Toxicology of Quinone-Thioethers

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Naturally Occurring Quinones

1971 • 1,283 citations

Bioactivation of foreign compounds

1985 • 733 citations

The Kidney: Physiology and Pathophysiology.

1985 • 665 citations

Encyclopedia of Chemical Technology

1953 • 628 citations

A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERS

1954 • 591 citations

Alcohol, Amines, and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction

1970 • 558 citations

[56] DT diaphorase

1967 • 521 citations

Sampling of vehicle emissions for chemical analysis and biological testing.

1983 • 457 citations

Alkaloids from Catecholamines in Adrenal Tissue: Possible Role in Alcoholism

1970 • 441 citations

Biochemical Assessment of Serotonergic and Cholinergic Dysfunction and Cerebral Atrophy in Alzheimer's Disease

1983 • 440 citations

γ-Glutamyl Transpeptidase in Isolated Brain Endothelial Cells: Induction by Glial Cells in Vitro

1980 • 404 citations

The Identification of Polynuclear Aromatic Hydrocarbon (PAH) Derivatives in Mutagenic Fractions of Diesel Particulate Extracts

1981 • 404 citations

Mutagenicity of quinones: pathways of metabolic activation and detoxification.

1984 • 384 citations

Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase.

1981 • 314 citations

Glutathione S-transferases and drug resistance

1991 • 299 citations

Methemoglobinemia: A Comprehensive Treatise

2019 • 285 citations

Bioenergetics Bulletin Prospers

1970 • 281 citations

A Method for Determination of Low Carbon Monoxide Concentration in Blood

1966 • 269 citations

γ-Glutamyl Transpeptidase in Brain Capillaries: Possible Site of a Blood-Brain Barrier for Amino Acids

1974 • 269 citations

The search for a solution to senile cataracts. Proctor lecture.

1984 • 268 citations

Glutathione conjugation: Mechanisms and biological significance

1989 • 267 citations

Caftaric Acid Disappearance and Conversion to Products of Enzymic Oxidation in Grape Must and Wine

1985 • 262 citations

Decreased Imipramine Binding in the Brains of Patients with Depressive Illness

1983 • 253 citations

Long-lasting selective depletion of brain serotonin by 5,6-dihydroxytryptamine.

1971 • 241 citations

Mechanisms of Cataract Formation in the Human Lens

1981 • 239 citations

Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects

1988 • 220 citations

Presynaptic Serotonergic Dysfunction in Patients with Alzheimer's Disease

1987 • 213 citations

n-Electrode three-dimensional liquid chromatography with electrochemical detection for determination of neurotransmitters.

1984 • 203 citations

Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct.

1990 • 195 citations

Biosynthesis and biotransformation of glutathioneS-Conjugates to toxic metabolites

1988 • 193 citations

Tryptamine receptors

1953 • 186 citations

Alcohol Drinking: Abnormal Intake Caused by Tetrahydropapaveroline in Brain

1977 • 183 citations

Hepatic low-level chemiluminescence during redox cycling of menadione and the menadione-glutathione conjugate: Relation to glutathione and NAD(P)H:quinone reductase (DT-diaphorase) activity

1983 • 180 citations

The Metabolism of Serotonin (5-Hydroxytryptamine)

1959 • 171 citations

DT-diaphorase-catalysed reduction of 1,4-naphthoquinone derivatives and glutathionyl-quinone conjugates. Effect of substituents on autoxidation rates

1989 • 170 citations

Sequential oxidation and glutathione addition to 1,4-benzoquinone: correlation of toxicity with increased glutathione substitution.

1988 • 165 citations

Reduced and oxidized glutathione in human and monkey brain

1987 • 164 citations

EFFECTS OF 5,6‐DIHYDROXYTRYPTAMINE ON MONOAMINERGIC NEURONES IN THE CENTRAL NERVOUS SYSTEM OF THE RAT

1972 • 163 citations

Dopamine-Related Tetrahydroisoquinolines: Significant Urinary Excretion by Alcoholics After Alcohol Consumption

1979 • 157 citations

Cysteine conjugate beta-lyase in rat liver. A novel enzyme catalyzing formation of thiol-containing metabolites of drugs.

1978 • 155 citations

Bioactivation of Nephrotoxic Haloalkenes by Glutathione Conjugation: Formation of Toxic and Mutagenic Intermediates by Cysteine Conjugate β-Lyase

1989 • 151 citations

Studies in detoxication. 49. The metabolism of benzene containing [14C1]benzene

1953 • 151 citations

Relative carcinogenic activity of various synthetic and natural estrogens in the Syrian hamster kidney.

1983 • 141 citations

Ultrastructural pathology of human renal cell tumors.

1971 • 140 citations

Studies on Quinone-Thioethers. I. Mechanism of Formation and Properties of Thiodione^*

1963 • 130 citations

Glutathione conjugates of 2-bromohydroquinone are nephrotoxic.

1985 • 126 citations

Multi-step metabolic activation of benzene. Effect of superoxide dismutase on covalent binding to microsomal macromolecules, and identification of glutathione conjugates using high pressure liquid chromatography and field desorption mass spectrometry

1980 • 121 citations

Nephrotoxicity of p-aminophenol, a metabolite of acetaminophen, in the Fischer 344 rat

1982 • 121 citations

Quinone-Induced Oxidative Injury to Cells and Tissues

1985 • 109 citations

Metabolism of Xenobiotics

2016 • 107 citations

Studies on the Mechanism of Nephrotoxicity and Nephrocarcinogenicity of Halogenated Alkenes

1988 • 104 citations

Light- and GTP-activated hydrolysis of phosphatidylinositol bisphosphate in squid photoreceptor membranes.

1988 • 101 citations

The Reaction of Thiol Compounds with Quinones

1939 • 101 citations

Biotransformation of phenol to hydroquinone and catechol by rat liver microsomes.

1983 • 99 citations

Formation of glutathione-conjugated semiquinones by the reaction of quinones with glutathione: An ESR study

1987 • 98 citations

The addition and substitution chemistry of quinones

2010 • 97 citations

Biochemical characterisation of para-aminophenol-induced nephrotoxic lesions in the F344 rat

1989 • 97 citations

p-Aminophenol nephrotoxicity: Biosynthesis of toxic glutathione conjugates

1992 • 96 citations

Metabolism and mechanism of action of oestrogens XII. Structure and mechanism of formation of water-soluble and protein-bound metabolites of oestrone in rat-liver microsomes in vitro and in vivo

1969 • 94 citations

Isolation of two proteins with 9-ketoprostaglandin reductase and NADP-linked 15-hydroxyprostaglandin dehydrogenase activities and studies on their inhibition

1978 • 93 citations

Serotoninergic System in Dementia of the Alzheimer Type

1985 • 90 citations

3-(glutathion-S-yl)acetaminophen: a biliary metabolite of acetaminophen.

1982 • 89 citations

Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase.

1988 • 89 citations

2-Fluoroestradiol. Separation of estrogenicity from carcinogenicity.

1983 • 89 citations

Oxygen-dependent reaction of 6-hydroxydopamine, 5,6-dihydroxytryptamine, and related compounds with proteins in vitro: a model for cytotoxicity.

1976 • 88 citations

Ascorbate-quinone interactions: electrochemical, free radical, and cytotoxic properties.

1983 • 84 citations

Detection and identification of sulfhydryl conjugates of p-benzoquinone in microsomal incubations of benzene and phenol

1983 • 84 citations

Kidney Lesions Induced in Rats by P-aminophenol

1969 • 83 citations

Membrane-Bound γ-Glutamyl Transpeptidase

1976 • 82 citations

gamma-Glutamyl transpeptidase: a single copy gene in the rat and a multigene family in the human genome.

1988 • 81 citations

Active site-directed irreversible inhibition of glutathione S-transferases by the glutathione conjugate of tetrachloro-1,4-benzoquinone.

1988 • 81 citations

The formation of mercapturic acids. 3. N-Acetylation of S-substituted cysteines in the rabbit, rat and guinea pig

1959 • 78 citations

Estrogen 2- and 4-hydroxylase activity, catechol estrogen formation, and implications for estrogen carcinogenesis in the hamster kidney.

1985 • 77 citations

Induction of Renal Cell Tumors in Rats and Mice, and Enhancement of Hepatocellular Tumor Development in Mice after Long‐term Hydroquinone Treatment

1991 • 77 citations

Nephrotoxicity of 4-Aminophenol Glutathione Conjugate

1991 • 76 citations

Catecholamine‐Metabolizing Enzymes of Bovine Brain Microvessel Endothelial Cell Monolayers

1986 • 74 citations

Comparative Study of the Sugar Chains of γ-Glutamyltranspeptidases Purified from Human Hepatocellular Carcinoma and from Human Liver1

1989 • 74 citations

One-electron reduction of 2- and 6-methyl-1,4-naphthoquinone bioreductive alkylating agents

1986 • 73 citations

Enzymes of Mercapturic Acid Formation

1980 • 73 citations

Cysteine S-conjugate N-acetyltransferase from rat kidney microsomes.

1982 • 70 citations

Co-polymerization of dopa and cysteinyldopa in melanogenesis in vitro

1980 • 69 citations

Increased Salsolinol Levels in Rat Striatum and Limbic Forebrain Following Chronic Ethanol Treatment

1982 • 67 citations

Reduction and glutathione conjugation reactions of N-acetyl-p-benzoquinone imine and two dimethylated analogues.

1984 • 67 citations

Irreversible inhibition of rat glutathione S-transferase 1-1 by quinones and their glutathione conjugates. Structure-activity relationship and mechanism

1991 • 67 citations

Enzymic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy)methamphetamine by rat brain microsomes

1992 • 67 citations

Enzymic activity of the brain: microvessels vs. total forebrain homogenate

1977 • 66 citations

Possible reactions of 1,2-naphthaquinone in the eye.

1967 • 66 citations

A systematic regional study of brain salsolinol levels during and immediately following chronic ethanol ingestion in rats

1987 • 64 citations

Caftaric acid in grapes and conversion to a reaction product during processing

2016 • 63 citations

2-Bromo-(diglutathion-S-yl)hydroquinone nephrotoxicity: physiological, biochemical, and electrochemical determinants.

1988 • 63 citations

The toxicity of menadione (2-methyl-1,4-naphthoquinone) and two thioether conjugates studied with isolated renal epithelial cells

1991 • 60 citations

A possible neurochemical mechanism for brain and nerve damage associated with chronic alcoholism

1982 • 57 citations

Effects of 3,4-dihydroxymethamphetamine and 2,4,5-trihydroxymethamphetamine, two metabolites of 3,4-methylenedioxymethamphetamine, on central serotonergic and dopaminergic systems.

1992 • 56 citations

Morphological and immunohistochemical studies of the estrogen-induced Syrian hamster renal tumor: probable cell of origin.

1989 • 53 citations

In vivo murine studies on the biochemical mechanism of naphthalene cataractogenesis

1989 • 52 citations

Salsolinol and dopamine in rat medial basal hypothalamus after chronic ethanol exposure

1985 • 51 citations

NADP-linked 15-hydroxyprostaglandin dehydrogenase from human placenta: Partial purification and characterization of the enzyme and identification of an inhibitor in placental tissue of an inhibitor in placental tissue

1977 • 51 citations

The Addition of Sulfhydryl Derivatives to 2-Methyl-1,4-naphthoquinone¹

1947 • 50 citations

Catecholamine derived compounds in urine and cerebrospinal fluid from alcoholics during and after long-standing intoxication.

1981 • 50 citations

Possible reactions of 1,2-naphthaquinone in the eye

1967 • 49 citations

Glutathione s-transferases and drug resistance

1991 • 48 citations

Substrate specificity of three prostaglandin dehydrogenases

1983 • 46 citations

Multiple molecular forms of prostaglandin 15-hydroxydehydrogenase and 9-ketoreductase in chicken kidney

1977 • 46 citations

Oxidation of the Indole Nucleus of 5-Hydroxytryptamine and the Formation of Pigments: Isolation and Partial Characterization of a Dimer of 5-Hydroxytryptamine

1960 • 46 citations

Activation and detoxication of aminophenols. II. Synthesis and structural elucidation of various thiol addition products of 1,4-benzoquinoneimine andN-acetyl-1,4-benzoquinoneimine

1990 • 46 citations

Prostaglandin 9-ketoreductase/type II 15-hydroxyprostaglandin dehydrogenase is not a prostaglandin specific enzyme

1981 • 45 citations

Biotransformation of 4-dimethylaminophenol: Reaction with glutathione, and some properties of the reaction products

1976 • 45 citations

Mikrosomale Oxidation des Östradiols-17β. 2-Hydroxylierung und 1- bzw. 4-Thioätherbildung mit und ohne 17-Hydroxyl-Dehydrogenierung

1971 • 45 citations

Endogenous inhibitors of glutathione S-transferases in house flies

1978 • 44 citations

Ah Locus: Genetic Differences in Susceptibility to Cataracts Induced by Acetaminophen

1978 • 42 citations

Studies on the active site of rat glutathione S‐transferase isoenzyme 4–4

1989 • 42 citations

The Interaction of Thiols and Quinones¹

1947 • 42 citations

Transformation of dopamine and .alpha.-methyldopamine by NG108-15 cells: formation of thiol adducts

1991 • 42 citations

Polycyclic aromatic hydrocarbon quinone-mediated oxidation reduction cycling catalyzed by a human placental NADPH-linked carbonyl reductase

1991 • 41 citations

Immunocytochemical localization of γ-glutamyl transpeptidase in the rat CNS

1981 • 40 citations

Conjugation of 2-hydroxyestradiol-17β (1,3,5(10)-estratriene-2,3,17β-triol) with glutathione in the rat

1971 • 38 citations

Cysteinyldopamine is not incorporated into neuromelanin

1991 • 38 citations

Chemical sympathectomy induced by 5.6-dihydroxytryptamine

1972 • 37 citations

The in vivo disposition of 2-bromo-[14C]hydroquinone and the effect of γ-glutamyl transpeptidase inhibition

1990 • 37 citations

Purification and characterization of a rat liver enzyme catalyzing N-deacetylation of mercapturic acid conjugates.

1981 • 35 citations

The Reaction of Quinone and Sulfite. I. Intermediates¹

1952 • 35 citations

Hydroperoxide-dependent activation of p-phenetidine catalyzed by prostaglandin synthase and other peroxidases

1983 • 34 citations

Differences in the localization and extent of the renal proximal tubular necrosis caused by mercapturic acid and glutathione conjugates of 1,4-naphthoquinone and menadione

1990 • 34 citations

Identification of N-acetyl-S-(2,5-dihydroxyphenyl)-L-cysteine as a urinary metabolite of benzene, phenol, and hydroquinone.

1990 • 34 citations

4: Final Report on the Safety Assessment of Hydroquinone and Pyrocatechol

1986 • 34 citations

Characterization of a glutathione conjugate of the 1,4-benzosemiquinone-free radical formed in rat hepatocytes.

1988 • 33 citations

Glutathione, γ-glutamyl transpeptidase, and the mercapturic acid pathway as modulators of 2-bromohydroquinone oxidation

1990 • 33 citations

Ueber die Constitution der Phenochinone, Thiophenochinone und Chinhydrone. Ein Versuch zur einheitlichen Erklärung der Additionsvorgänge beim Chinon

1904 • 33 citations

Ferrihemoglobin and kidney lesions in rats produced by 4-aminophenol or 4-dimethylaminophenol

1975 • 33 citations

Increased serotonin efflux by a partially oxidized serotonin: tryptamine-4,5-dione.

1989 • 32 citations

Metabolism of a glutathione conjugate of 2-hydroxyoestradiol by rat liver and kidney preparations in vitro

1970 • 31 citations

Some new aspects of eumelanin chemistry.

1988 • 31 citations

Studies in the biochemistry of micro-organisms. 79. Fuscin, a metabolic product of Oidiodendron fuscum Robak. Part 1. Preparation, properties and antibacterial activity

1948 • 31 citations

Genetic Differences in Cataract and Other Ocular Abnormalities Induced by Paracetamol and Naphthalene

1980 • 31 citations

Characterization and mechanism of formation of reactive products formed during peroxidase-catalyzed oxidation of p-phenetidine. Trapping of reactive species by reduced glutathione and butylated hydroxyanisole.

1985 • 30 citations

Polycyclic aromatic hydrocarbon quinones and glutathione thioethers as substrates and inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase.

1987 • 30 citations

Oxidative cyclization, 1,4-benzothiazine formation and dimerization of 2-bromo-3-(glutathion-S-yl)hydroquinone.

1990 • 30 citations

Irreversible inhibition of rat hepatic glutathione S-transferase isoenzymes by a series of structurally related quinones

1989 • 29 citations

408. Addition reactions of quinones. Part I. The reaction of cysteine and thiourea and its derivatives with some quinones

1952 • 28 citations

Inhibition of γ-glutamyl transpeptidase potentiates the nephrotoxicity of glutathione-conjugated chlorohydroquinones

1991 • 28 citations

Isolation and purification of multiple forms of ?-glutamyl transpeptidase from rat brain

1980 • 28 citations

Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits*1

1988 • 27 citations

Pro-oxidant activation of ocular reductants. 2. Lens epithelial cell cytotoxicity of a dietary quinone is associated with a stable free radical formed with glutathione in vitro

1987 • 26 citations

Determination of the mechanism of demethylenation of (methylenedioxy)phenyl compounds by cytochrome P450 using deuterium isotope effects

1991 • 26 citations

Activation and detoxication of aminophenols. III. Synthesis and structural elucidation of various glutathione addition products to 1,4-benzoquinone

1990 • 26 citations

Steric effects of vicinal substituents on redox equilibriums in quinoid compounds

1971 • 26 citations

Interaction of benzo- and naphtoquinones with soluble glutathione S-tranferases from rat liver

1983 • 24 citations

Effects of 4-dimethylaminophenol in rat kidneys, isolated rat kidney tubules and hepatocytes

1980 • 24 citations

Epidermal ornithine decarboxylase induction and mouse skin tumor promotion by quinones

1990 • 23 citations

Nephrotoxicity of the glutathione conjugate of menadione (2-methyl-1, 4-naphthoquinone) in the isolated perfused rat kidney. Role of metabolism by gamma-glutamyltranspeptidase and probenecid-sensitive transport.

1991 • 22 citations

Tryptamine-4,5-dione: Properties and reaction with glutathione

1990 • 22 citations

Metabolism of a glutathione conjugate of 2-hydroxyoestradiol-17β in the adult male rat

1972 • 21 citations

Site and mechanism of covalent binding of 4-dimethylaminophenol to human hemoglobin, and its implications to the functional properties.

1983 • 21 citations

Effects of 5,6‐Dihydroxytryptamine on the Release, Synthesis, and Storage of Serotonin: Studies Using Rat Brain Synaptosomes

1988 • 21 citations

Metabolic evidence for the involvement of enzymatic bioactivation in the cataractogenicity of acetaminophen in genetically susceptible (C57BL6) and resistant (DBA2) murine strains

1988 • 20 citations

Uptake of L-glutamine into synaptosomes. Is the γ-glutamyl cycle involved?

1983 • 19 citations

Prostaglandin synthase and horseradish peroxidase catalyzed DNA-binding of p-phenetidine

1984 • 18 citations

5-S-cysteinyldopa as a substrate for tyrosinase

1980 • 18 citations

Synthesis and nephrotoxicity of 6-bromo-2,5-dihydroxy-thiophenol.

1988 • 18 citations

The Reaction of 2-Methyl-1, 4-naphthoquinone with Sulfhydryl Compounds

1968 • 17 citations

Species differences in renal γ-glutamyl transpeptidase activity do not correlate with susceptibility to 2-bromo-(diglutathion-S-yl)-hydroquinone nephrotoxicity

1990 • 17 citations

Interactions of salsolinol with oxidative enzymes

1991 • 17 citations

Nephrotoxicity of 2-bromo-(cystein-s-yl) hydroquinone and 2-bromo-(N-acetyl-l-cystein-S-yl) hydroquinone thioethers

1991 • 17 citations

Reactions of the serotonergic neurotoxin 5, 6-dihydroxytryptamine with glutathione

1991 • 16 citations

Identification and structure characterization of S-containing metabolites of 3-tert-butyl-4-hydroxyanisole in rat urine and liver microsomes.

1991 • 15 citations

Chapter 8: MODIFICATION OF CARCINOGENESIS BY ANTIOXIDANTS AND OTHER COMPOUNDS

1984 • 14 citations

SULPHYDRYL ADDITION COMPOUNDS OF SOME QUINONES AND RELATED SUBSTANCES IN THEIR ACTION ON THE GROWTH OF NORMAL CELLS

1948 • 13 citations

Electrochemical and enzyme-mediated oxidations of tetrahydropapaveroline

1991 • 12 citations

The Mechanism of Paracetamol-induced Hepatotoxicity: Implications for Therapy

1983 • 12 citations

Oxidation chemistry of the endogenous central nervous system alkaloid salsolinol

1991 • 12 citations

Ueber Verbindungen der Aldehyde, Ketone und Ketonsäuren mit der Thioglycolsäure

1888 • 12 citations

Estrogen mercapturic acids in the adult male rat

1973 • 11 citations

Glutathione Conjugation as a Mechanism of Targeting Latent Quinones to the Kidney

1991 • 10 citations

Electrophoretic mobility of γ-glutamyltransferase in rat liver subcellular fractions. Evidence for structure difference from the kidney enzyme

1989 • 9 citations

The Nephrotoxicity of Haloalkane and Haloalkene Glutathione Conjugates

1987 • 9 citations

Glutathione mixed disulfide inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase

1987 • 8 citations

Uniquely, γ-endorphin induces an effect that is both opiate- and neuroleptic-like

1983 • 8 citations

Changes of cerebral gamma glutamyltransferase activities after treatment with exogenous inducers

1987 • 7 citations

[Microsomal oxidation of estradiol-17 beta. 2-hydroxylation and 1- respectively 4- thioether production with and without 17-hydroxy dehydrogenation].

1971 • 6 citations

GLUTATHIONE CONJUGATES: TRANSPORT FROM THE CELL AND INTRACELLULAR EFFECTS

1989 • 6 citations

[Metabolism of oestrone in the microsomal fraction of rat liver (author's transl)].

1974 • 2 citations

Response : Quartz Cleavage and Quick Clays

1974 • 2 citations