Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

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1980 • 15,302 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Erythropoietin: structure, control of production, and function

1992 • 1,158 citations

Cloning and expression of the human erythropoietin gene.

1985 • 1,144 citations

Isolation and characterization of genomic and cDNA clones of human erythropoietin

1985 • 1,101 citations

Luciferase reporter gene vectors for analysis of promoters and enhancers.

1988 • 1,016 citations

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.

1991 • 932 citations

Role of the Kidney in Erythropoiesis

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The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements

1988 • 679 citations

Evolution of the nuclear receptor gene superfamily.

1992 • 662 citations

Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines.

1989 • 614 citations

A High-Efficiency HeLa Cell Nuclear Transcription Extract

1988 • 612 citations

The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors

1991 • 603 citations

Repetitive Sequences in Eukaryotic DNA and their Expression

1982 • 575 citations

Modular structure of a chicken lysozyme silencer: Involvement of an unusual thyroid hormone receptor binding site

1990 • 487 citations

A haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti

1991 • 477 citations

Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.

1992 • 389 citations

Regulation of the Apolipoprotein AI Gene by ARP-1, a Novel Member of the Steroid Receptor Superfamily

1991 • 382 citations

The regulated expression of erythropoietin by two human hepatoma cell lines.

1987 • 374 citations

Regulation of Progesterone Receptor-Mediated Transcription by Phosphorylation

1990 • 365 citations

Cloning and expression of the hyman erythropoietin gene

1985 • 353 citations

Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression

1991 • 303 citations

Fos-Jun heterodimers and jun homodimers bend DNA in opposite orientations: Implications for transcription factor cooperativity

1991 • 296 citations

Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene.

1991 • 260 citations

Gene Regulation by Steroid Hormones

1990 • 255 citations

Heterologous expression of a bacterial haemoglobin improves the growth properties of recombinant Escherichia coli

1988 • 235 citations

Liver as the primary site of erythropoietin formation in the fetus.

1977 • 219 citations

A retinoic acid-responsive element in the apolipoprotein AI gene distinguishes between two different retinoic acid response pathways.

1991 • 217 citations

Enhancer element at the 3'-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene

1991 • 209 citations

Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events

1991 • 202 citations

Murine erythropoietin gene: cloning, expression, and human gene homology.

1986 • 193 citations

Expression of the Erythropoietin Gene

1986 • 182 citations

Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure

1989 • 170 citations

Mobility Shift <scp>DNA</scp>‐Binding Assay Using Gel Electrophoresis

1996 • 167 citations

Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene.

1986 • 153 citations

Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements.

1990 • 126 citations

Oxygen regulation of anaerobic and aerobic genes mediated by a common factor in yeast.

1984 • 119 citations

Regulation of Gene Expression by Retinoic Acid Receptors

1991 • 103 citations

The effect of oxygen on the concentration of haem in invertebrates

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Modulator sequences mediate oxygen regulation of CYC1 and a neighboring gene in yeast.

1983 • 94 citations

Antagonism between Retinoic Acid Receptors

1991 • 91 citations

Nuclear hormone receptors — Molecular mechanisms, cellular functions, clinical abnormalities

1992 • 83 citations

A hypoxic consensus operator and a constitutive activation region regulate the ANB1 gene of Saccharomyces cerevisiae.

1990 • 71 citations

Ligand and DNA-dependent phosphorylation of human progesterone receptor in vitro.

1992 • 69 citations

Enhancement by hypoxia of human erythropoietin gene transcription in vitro.

1990 • 59 citations

Antagonism between retinoic acid receptors.

1991 • 55 citations

Murine Erythropoietin Gene: Cloning, Expression, and Human Gene Homology

1986 • 48 citations

Evidence suggesting negative regulation of the erythropoietin gene by ribonucleoprotein.

1990 • 48 citations

Mobility Shift DNA‐Binding Assay Using Gel Electrophoresis

1988 • 44 citations

Cloning, Sequencing, and Evolutionary Analysis of the Mouse Erythropoietin Gene

1986 • 39 citations

DNA Makes RNA Makes PROTEIN

1983 • 30 citations

Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure

1989 • 17 citations

The human Alu family of repeated DNA sequences

1982 • 14 citations

Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events

1991 • 13 citations

Activation of the Erythropoietin Gene Due to the Proximity of an Expressed Gene

1989 • 11 citations

Erythropoietin in clinical applications : an international perspective

1990 • 11 citations