Coupling transcription to translation: A novel site for the regulation of eukaryotic gene expression

The scanning model for translation: an update.

1989 • 3,525 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Gene Activity in Early Development

1968 • 1,725 citations

hnRNP PROTEINS AND THE BIOGENESIS OF mRNA

1993 • 1,486 citations

Capping of eucaryotic mRNAs

1976 • 1,141 citations

Chromatin Structure and Function

1979 • 1,050 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Molecular Biology of the Cell

1990 • 951 citations

Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

1992 • 825 citations

The sequence 5′-AAUAAA-3′ forms part of the recognition site for polyadenylation of late SV40 mRNAs

1981 • 819 citations

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

1990 • 723 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

Visualization of focal sites of transcription within human nuclei.

1993 • 656 citations

Tat trans-activates the human immunodeficiency virus through a nascent RNA target

1989 • 644 citations

Do the poly(A) tail and 3′ untranslated region control mRNA translation?

1990 • 618 citations

Experimental Approaches to Mammalian Embryonic Development

1987 • 596 citations

Recognition of cap structure in splicing in vitro of mRNA precursors

1984 • 575 citations

Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus

1993 • 541 citations

A specific transcription factor that can bind either the 5S RNA gene or 5S RNA.

1980 • 511 citations

A nuclear cap binding protein complex involved in pre-mRNA splicing

1994 • 506 citations

5'-terminal cap structure in eucaryotic messenger ribonucleic acids

1980 • 463 citations

Processing of RNA

1976 • 462 citations

mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence.

1986 • 455 citations

Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.

1988 • 432 citations

Monomethylated cap structures facilitate RNA export from the nucleus

1990 • 411 citations

Nopp 140 shuttles on tracks between nucleolus and cytoplasm

1992 • 409 citations

Purified lupus antigen la recognizes an oligouridylate stretch common to the 3′ termini of RNA polymerase III transcripts

1984 • 382 citations

Structural and functional properties of the evolutionarily ancient Y‐box family of nucleic acid binding proteins

1994 • 367 citations

A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps.

1993 • 352 citations

Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III.

1989 • 340 citations

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.

1991 • 338 citations

A Three-Dimensional View of Precursor Messenger RNA Metabolism Within the Mammalian Nucleus

1993 • 335 citations

A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein.

1993 • 327 citations

Nuclear export of different classes of RNA is mediated by specific factors

1994 • 323 citations

RNA on the move: the mRNA localization pathway [published erratum appears in J Cell Biol 1993 Dec;123(6 Pt 1):1625]

1993 • 315 citations

A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif.

1994 • 315 citations

Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription

1994 • 277 citations

In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism

1993 • 272 citations

Characterization of cDNAs encoding the polypyrimidine tract-binding protein.

1991 • 257 citations

Translocation of a specific premessenger ribonucleoprotein particle through the nuclear pore studied with electron microscope tomography

1992 • 254 citations

Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA.

1994 • 248 citations

Structure and Function of Nuclear and Cytoplasmic Ribonucleoprotein Particles

1986 • 243 citations

Gene Activity in Early Development

1988 • 237 citations

The Y-box factors: a family of nucleic acid binding proteins conserved from Escherichia coli to man.

1992 • 232 citations

Physical isolation of nascent RNA chains transcribed by RNA polymerase II: evidence for cotranscriptional splicing.

1994 • 230 citations

Chapter 1 On “Masked” Forms of Messenger Rna in Early Embryogenesis and in Other Differentiating Systems

1966 • 221 citations

Specific binding of heterogeneous ribonucleoprotein particle protein K to the human c-myc promoter, in vitro.

1993 • 220 citations

Protein components specifically associated with prespliceosome and spliceosome complexes.

1992 • 218 citations

Sequence analysis of cytoplasmic mRNA-binding proteins of Xenopus oocytes identifies a family of RNA-binding proteins.

1992 • 204 citations

The RNA binding protein La influences both the accuracy and the efficiency of RNA polymerase III transcription in vitro.

1989 • 202 citations

A role for transcription and FRGY2 in masking maternal mRNA within Xenopus oocytes

1994 • 198 citations

Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif

1987 • 187 citations

Trans splicing of mrna precursors in vitro

1985 • 180 citations

Chromatin structure and function

1994 • 180 citations

A mutational analysis of spliceosome assembly: evidence for splice site collaboration during spliceosome formation.

1987 • 179 citations

The Major Protein of Messenger Ribonucleoprotein Particles in Somatic Cells Is a Member of the Y-box Binding Transcription Factor Family

1995 • 175 citations

Transcription Units for mRNA Production in Eukaryotic Cells and Their DNA Viruses

1979 • 173 citations

Does HIV-1 Tat induce a change in viral initiation rights?

1993 • 166 citations

Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA.

1990 • 159 citations

Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III.

1994 • 157 citations

Cap-dependent RNA splicing in a HeLa nuclear extract.

1985 • 156 citations

hnRNP proteins:Localization and transport between the nucleus and the cytoplasm

1993 • 150 citations

N-6-methyl-adenosine in adenovirus type 2 nuclear RNA is conserved in the formation of messenger RNA

1979 • 139 citations

Reversible inhibition of translation by Xenopus oocyte-specific proteins

1984 • 139 citations

Masking mRNA from translation in somatic cells.

1993 • 138 citations

HIV-1 TAT “activates” presynthesized RNA in the nucleus

1989 • 135 citations

The Transcriptional Regulatory Protein, YB-1, Promotes Single-stranded Regions in the DRA Promoter

1995 • 134 citations

Kinetics of formation of 5′ terminal caps in mRNA

1976 • 134 citations

A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif

1992 • 133 citations

A mouse Y box protein, MSY1, is associated with paternal mRNA in spermatocytes

1993 • 128 citations

Export of mRNA from microinjected nuclei of Xenopus laevis oocytes.

1992 • 121 citations

Selective recruitment of masked maternal mRNA from messenger ribonucleoprotein particles containing FRGY2 (mRNP4).

1993 • 121 citations

Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation.

1987 • 115 citations

Protein composition of mammalian spliceosomes assembled in vitro.

1990 • 112 citations

The HIV-1 Rev protein: prototype of a novel class of eukaryotic post-transcriptional regulators

1991 • 106 citations

Functions of the 5′‐terminal m⁷G cap in eukaryotic mRNA

1978 • 99 citations

Role of cytoplasmic mRNP proteins in translation

1992 • 97 citations

Expression of the poly(A)-binding protein during development of Xenopus laevis.

1989 • 94 citations

Intron-less RNA injected into the nucleus of Xenopus oocytes accesses a regulated translation control pathway

1994 • 90 citations

mRNP4, a major mRNA-binding protein from Xenopus oocytes is identical to transcription factor FRG Y2.

1992 • 88 citations

Phosphorylatlon of a 60 kDa polypeptide fromXenopusoocytes blocks messenger RNA translation

1987 • 87 citations

A nuclear translational block imposed by the HIV-1 U3 region is relieved by the Tat-TAR interaction

1990 • 86 citations

Purification and characterization of the major 50‐kDa repressor protein from cytoplasmic mRNP of rabbit reticulocytes

1993 • 85 citations

Spliceosomes and Snurposomes

1991 • 85 citations

Nuclear RNA is spliced in the absence of poly(A) addition

1981 • 84 citations

DNA binding, multimerization, and transcription stimulation by the Xenopus Y box proteins in vitro.

1992 • 80 citations

Cloning and sequencing of PYBP, a pyrimidine-rich specific single strand DNA-binding protein

1991 • 69 citations

Nuclear mRNA export

1991 • 69 citations

Histone H4 acetylation and transcription in amphibian chromatin.

1993 • 61 citations

Chapter 9 Preparation of Synthetic mRNAs and Analyses of Translational Efficiency in Microinjected Xenopus Oocytes

1991 • 61 citations

Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression

1994 • 60 citations

Transcription of a human neurotropic virus promoter in glial cells: effect of YB-1 on expression of the JC virus late gene

1994 • 57 citations

Blocking of Tat-dependent HIV-1 RNA modification by an inhibitor of RNA polymerase II processivity

1991 • 55 citations

Regulation of gene expression during mammalian spermatogenesis

1987 • 54 citations

The role of the nucleolus in the transfer of RNA from nucleus to cytoplasm

1969 • 53 citations

Nucleic Acid-Binding Properties of the Xenopus Oocyte Y Box Protein mRNP3+4

1994 • 52 citations

T Cell Receptor-β mRNA Splicing: Regulation of Unusual Splicing Intermediates

1993 • 46 citations

The rat poly Pyrimidine Tract binding protein (PTB) interacts with a single-stranded DNA motif in a liver-specific enhancer

1992 • 44 citations

Enhancement of mRNA nuclear transport by promoter elements

1987 • 44 citations

Identification of a 60‐kDa phosphoprotein that binds stored messenger RNA of Xenopus oocytes

1985 • 42 citations

The Balbiani ring particle: a model for the assembly and export of RNPs from the nucleus?

1993 • 39 citations

Purification of two thermostable components of messenger ribonucleoprotein particles (mRNPs) from Xenopus laevis oocytes, belonging to a novel class of RNA‐binding proteins

1991 • 30 citations

T cell receptor-beta mRNA splicing during thymic maturation in vivo and in an inducible T cell clone in vitro.

1993 • 28 citations

RNA-binding phosphoproteins and the regulation of maternal mRNA in Xenopus.

1990 • 26 citations

Promoter control of translation inXenopus oocytes

1995 • 21 citations

T cell receptor-beta mRNA splicing: regulation of unusual splicing intermediates.

1993 • 15 citations