Nonsense Surveillance in Lymphocytes?

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS

1996 • 653 citations

A survey on intron and exon lengths

1988 • 569 citations

When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.

1995 • 515 citations

mRNA surveillance by the Caenorhabditis elegans smg genes.

1993 • 459 citations

The Skipping of Constitutive Exons in Vivo Induced by Nonsense Mutations

1993 • 440 citations

Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.

1989 • 367 citations

A Regulatory Mechanism That Detects Premature Nonsense Codons in T-cell Receptor Transcripts in Vivo Is Reversed by Protein Synthesis Inhibitors in Vitro

1995 • 317 citations

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.

1995 • 278 citations

A splicing-dependent regulatory mechanism that detects translation signals.

1996 • 278 citations

Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.

1993 • 265 citations

Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.

1993 • 200 citations

Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse.

1985 • 193 citations

Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

1993 • 179 citations

Pre-mRNA Processing and the CTD of RNA Polymerase II: The Tail That Wags the Dog?

1997 • 165 citations

Nonsense codon mutations in the terminal exon of the beta-globin gene are not associated with a reduction in beta-mRNA accumulation: a mechanism for the phenotype of dominant beta-thalassemia

1994 • 164 citations

Maintenance of an open reading frame as an additional level of scrutiny during splice site selection

1994 • 146 citations

Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

1994 • 140 citations

Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product.

1992 • 135 citations

Nonsense Mutations Inhibit RNA Splicing in a Cell-Free System: Recognition of Mutant Codon Is Independent of Protein Synthesis

1996 • 132 citations

Introns are cis Effectors of the Nonsense-Codon-Mediated Reduction in Nuclear mRNA Abundance

1994 • 131 citations

Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping.

1994 • 131 citations

Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.

1992 • 124 citations

Relationship between Yeast Polyribosomes and Upf Proteins Required for Nonsense mRNA Decay

1997 • 114 citations

Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

1995 • 113 citations

Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing.

1994 • 97 citations

Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA.

1993 • 97 citations

Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance.

1994 • 96 citations

Inhibition of nonsense-mediated messenger RNA decay in clinical samples facilitates detection of human MSH2 mutations with an in vivo fusion protein assay and conventional techniques.

1997 • 84 citations

Spatial consequences of defective processing of specific yeast mRNAs revealed by fluorescent in situ hybridization.

1995 • 82 citations

T Cell Receptor (TCR) Mini-Gene mRNA Expression Regulated by Nonsense Codons: A Nuclear-associated Translation-like Mechanism

1997 • 76 citations

Nuclear degradation of nonsense mutated β-globin mRNA: a post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of β-thalassemia?

1995 • 73 citations

Effects of Nonsense Mutations on Nuclear and Cytoplasmic Adenine Phosphoribosyltransferase RNA

1996 • 66 citations

Determination of mRNA fate by different RNA polymerase II promoters.

1993 • 66 citations

Endoplasmicreticulum-induced signal transduction and gene expression

1997 • 64 citations

New proteins related to the Ser-Arg family of splicing factors.

1995 • 54 citations

Translation affects immunoglobulin mRNA stability

1989 • 52 citations

T Cell Receptor-β mRNA Splicing: Regulation of Unusual Splicing Intermediates

1993 • 46 citations

Evidence that the decay of nucleus-associated nonsense mRNA for human triosephosphate isomerase involves nonsense codon recognition after splicing.

1996 • 45 citations

On the linkage between RNA processing and RNA translatability.

1994 • 38 citations

Frameshift Mutations in the v-src Gene of Avian Sarcoma Virus Act in cis To Specifically Reduce v-src mRNA Levels

1994 • 36 citations

Evidence for degradation of mRNA encoding alpha-L-iduronidase in Hurler fibroblasts with premature termination alleles.

1994 • 35 citations

T cell receptor-beta mRNA splicing during thymic maturation in vivo and in an inducible T cell clone in vitro.

1993 • 28 citations

T cell receptor-beta mRNA splicing: regulation of unusual splicing intermediates.

1993 • 15 citations

Frameshift mutations in the v-src gene of avian sarcoma virus act in cis to specifically reduce v-src mRNA levels.

1994 • 14 citations