Interleukin-1: Biology, pathophysiology, and clinical prospects
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Abstract
References (139)
Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer
1985 • 2,616 citations
The biology of interleukin-6
1989 • 1,964 citations
Interleukin-1
1984 • 1,625 citations
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
1985 • 1,594 citations
Biology of interleukin 1
1988 • 1,547 citations
Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
1986 • 1,521 citations
Interleukin-1 Stimulates the Secretion of Hypothalamic Corticotropin-Releasing Factor
1987 • 1,512 citations
Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.
1986 • 1,501 citations
The biology of interleukin-6
1989 • 1,459 citations
There is more than one interleukin 1
1986 • 1,226 citations
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.
1984 • 1,042 citations
Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells.
1984 • 944 citations
POTENTIATION OF THE T-LYMPHOCYTE RESPONSE TO MITOGENS
1972 • 921 citations
Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury
1985 • 855 citations
Cloning and expression of murine interleukin-1 cDNA in Escherichia coli
1984 • 820 citations
Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1
1986 • 781 citations
Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Hematopoietic Reconstitution after High-Dose Chemotherapy and Autologous Bone Marrow Transplantation
1988 • 779 citations
Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus
1988 • 771 citations
POTENTIATION OF THE T-LYMPHOCYTE RESPONSE TO MITOGENS
1972 • 742 citations
Tumor Necrosis Factor and Interleuktn-1 in the Serum of Children with Severe Infectious Purpura
1988 • 735 citations
Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.
1987 • 690 citations
Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.
1986 • 632 citations
Interleukin l and T Cell Activation
1982 • 622 citations
B-Cell Stimulatory Factor-1/Interleukin 4
1987 • 602 citations
Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.
1986 • 585 citations
IL-1 stimulates IL-6 production in endothelial cells.
1989 • 541 citations
Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2.
1986 • 534 citations
Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.
1984 • 529 citations
Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor.
1981 • 516 citations
Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.
1988 • 510 citations
Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells.
1986 • 496 citations
Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness.
1989 • 493 citations
CORRELATION OF PLASMA INTERLEUKIN 1 LEVELS WITH DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS
1988 • 490 citations
Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2.
1986 • 458 citations
Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE).
1983 • 453 citations
Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1.
1985 • 423 citations
Interleukin 1 is a radioprotector.
1986 • 386 citations
Synergy of interleukin 1 and granulocyte colony-stimulating factor: in vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice.
1987 • 380 citations
Human interleukin 1 is a cytocidal factor for several tumor cell lines.
1985 • 380 citations
Multiple biological activities of human recombinant interleukin 1.
1986 • 372 citations
An update on human interleukin-1: From molecular biology to clinical relevance
1985 • 372 citations
Interleukin 2 Regulates Expression of Its Receptor and Synthesis of Gamma Interferon by Human T Lymphocytes
1984 • 350 citations
Circulating Activated Suppressor T Lymphocytes in Aplastic Anemia
1985 • 349 citations
Affinity-purified human Interleukin I is cytotoxic to isolated islets of Langerhans
1986 • 321 citations
Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1.
1987 • 309 citations
Interleukin 1 activity in the synovial fluid of patients with rheumatoid arthritis
1982 • 304 citations
Regulation of very primitive, multipotent, hemopoietic cells by hemopoietin-1
1986 • 283 citations
Monocyte-Derived Human B-Cell Growth Factor Identified as Interferon-β 2 (BSF-2, IL-6)
1988 • 281 citations
Interdependence of the radioprotective effects of human recombinant interleukin 1 alpha, tumor necrosis factor alpha, granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor.
1988 • 265 citations
Interleukin 1 is more than an interleukin
1982 • 257 citations
Inducible interleukin-1 gene expression in human vascular smooth muscle cells.
1986 • 256 citations
Molecular basis of fever in humans
1982 • 252 citations
Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in acute myeloblastic leukemia.
1987 • 239 citations
Additive effects of interleukin 1 and tumour necrosis factor-alpha on the accumulation of the three granulocyte and macrophage colony-stimulating factor mRNAs in human endothelial cells.
1987 • 238 citations
Tumor necrosis factor-alpha enhances cytolytic activity of human natural killer cells.
1987 • 235 citations
Macrophage Inflammatory Protein-1: a Prostaglandin-Independent Endogenous Pyrogen
1989 • 222 citations
Recombinant human tumor necrosis factor administered as a five-day continuous infusion in cancer patients: phase I toxicity and effects on lipid metabolism.
1988 • 217 citations
Human large granular lymphocytes are potent producers of interleukin-1
1984 • 212 citations
Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor.
1987 • 212 citations
Secretion of interleukin-1 by acute myeloblastic leukemia cells in vitro induces endothelial cells to secrete colony stimulating factors
1987 • 210 citations
Natural and recombinant human interleukin 1-beta is cytotoxic for human melanoma cells.
1986 • 207 citations
Interleukin 1 production by human polymorphonuclear neutrophils.
1986 • 205 citations
Stimulation of Myelopoiesis in Patients with Aplastic Anemia by Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor
1988 • 188 citations
Generation of activated killer (AK) cells by recombinant interleukin 2 (rIL 2) in collaboration with interferon-gamma (IFN-gamma).
1985 • 184 citations
Regulation of the expression of IL-6 in human monocytes.
1989 • 176 citations
Induction of membrane-associated interleukin 1 by tumor necrosis factor in human fibroblasts.
1987 • 174 citations
Macrophage cytotoxicity: interleukin 1 as a mediator of tumor cytostasis.
1986 • 168 citations
Hematologic effects of immunotherapy with lymphokine-activated killer cells and recombinant interleukin-2 in cancer patients
1987 • 166 citations
Treatment of refractory aplastic anemia with recombinant human granulocyte-macrophage-colony-stimulating factor
1989 • 160 citations
The role of interleukin 1 in human B cell activation: inhibition of B cell proliferation and the generation of immunoglobulin-secreting cells by an antibody against human leukocytic pyrogen.
1983 • 159 citations
The effects of interleukin 1 on human B cell activation and proliferation.
1983 • 151 citations
Interleukin 1 stimulates T lymphocytes to produce granulocyte-monocyte colony-stimulating factor.
1988 • 150 citations
Interleukin 1 as an autocrine growth factor for acute myeloid leukemia cells.
1989 • 149 citations
Interleukin-1 (22-K factor) induces release of granulocyte-macrophage colony-stimulating activity from human mononuclear phagocytes
1986 • 146 citations
Role of interleukin-1 in the depression of liver drug metabolism by endotoxin
1986 • 142 citations
Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma
1989 • 141 citations
The differential effects of human leukocyte pyrogen/lymphocyte-activating factor, T cell growth factor, and interferon on human natural killer activity.
1982 • 138 citations
Modulation of endothelial cell functions by different molecular species of interleukin 1
1987 • 137 citations
Role of interleukin 1 in promoting human monocyte-mediated tumor cytotoxicity.
1985 • 133 citations
Constitutive expression of the interleukin-6 gene in chronic lymphocytic leukemia
1989 • 126 citations
Lymphokine abnormalities in aplastic anemia: implications for the mechanism of action of antithymocyte globulin
1985 • 126 citations
Effect of autolymphocyte therapy on survival and quality of life in patients with metastatic renal-cell carcinoma
1990 • 123 citations
Immunobiologic differences between normal and leukemic human B-cell precursors.
1988 • 123 citations
Cellular interactions in the immune response
1972 • 122 citations
In vitro growth of cytotoxic human lymphocytes. I. Growth of cells sensitized in vitro to alloantigens.
1978 • 121 citations
Interleukin-1 inhibits follicle stimulating hormone-induced differentiation in rat granulosa cells in vitro
1987 • 114 citations
Production of intra- and extracellular interleukin-1 (IL-1) by human monocytes
1984 • 114 citations
T cell receptor triggering induces responsiveness to interleukin 1 and interleukin 2 but does not lead to T cell proliferation.
1986 • 113 citations
In vivo administration of recombinant human granulocyte/macrophage colony-stimulating factor in acute lymphoblastic leukemia patients receiving purged autografts [see comments]
1989 • 113 citations
Expression of myelomonocytic antigens on chronic lymphocytic leukemia B cells correlates with their ability to produce interleukin 1
1987 • 103 citations
Interleukin 1 stimulates its own receptor expression on human fibroblasts through the endogenous production of prostaglandin(s).
1988 • 99 citations
In vitro production of interleukin 1 by normal and malignant human B lymphocytes.
1986 • 90 citations
Potential role of interleukin-1 as the trigger for diffuse intravascular coagulation in acute nonlymphoblastic leukemia
1988 • 89 citations
Increased Interleukin-1 Production and Monocyte Suppressor Cell Activity Associated with Human Tuberculosis1,2
1986 • 87 citations
Induction of receptors for interleukin 2 requires T cell Ag:Ia receptor crosslinking and interleukin 1.
1984 • 86 citations
Affinity purification and chemical analysis of the interleukin-1 receptor.
1988 • 86 citations
Conditions required for expression of membrane IL 1 on B cells.
1985 • 84 citations
Leukemic B-cell precursors express functional receptors for human interleukin-3
1989 • 82 citations
IL-6 is an intermediate in IL-1-induced thymocyte proliferation.
1989 • 81 citations
Effects of interleukin-1 on hematopoietic progenitors: evidence of stimulatory and inhibitory activities in a primate model
1989 • 79 citations
Antidiabetic effects of interleukin 1.
1989 • 77 citations
Synergy of human recombinant interleukin 1 with interleukin 2 in the generation of lymphokine-activated killer cells.
1989 • 74 citations
In vitro expression of colony-stimulating factor genes by human acute myeloblastic leukemia cells.
1988 • 70 citations
Regulation of early human hematopoietic (BFU-E and CFU-GEMM) progenitor cells in vitro by interleukin 1-induced fibroblast-conditioned medium
1987 • 70 citations
Lymphocyte-activating and growth-inhibitory activities for several sources of native and recombinant interleukin 1.
1986 • 69 citations
A synergistic interaction of IL-6 and IL-1 mediates the thymocyte-stimulating activity produced by recombinant IL-1-stimulated fibroblasts.
1989 • 68 citations
Antitumor effects of recombinant human interleukin 1 alpha in RIF-1 and Panc02 solid tumors.
1988 • 59 citations
The role of interleukin 1 (IL 1) in tumor-NK cell interactions: correction of defective NK cell activity in cancer patients by treating target cells with IL 1.
1985 • 59 citations
Paraneoplastic syndrome of hypercalcemia and leukocytosis caused by squamous carcinoma cells (T3M-1) producing parathyroid hormone-related protein, interleukin 1 alpha, and granulocyte colony-stimulating factor.
1989 • 58 citations
Interleukin-1 decreases renal sodium reabsorption: possible mechanism of endotoxin-induced natriuresis
1987 • 52 citations
rIL 2-induced proliferation of human circulating NK cells and T lymphocytes: synergistic effects of IL 1 and IL 2.
1987 • 49 citations
Interleukin-1 alpha enhances the in vitro survival of purified murine granulocyte-macrophage progenitor cells in the absence of colony- stimulating factors
1988 • 49 citations
Stimulation of the release of a B cell-activating factor from human monocytes
1976 • 47 citations
Autocrine stimulation of interleukin 1 alpha in the growth of adult human T-cell leukemia cells.
1989 • 46 citations
Cytokine gene expression during the generation of human lymphokine-activated killer cells: early induction of interleukin 1 beta by interleukin 2.
1989 • 45 citations
Decreased interleukin 1 production in aplastic anaemia
1989 • 45 citations
Spontaneous production of interleukin 1 activity by chronic lymphocytic leukemic cells
1987 • 43 citations
Epidermal cytokines: properties of epidermal cell thymocyte-activating factor (ETAF).
1984 • 42 citations
Regulation of early human hematopoietic (BFU-E and CFU-GEMM) progenitor cells in vitro by interleukin 1-induced fibroblast-conditioned medium
1987 • 42 citations
Polypeptides controlling hematopoietic cell development and activation
1989 • 40 citations
Decrease in interleukin 2-induced vascular leakage in the lungs of mice by administration of recombinant interleukin 1 alpha in vivo.
1989 • 38 citations
IL 1 expression in a clone of human T cells.
1987 • 38 citations
Lymphocyte phenotype and lymphokines following anti‐thymocyte globulin therapy in patients with aplastic anaemia
1987 • 37 citations
Destruction of tumor cells by monokines released from activated human blood monocytes: evidence for parallel and additive effects of IL-1 and TNF
1988 • 37 citations
Interleukin 1 production by peripheral blood mononuclear cells from leprosy patients
1984 • 37 citations
Why Should Internists Be Interested in Interleukin-1?
1988 • 36 citations
Decreased interleukin-1 production in aplastic anemia
1988 • 34 citations
Membrane-associated interleukin 1 alpha as a mediator of tumor cell killing by human blood monocytes fixed with paraformaldehyde.
1989 • 34 citations
Astrocyte-derived interleukin-1-like factors.
1984 • 33 citations
Activation of normal human B cells through their antigen receptor induces membrane expression of IL-1 alpha and secretion of IL-1 beta.
1989 • 32 citations
Leukemic B-cell precursors constitutively express functional receptors for human interleukin-1
1989 • 31 citations
Impairment of monocyte functions in advanced head and neck cancer
1988 • 27 citations
Lymphocytes and lymphokines in aplastic anemia: pathogenic role and implications for pathogenesis.
1987 • 26 citations
Prevention of doxorubicin-induced hematotoxicity in mice by interleukin 1.
1989 • 25 citations
Influence of IL-1 alpha and -1 beta on the survival of human bone marrow cells responding to hematopoietic colony-stimulating factors.
1989 • 21 citations
Role of recombinant interleukin-1 compared to recombinant T-cell replacing factor/interleukin-5 in B-cell differentiation.
1988 • 20 citations
Reduction of radioantibody-induced myelotoxicity in hamsters by recombinant interleukin-1.
1988 • 20 citations
Defective interleukin-1 production by natural killer cells of patients with cancer
1985 • 15 citations
New approaches to the immunotherapy of cancer
1994 • 15 citations