Fitness of Human Immunodeficiency Virus Type 1 Protease Inhibitor-Selected Single Mutants

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1986 • 2,918 citations

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

1995 • 984 citations

Human Immunodeficiency Virus Reverse Transcriptase and Protease Sequence Database

1999 • 934 citations

Ordered accumulation of mutations in HIV protease confers resistance to ritonavir

1996 • 776 citations

Antiretroviral Drug Resistance Testing in Adults With HIV Infection

1998 • 582 citations

Extensive polymorphisms observed in HIV–1 clade B protease gene using high–density oligonucleotide arrays

1996 • 545 citations

HIV-1 Drug Resistance in Newly Infected Individuals

1999 • 484 citations

Sexual Transmission of an HIV-1 Variant Resistant to Multiple Reverse-Transcriptase and Protease Inhibitors

1998 • 458 citations

Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor

1996 • 411 citations

Transmission of antiretroviral-drug-resistant HIV-1 variants

1999 • 401 citations

Replicative Fitness of Protease Inhibitor-Resistant Mutants of Human Immunodeficiency Virus Type 1

1999 • 400 citations

A Rapid Method for Simultaneous Detection of Phenotypic Resistance to Inhibitors of Protease and Reverse Transcriptase in Recombinant Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Antiretroviral Drugs

1998 • 395 citations

Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy

1999 • 372 citations

Reduced Antiretroviral Drug Susceptibility Among Patients With Primary HIV Infection

1999 • 348 citations

Introduction to Theoretical Population Genetics

1992 • 332 citations

Quantitation of relative fitness and great adaptability of clonal populations of RNA viruses

1991 • 278 citations

Kinetic Characterization and Cross-Resistance Patterns Of HIV-1 Protease Mutants Selected under Drug Pressure

1995 • 264 citations

Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor

1995 • 226 citations

Antiviral drug resistance

2006 • 222 citations

Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor

1994 • 217 citations

Genotypic and Phenotypic Characterization of Human Immunodeficiency Virus Type 1 Variants Isolated from Patients Treated with the Protease Inhibitor Nelfinavir

1998 • 204 citations

Cross-resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors

1995 • 185 citations

In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 1 Variants with Increased Resistance to ABT-378, a Novel Protease Inhibitor

1998 • 169 citations

In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects

1996 • 149 citations

Comparative Fitness of Multi-Dideoxynucleoside-Resistant Human Immunodeficiency Virus Type 1 (HIV-1) in an In Vitro Competitive HIV-1 Replication Assay

1999 • 127 citations

Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication

1996 • 94 citations

Kinetic Characterization of Human Immunodeficiency Virus Type-1 Protease-resistant Variants

1996 • 79 citations

Sequence requirements of the HIV-1 protease flap region determined by saturation mutagenesis and kinetic analysis of flap mutants

1997 • 69 citations

Resistance and cross-resistance with saquinavir and other HIV protease inhibitors

1998 • 65 citations

Introduction to theoretical population genetics

1993 • 58 citations

Antiviral Drug Resistance

1997 • 46 citations

Phenotypic Changes in Drug Susceptibility Associated with Failure of Human Immunodeficiency Virus Type 1 (HIV‐1) Triple Combination Therapy

1999 • 46 citations

Human Immunodeficiency Virus Type 1 Cloning Vectors for Antiretroviral Resistance Testing

1999 • 39 citations

Once versus twice daily administration of didanosine in children with symptomatic HIV-associated disease who were intolerant to or clinically deteriorated on zidovudine. The Italian Pediatric Collaborative Study Group on Didanosine.

1997 • 4 citations