RNA surveillance: unforeseen consequences for gene expression, inherited genetic disorders and cancer

Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G.

1996 • 679 citations

Termination of translation in eukaryotes is governed by two interacting polypeptide chain release factors, eRF1 and eRF3.

1995 • 589 citations

The ribosome: Structure, function and evolution

1991 • 531 citations

When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.

1995 • 515 citations

FMRP Associates with Polyribosomes as an mRNP, and the I304N Mutation of Severe Fragile X Syndrome Abolishes This Association

1997 • 509 citations

The Ribosome : structure, function, and evolution

1990 • 508 citations

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.

1991 • 487 citations

mRNA surveillance by the Caenorhabditis elegans smg genes.

1993 • 459 citations

Interference of nonsense mutations with eukaryotic messenger RNA stability.

1979 • 454 citations

The Skipping of Constitutive Exons in Vivo Induced by Nonsense Mutations

1993 • 440 citations

Premature translational termination triggers mRNA decapping

1994 • 399 citations

Control of Messenger RNA Stability

1993 • 394 citations

The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

1998 • 341 citations

Gene products that promote mRNA turnover in Saccharomyces cerevisiae.

1992 • 330 citations

An essential component of the decapping enzyme required for normal rates of mRNA turnover

1996 • 328 citations

mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor.

1993 • 307 citations

The Efficiency of Translation Termination is Determined by a Synergistic Interplay Between Upstream and Downstream Sequences inSaccharomyces cerevisiae

1995 • 303 citations

Predominance of null mutations in ataxia-telangiectasia

1996 • 293 citations

Mutations and Polymorphisms in the familial early-onset breast cancer (BRCA1) gene

1996 • 288 citations

Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.

1995 • 279 citations

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.

1995 • 278 citations

A new kind of informational suppression in the nematode Caenorhabditis elegans.

1989 • 272 citations

Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.

1993 • 265 citations

Translational Control

2001 • 248 citations

Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae

1996 • 246 citations

Upf1p, Nmd2p, and Upf3p Are Interacting Components of the Yeast Nonsense-Mediated mRNA Decay Pathway

1997 • 229 citations

eIF4G--A Multipurpose Ribosome Adapter?

1997 • 223 citations

Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast

1995 • 223 citations

Genetic and Biochemical Characterization of Mutations in the ATPase and Helicase Regions of the Upf1 Protein

1996 • 214 citations

Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells

1997 • 185 citations

Purification and characterization of the Upf1 protein: a factor involved in translation and mRNA degradation.

1995 • 184 citations

A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsensecontaining mRNAs in mammalian cells

1998 • 181 citations

Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

1993 • 179 citations

Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme

1998 • 160 citations

Identification and Characterization of Mutations in the UPF1 Gene That Affect Nonsense Suppression and the Formation of the Upf Protein Complex but Not mRNA Turnover

1996 • 152 citations

A Look at Messenger RNP Moving through the Nuclear Pore

1997 • 149 citations

Maintenance of an open reading frame as an additional level of scrutiny during splice site selection

1994 • 146 citations

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein

1997 • 144 citations

The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm.

1995 • 132 citations

Mammalian orthologues of a yeast regulator of nonsense transcript stability.

1996 • 129 citations

Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.

1992 • 124 citations

SUF12 suppressor protein of yeast

1988 • 118 citations

Premature nonsense codons decrease the stability of phytohemagglutinin mRNA in a position‐dependent manner

1996 • 115 citations

Relationship between Yeast Polyribosomes and Upf Proteins Required for Nonsense mRNA Decay

1997 • 114 citations

Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

1995 • 113 citations

FRAMESHIFT SUPPRESSION IN SACCHAROMYCES CEREVISIAE. II. GENETIC PROPERTIES OF GROUP II SUPPRESSORS

1980 • 97 citations

NAM7 nuclear gene encodes a novel member of a family of helicases with a Zn-ligand motif and is involved in mitochondrial functions in Saccharomyces cerevisiae

1992 • 91 citations

Telomere Length Regulation and Telomeric Chromatin Require the Nonsense-Mediated mRNA Decay Pathway

1998 • 78 citations

mRNA surveillance mitigates genetic dominance in Caenorhabditis elegans

1998 • 66 citations

Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast.

1996 • 66 citations

Isolation of the SUP45 omnipotent suppressor gene of Saccharomyces cerevisiae and characterization of its gene product.

1985 • 65 citations

Context Effects on Misreading and Suppression at UAG Codons in Human Cells

1995 • 63 citations

A factor required for nonsense-mediated mRNA decay in yeast is exported from the nucleus to the cytoplasm by a nuclear export signal sequence

1998 • 61 citations

Mutations to nonsense codons in human genetic disease: implications for gene therapy by nonsense suppressor tRNAs

1994 • 57 citations

mRNA Turnover in Saccharomyces cerevisiae

1993 • 52 citations

Suppressible Four-Base Glycine and Proline Codons in Yeast

1981 • 49 citations

The end in sight: terminating translation in eukaryotes

1995 • 33 citations

Frameshift suppressor mutations affecting the major glycine transfer RNAs of Saccharomyces cerevisiae

1987 • 32 citations

Accumulation of mRNA Coding for the Ctf13p Kinetochore Subunit of Saccharomyces cerevisiae Depends on the Same Factors That Promote Rapid Decay of Nonsense mRNAs

1998 • 29 citations