The Differential Ability of HLA B^*5701⁺Long-Term Nonprogressors and Progressors To Restrict Human Immunodeficiency Virus Replication Is Not Caused by Loss of Recognition of Autologous ViralgagSequences

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

1994 • 2,529 citations

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 ⁺ Lymphocytes

1999 • 2,206 citations

Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

1999 • 1,428 citations

Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

1997 • 1,206 citations

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

1997 • 1,135 citations

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

1991 • 1,025 citations

HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

2000 • 990 citations

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

2002 • 986 citations

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

2000 • 879 citations

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

1997 • 696 citations

Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia

2000 • 693 citations

Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4 ⁺ and CD8 ⁺ T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection

2001 • 693 citations

Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes

2002 • 670 citations

Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.

1995 • 650 citations

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

1990 • 558 citations

Evolution and transmission of stable CTL escape mutations in HIV infection

2001 • 549 citations

Administration of an Anti-CD8 Monoclonal Antibody Interferes with the Clearance of Chimeric Simian/Human Immunodeficiency Virus during Primary Infections of Rhesus Macaques

1998 • 502 citations

Clustered Mutations in HIV-1 Gag Are Consistently Required for Escape from Hla-B27–Restricted Cytotoxic T Lymphocyte Responses

2001 • 459 citations

HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides

1988 • 447 citations

Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef

1999 • 387 citations

Antigenic oscillations and shifting immunodominance in HIV-1 infections

1995 • 325 citations

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein

1991 • 303 citations

Impaired function of circulating HIV-specific CD8+ T cells in chronic human immunodeficiency virus infection

2000 • 273 citations

Maintenance of Large Numbers of Virus-Specific CD8+ T Cells in HIV-Infected Progressors and Long-Term Nonprogressors

2000 • 271 citations

Substantial Differences in Specificity of HIV-Specific Cytotoxic T Cells in Acute and Chronic HIV Infection

2001 • 261 citations

Novel, Cross-Restricted, Conserved, and Immunodominant Cytotoxic T Lymphocyte Epitopes in Slow Progressors in HIV Type 1 Infection

1996 • 241 citations

Clade B-based HIV-1 vaccines elicit cross-clade cytotoxic T lymphocyte reactivities in uninfected volunteers

1997 • 234 citations

A recombinant vaccinia virus based ELISPOT assay detects high frequencies of Pol-specific CD8 T cells in HIV-1-positive individuals

1999 • 217 citations

High-level HIV-1 viremia suppresses viral antigen-specific CD4⁺T cell proliferation

2001 • 215 citations

A Novel Approach to the Analysis of Specificity, Clonality, and Frequency of HIV-Specific T Cell Responses Reveals a Potential Mechanism for Control of Viral Escape

2002 • 203 citations

A Significant Number of Human Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes Detected by Tetramer Binding Do Not Produce Gamma Interferon

2000 • 201 citations

Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.

1996 • 189 citations

Persistent numbers of tetramer+ CD8+ T cells, but loss of interferon-γ+ HIV-specific T cells during progression to AIDS

2002 • 186 citations

Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes.

1992 • 184 citations

Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein.

1994 • 175 citations

Putative Immunodominant Human Immunodeficiency Virus-Specific CD8⁺T-Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype

2000 • 156 citations

Broad, Intense Anti-Human Immunodeficiency Virus (HIV) Ex Vivo CD8⁺Responses in HIV Type 1-Infected Patients: Comparison with Anti-Epstein-Barr Virus Responses and Changes during Antiretroviral Therapy

1999 • 146 citations

Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes

1995 • 121 citations

Cross-reactive cytotoxic T lymphocytes against a HIV-1 p24 epitope in slow progressors with B*57

2002 • 119 citations

Human Immunodeficiency Virus Type 1 Quasi Species That Rebound after Discontinuation of Highly Active Antiretroviral Therapy Are Similar to the Viral Quasi Species Present before Initiation of Therapy

2001 • 117 citations

Preparation of Cells and Reagents for Flow Cytometry

2001 • 108 citations

Impaired function of circulating HIV-specific CD8+ T cells in chronic human immunodeficiency virus infection

2000 • 103 citations

Polymorphism in the alpha 1 helix of the HLA-B heavy chain can have an overriding influence on peptide-binding specificity.

1997 • 91 citations

Immunobiology of cytotoxic T-cell escape mutants of lymphocytic choriomeningitis virus

1995 • 91 citations

In vivo persistence of a HIV‐1‐encoded HLA‐B27‐restricted cytotoxic T lymphocyte epitope despite specific in vitro reactivity

1991 • 78 citations

Frequency and function of HIV-specific CD8+ T Cells

2001 • 75 citations

Simian Immunodeficiency Virus Evades a Dominant Epitope-Specific Cytotoxic T Lymphocyte Response Through a Mutation Resulting in the Accelerated Dissociation of Viral Peptide and MHC Class I

2000 • 75 citations

CXCR4 and CCR5 Genetic Polymorphisms in Long-Term Nonprogressive Human Immunodeficiency Virus Infection: Lack of Association with Mutations other than CCR5-Δ32

1998 • 66 citations

Uncovering subdominant cytotoxic T-lymphocyte responses in lymphocytic choriomeningitis virus-infected BALB/c mice

1997 • 58 citations

In Vivo Selection of a Lymphocytic Choriomeningitis Virus Variant That Affects Recognition of the GP33-43 Epitope by H-2D^bbut Not H-2K^b

2001 • 53 citations

Functional restoration of human immunodeficiency virus and Epstein-Barr virus-specific CD8+ T cells during highly active antiretroviral therapy is associated with an increase in CD4+ T cells

2002 • 46 citations

Emergence of virus escape mutants after immunization with epitope vaccine

1995 • 40 citations

The functional CD8 T cell response to HIV becomes type-specific in progressive disease

2002 • 30 citations

Use of vaccinia virus vectors to study the synthesis, intracellular localization, and action of the human immunodeficiency virus trans-activator protein

1988 • 25 citations

The functional CD8 T cell response to HIV becomes type-specific in progressive disease

2002 • 25 citations