Effect of acute monoamine depletion on 3,4-methylenedioxymethamphetamine-induced neurotoxicity

Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity

1988 • 548 citations

Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.

1987 • 526 citations

Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.

1987 • 451 citations

Methamphetamine neurotoxicity and striatal glutamate release: comparison to 3, 4-methylenedioxymethamphetamine

1992 • 357 citations

Role of dopamine in the neurotoxic effects of methamphetamine.

1985 • 299 citations

Characterization of [3H]paroxetine binding to rat cortical membranes

1985 • 257 citations

Formation of 6-hydroxydopamine in caudate nucleus of the rat brain after a single large dose of methylamphetamine

1984 • 224 citations

The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat

1988 • 224 citations

Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct.

1990 • 195 citations

Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat

1987 • 186 citations

Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine.

1988 • 186 citations

Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate

1991 • 143 citations

Microdialysis studies on 3,4-methylenedioxymethamphetamine-induced dopamine release: effect of dopamine uptake inhibitors.

1991 • 127 citations

In vivo and in vitro metabolism of 3,4-(methylenedioxy)methamphetamine in the rat: identification of metabolites using an ion trap detector

1988 • 118 citations

Ketanserin pretreatment attenuates MDMA-induced dopamine release in the striatum as measured by microdialysis

1990 • 114 citations

Neuroanatomic specificity and time course of alterations in rat brain serotonergic pathways induced by MDMA (3,4-methylenedioxymethamphetamine): Assessment using quantitative autoradiography

1991 • 113 citations

Reversible and irreversible phases of serotonin depletion by 4-chloroamphetamine

1975 • 109 citations

A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis

1990 • 103 citations

[3H]Monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetaimne and p-chloroamphetamine analogues

1991 • 102 citations

3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine

1991 • 91 citations

Effects of methylenedioxymethamphetamine on the release of monoamines from rat brain slices

1990 • 86 citations

Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine

1990 • 86 citations

Enantiomeric differences in the effects of 3,4-methylenedioxymethamphetamine on extracellular monoamines and metabolites in the striatum of freely-moving rats: An in vivo microdialysis study

1990 • 82 citations

[3H]Paroxetine Binding and Serotonin Content of Rat Cortical Areas, Hippocampus, Neostriatum, Ventral Mesencephalic Tegmentum, and Midbrain Raphe Nuclei Region Following p‐Chlorophenylalanine and p‐Chloroamphetamine Treatment

1992 • 79 citations

5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa.

1991 • 78 citations

α-Methyl-p-tyrosine pretreatment partially prevents methamphetamine-induced endogenous neurotoxin formation

1990 • 73 citations

Microdialysis studies on 3,4-methylenedioxyamphetamine and structurally related analogues

1991 • 63 citations

Endogenously produced 5,6-dihydroxytryptamine may mediate the neurotoxic effects of para-chloroamphetamine

1987 • 58 citations

Effects of 3,4-dihydroxymethamphetamine and 2,4,5-trihydroxymethamphetamine, two metabolites of 3,4-methylenedioxymethamphetamine, on central serotonergic and dopaminergic systems.

1992 • 56 citations

Effect of 3,4‐Methylenedioxymethamphetamine on 3,4‐Dihydroxyphenylalanine Accumulation in the Striatum and Nucleus Accumbens

1990 • 56 citations

Neurotoxic effects of partially oxidized serotonin: tryptamine-4,5-dione

1989 • 44 citations

In vivo formation of aromatic hydroxylated metabolites of 3,4-(methylenedioxy)methamphetamine in the rat: Identification by ion trap tandem mass spectrometric (MS/MS and MS/MS/MS) techniques

1991 • 38 citations

Quinolinate and kainate neurotoxicity in neostriatal cultures is potentiated by co-culturing with neocortical neurons

1990 • 33 citations

Increased serotonin efflux by a partially oxidized serotonin: tryptamine-4,5-dione.

1989 • 32 citations

Depletion of serotonin using p-chlorophenylalanine (PCPA) and reserpine protects against the neurotoxic effects of p-chloroamphetamine (PCA) in the brain

1989 • 30 citations

Effect of 3,4-methylenedioxymethamphetamine on [3H]paroxetine binding in the frontal cortex and blood platelets of rats

1991 • 23 citations

α-Methyl-p-tyrosine partially attenuates p-chloroamphetamine-induced 5-hydroxytryptamine depletions in the rat brain

1990 • 14 citations

Assessment of the role of α-methylapinine in the neurotoxicity of MDMA

1991 • 14 citations

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