Degradation of a Nonpolyadenylated Messenger: Histone mRNA Decay

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.

1991 • 795 citations

Do the poly(A) tail and 3′ untranslated region control mRNA translation?

1990 • 618 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation

1989 • 561 citations

Identification of an AUUUA-Specific Messenger RNA Binding Protein

1989 • 515 citations

Regulation of human histone gene expression: kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mRNAs during the HeLa cell cycle.

1983 • 452 citations

Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation

1990 • 364 citations

Binding of a Cytosolic Protein to the Iron-Responsive Element of Human Ferritin Messenger RNA

1988 • 363 citations

Poly(A), poly(A) binding protein and the regulation of mRNA stability

1989 • 355 citations

mRNA poly(A) tail, a 3' enhancer of translational initiation.

1990 • 353 citations

Separation of basal histone synthesis from S-phase histone synthesis in dividing cells

1981 • 352 citations

Translation is required for regulation of histone mRNA degradation

1987 • 345 citations

Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulin

1988 • 345 citations

EXPRESSION AND ORGANIZATION OF HISTONE GENES

1983 • 309 citations

Histone mRNA concentrations are regulated at the level of transcription and mRNA degradation.

1983 • 298 citations

Sperm decondensation in Xenopus egg cytoplasm is mediated by nucleoplasmin

1991 • 281 citations

Two complexes that contain histones are required for nucleosome assembly in vitro: Role of nucleoplasmin and N1 in Xenopus egg extracts

1987 • 271 citations

Cap recognition and the entry of mRNA into the protein synthesis initiation cycle

1988 • 256 citations

The stem-loop structure at the 3' end of histone mRNA is necessary and sufficient for regulation of histone mRNA stability.

1987 • 238 citations

Regulation of Histone mRNA in the Unperturbed Cell Cycle: Evidence Suggesting Control at Two Posttranscriptional Steps

1991 • 224 citations

The synthesis and storage of histones during the oogenesis of Xenopus laevis

1977 • 221 citations

Identification of the Human U7 snRNP as One of Several Factors Involved in the 3′ End Maturation of Histone Premessenger RNA's

1987 • 221 citations

Multiple regulatory steps control histone mRNA concentrations

1988 • 199 citations

Regulation of histone mRNA in the unperturbed cell cycle: evidence suggesting control at two posttranscriptional steps.

1991 • 189 citations

Regulation of histone mRNA production and stability in serum-stimulated mouse 3T6 fibroblasts.

1983 • 186 citations

H4 histone messenger RNA decay in cell-free extracts initiates at or near the 3′ terminus and proceeds 3′ to 5′

1986 • 179 citations

Histone Genes: Structure, Organization and Regulation

1985 • 177 citations

Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs.

1985 • 172 citations

Translational control by cytoplasmic polyadenylation during Xenopus oocyte maturation: characterization of cis and trans elements and regulation by cyclin/MPF.

1990 • 165 citations

Cell cycle regulation of mouse H3 histone mRNA metabolism.

1984 • 165 citations

Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation.

1989 • 162 citations

H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3′ processing signals

1989 • 155 citations

In the beginning is the end: regulation of poly(A) addition and removal during early development

1990 • 153 citations

Generation of histone mRNA 3′ ends by endonucleolytic cleavage of the pre-mRNA in a snRNP-dependent in vitro reaction.

1986 • 151 citations

Control of histone synthesis in HeLa cells

1973 • 148 citations

Further evidence of transcriptional and translational control of histone messenger RNA during the HeLa S3 cycle

1975 • 145 citations

Faithful cell-cycle regulation of a recombinant mouse histone H4 gene is controlled by sequences in the 3'-terminal part of the gene.

1985 • 128 citations

Inhibition of protein synthesis stabilizes histone mRNA.

1984 • 122 citations

Replacement Variant Histone Genes Contain Intervening Sequences

1985 • 116 citations

Histone 3' ends: essential and regulatory functions.

1992 • 115 citations

Coupling of replication type histone mRNA levels to DNA synthesis requires the stem-loop sequence at the 3' end of the mRNA.

1987 • 110 citations

Properties of the exonuclease activity that degrades H4 histone mRNA.

1987 • 102 citations

Poly(A) Tail Shortening Is the Translation-Dependent Step in c-myc mRNA Degradation

1990 • 100 citations

Rapid reversible changes in the rate of histone gene transcription and histone mRNA levels in mouse myeloma cells.

1984 • 100 citations

Histone mRNA Degradation In Vivo: the First Detectable Step Occurs at or near the 3′ Terminus

1986 • 98 citations

Genetic complementation in the Xenopus oocyte: co-expression of sea urchin histone and U7 RNAs restores 3′ processing of H3 pre-mRNA in the oocyte.

1986 • 96 citations

Control of the higher eukaryote cell cycle by p34cdc2 homologues

1989 • 94 citations

Heat-labile regulatory factor is required for 3' processing of histone precursor mRNAs.

1987 • 90 citations

Autogenous Regulation of Histone mRNA Decay by Histone Proteins in a Cell-Free System

1987 • 82 citations

Quantitative and qualitative changes in histone gene expression during early mouse embryo development.

1985 • 82 citations

Multiple, independently regulated, polyadenylated messages for histone H3 and H4 inTetrahymena

1983 • 79 citations

Kinetics of inactivation of histone mRNA in the cytoplasm after inhibition of DNA replication in synchronised HeLa cells

1975 • 79 citations

Conserved terminal hairpin sequences of histone mRNA precursors are not involved in duplex formation with the U7 RNA but act as a target site for a distinct processing factor.

1989 • 78 citations

Structure of a cluster of mouse histone genes

1983 • 76 citations

Yeast histone mRNA is polyadenylated

1980 • 74 citations

3' processing of pre-mRNA plays a major role in proliferation-dependent regulation of histone gene expression

1988 • 69 citations

Replacement variant histone genes contain intervening sequences.

1985 • 69 citations

Different 3'-end processing produces two independently regulated mRNAs from a single H1 histone gene.

1989 • 65 citations

Different complexes are formed on the 3′ end of histone mRNA with Nuclear and polyribosomal proteins

1991 • 64 citations

The human histone H2A.Z gene. Sequence and regulation.

1990 • 62 citations

Each of the conserved sequence elements flanking the cleavage site of mammalian histone pre-mRNAs has a distinct role in the 3'-end processing reaction.

1989 • 61 citations

On the Translational Control of Histone Synthesis

1974 • 59 citations

Substrate specificity of the exonuclease activity that degrades H4 histone mRNA.

1987 • 58 citations

Fate of Histone Messenger RNA in Synchronized HeLa Cells in the Absence of Initiation of Protein Synthesis

1977 • 57 citations

The histone mRNA 3′ end is required for localization of histone mRNA to polyribosomes

1992 • 57 citations

Changes in the stability of a human H3 histone mRNA during the HeLa cell cycle.

1991 • 56 citations

Kinetics of accumulation and depletion of soluble newly synthesized histone in the reciprocal regulation of histone and DNA synthesis

1988 • 56 citations

Translation of c-myc mRNA is required for its post-transcriptional regulation during myogenesis.

1990 • 54 citations

Poly(A) tail shortening is the translation-dependent step in c-myc mRNA degradation.

1990 • 50 citations

Remodeling of sperm chromatin following fertilization: Nucleosome repeat length and histone variant transitions in the absence of DNA synthesis

1984 • 49 citations

Histone mRNA degradation in vivo: the first detectable step occurs at or near the 3' terminus.

1986 • 48 citations

Autogenous regulation of histone mRNA decay by histone proteins in a cell-free system.

1987 • 45 citations

Interrelationships of protein and DNA syntheses during replication of mammalian cells.

1985 • 43 citations

Polyadenylation and U7 snRNP-mediated cleavage: alternative modes of RNA 3' processing in two avian histone H1 genes.

1989 • 36 citations

Cisacting Sequences that Modulate Transcription of Wheat Histone H3 and 3′ Processing of H3 Premature mRNA

1989 • 35 citations

Stabilization of Tubulin mRNA by Inhibition of Protein Synthesis in Sea Urchin Embryos

1988 • 27 citations

Uncoordinated synthesis of histones and DNA by mouse eggs and preimplantation embryos

1983 • 16 citations

Stabilization of tubulin mRNA by inhibition of protein synthesis in sea urchin embryos.

1988 • 13 citations

Exonuclease activity that degrades histone mRNA is stable when DNA or protein synthesis is inhibited.

1989 • 8 citations