Nonsense Surveillance in Lymphocytes?

1998 • 200 citations

Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.

1993 • 200 citations

A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers

1998 • 168 citations

Tracking Col1a1 RNA in Osteogenesis Imperfecta

2000 • 164 citations

The association of nonsense codons with exon skipping

1998 • 159 citations

Disruption of the splicing enhancer sequence within exon 27 of the dystrophin gene by a nonsense mutation induces partial skipping of the exon and is responsible for Becker muscular dystrophy.

1997 • 151 citations

Substrate Specificities of SR Proteins in Constitutive Splicing Are Determined by Their RNA Recognition Motifs and Composite Pre-mRNA Exonic Elements

1999 • 146 citations

Maintenance of an open reading frame as an additional level of scrutiny during splice site selection

1994 • 146 citations

Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

1994 • 140 citations

Pem:A Testosterone- and LH-Regulated Homeobox Gene Expressed in Mouse Sertoli Cells and Epididymis

1996 • 137 citations

A splicing enhancer exhibits both constitutive and regulated activities.

1994 • 136 citations

Nonsense Mutations Inhibit RNA Splicing in a Cell-Free System: Recognition of Mutant Codon Is Independent of Protein Synthesis

1996 • 132 citations

Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping.

1994 • 131 citations

Nuclear Eukaryotic Initiation Factor 4e (Eif4e) Colocalizes with Splicing Factors in Speckles

2000 • 130 citations

Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.

1992 • 124 citations

Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells.

1983 • 121 citations

The Nucleolus and the Four Ribonucleoproteins of Translation

2000 • 121 citations

Nonsense Codons in Human β-Globin mRNA Result in the Production of mRNA Degradation Products

1992 • 118 citations

Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing.

1994 • 97 citations

Activation of RNA polymerase III transcription of human Alu repetitive elements by adenovirus type 5: requirement for the E1b 58-kilodalton protein and the products of E4 open reading frames 3 and 6.

1993 • 93 citations

Transfer of a cloned immunoglobulin light-chain gene to mutant hybridoma cells restores specific antibody production

1983 • 78 citations

T Cell Receptor (TCR) Mini-Gene mRNA Expression Regulated by Nonsense Codons: A Nuclear-associated Translation-like Mechanism

1997 • 76 citations

Effects of Nonsense Mutations on Nuclear and Cytoplasmic Adenine Phosphoribosyltransferase RNA

1996 • 66 citations

Differential regulation of endogenous and transduced beta-globin genes during infection of erythroid cells with a herpes simplex virus type 1 recombinant

1990 • 65 citations

Review: Movement of mRNA from Transcription Site to Nuclear Pores

2000 • 59 citations

Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products.

1992 • 58 citations

Nonsense mutations in the alcohol dehydrogenase gene of Drosophila melanogaster correlate with an abnormal 3′ end processing of the corresponding pre-mRNA

1999 • 49 citations

RNAs radiate from gene to cytoplasm as revealed by fluorescence in situ hybridization

1995 • 45 citations

New Species of Human Tyrosine Hydroxylase mRNA Are Produced in Variable Amounts in Adrenal Medulla and Are Overexpressed in Progressive Supranuclear Palsy

1996 • 41 citations

Monoclonal antibody-aided characterization of cellular p220 in uninfected and poliovirus-infected HeLa cells: subcellular distribution and identification of conformers

1987 • 39 citations

On the linkage between RNA processing and RNA translatability.

1994 • 38 citations

Highly localized tracks of human immunodeficiency virus type 1 Nef in the nucleus of cells of a human CD4+ T-cell line.

1993 • 38 citations

Frameshift Mutations in the v-src Gene of Avian Sarcoma Virus Act in cis To Specifically Reduce v-src mRNA Levels

1994 • 36 citations

A Premature Termination Codon in Either Exon of Minute Virus of Mice P4 Promoter-generated Pre-mRNA Can Inhibit Nuclear Splicing of the Intervening Intron in an Open Reading Frame-dependent Manner

1999 • 35 citations

A Premature Termination Codon Interferes with the Nuclear Function of an Exon Splicing Enhancer in an Open Reading Frame-Dependent Manner

1999 • 33 citations

Infrequent Translation of a Nonsense Codon Is Sufficient to Decrease mRNA Level

1999 • 30 citations

The association of nonsense mutation with exon-skipping in hprt mRNA of Chinese hamster ovary cells results from an artifact of RT-PCR.

1997 • 24 citations

Nonsense-Mediated mRNA Decay in Xenopus Oocytes and Embryos

1994 • 23 citations

Coupling of Transcription and Translation in Dictyostelium discoideum Nuclei

1999 • 18 citations

Frameshift mutations in the v-src gene of avian sarcoma virus act in cis to specifically reduce v-src mRNA levels.

1994 • 14 citations

Isolation of new nonsense and frameshift mutants in the immunoglobulin ? heavy-chain gene of hybridoma cells

1993 • 14 citations

Contribution of Growing RNA Molecules to the Nuclear Transcripts Foci Observed by FISH

1998 • 12 citations