The IRS-signalling system in insulin and cytokine action

Protein modules and signalling networks

1995 • 2,447 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Pathogenesis of NIDDM: A Balanced Overview

1992 • 2,111 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

The insulin signaling system.

1994 • 1,733 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

Signaling by the cytokine receptor superfamily: JAKs and STATs

1994 • 659 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins

1994 • 501 citations

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

1992 • 471 citations

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.

1993 • 452 citations

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

1994 • 436 citations

IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

1993 • 401 citations

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1988 • 368 citations

Phosphotyrosine-Dependent Interaction of SHC and Insulin Receptor Substrate 1 with the NPEY Motif of the Insulin Receptor via a Novel Non-SH2 Domain

1995 • 368 citations

Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid

1995 • 360 citations

Expression and function of IRS-1 in insulin signal transmission.

1992 • 331 citations

PH domain: the first anniversary

1994 • 318 citations

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

1994 • 306 citations

Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.

1994 • 305 citations

A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor.

1994 • 282 citations

Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains

1995 • 276 citations

Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1

1995 • 246 citations

Regulation of Phosphatidylinositol 3′-Kinase by Tyrosyl Phosphoproteins

1995 • 222 citations

Role of IRS-1-GRB-2 complexes in insulin signaling.

1994 • 215 citations

Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.

1994 • 212 citations

Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.

1994 • 200 citations

Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase

1991 • 198 citations

Regions of the JAK2 Tyrosine Kinase Required for Coupling to the Growth Hormone Receptor

1995 • 176 citations

Insulin Receptors, Receptor Antibodies, and the Mechanism of Insulin Action

1981 • 170 citations

Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system.

1994 • 170 citations

Characterization of an endogenous substrate of the insulin receptor in cultured cells.

1987 • 136 citations

How Cells Absorb Glucose

1992 • 120 citations

Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling.

1993 • 116 citations

Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor

1993 • 106 citations

Effect of Cellular Expression of Pleckstrin Homology Domains on Gi-coupled Receptor Signaling

1995 • 87 citations

Association of Insulin Receptor Substrate 1 with Simian Virus 40 Large T Antigen

1995 • 83 citations

Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.

1993 • 80 citations

A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation

1994 • 76 citations

Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity

1993 • 63 citations

PI-3-Kinase Inhibitor Wortmannin Blocks the Insulin-Like Effects of Growth Hormone in Isolated Rat Adipocytes

1994 • 60 citations

A role for Raf-1 in the divergent signaling pathways mediating insulin-stimulated glucose transport

1994 • 48 citations

Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells

1992 • 40 citations

Signaling by the cytokine receptor superfamily just another kinase story

1994 • 27 citations

Immunochemical Studies Relating to Cholecystokinin in Brain and Gut

1981 • 25 citations

Detection of a complex of SV40 large tumor antigen and 53K cellular protein on the surface of SV40‐transformed mouse cells

1982 • 23 citations