Insulin Receptors, Receptor Antibodies, and the Mechanism of Insulin Action

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

1978 • 1,530 citations

The Syndromes of Insulin Resistance and Acanthosis Nigricans

1976 • 1,086 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by

1972 • 831 citations

Primary structure of human insulin‐like growth factor II

1978 • 776 citations

Insulin interactions with its receptors: Experimental evidence for negative cooperativity

1973 • 717 citations

Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells.

1978 • 678 citations

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

1976 • 601 citations

Membrane receptors for hormones and neurotransmitters.

1976 • 573 citations

Insulin Receptors in the Liver: Specific Binding of [ ¹²⁵ I]Insulin to the Plasma Membrane and Its Relation to Insulin Bioactivity

1971 • 494 citations

Insulin-Receptor Interactions in Adipose Tissue Cells: Direct Measurement and Properties

1971 • 443 citations

Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance

1975 • 434 citations

Myasthenic Antibodies Cross-Link Acetylcholine Receptors to Accelerate Degradation

1978 • 425 citations

Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.

1979 • 422 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Insulin Interactions with Liver Plasma Membranes

1972 • 396 citations

Direct demonstration that receptor crosslinking or aggregation is important in insulin action

1978 • 388 citations

Generation by Insulin of a Chemical Mediator That Controls Protein Phosphorylation and Dephosphorylation

1979 • 373 citations

Physiology of Insulin In Man: The Banting Memorial Lecture 1971

1971 • 353 citations

Direct Demonstration of Separate Receptors for Growth and Metabolic Activities of Insulin and Multiplication-stimulating Activity (an Insulinlike Growth Factor) Using Antibodies to the Insulin Receptor

1980 • 346 citations

Binding and degradation of 125I-labelled insulin by isolated rat fat cells

1973 • 339 citations

Insulin-Like Activity of Concanavalin A and Wheat Germ Agglutinin—Direct Interactions with Insulin Receptors

1973 • 310 citations

Properties of the Insulin Receptor Isolated from Liver and Fat Cell Membranes

1972 • 299 citations

The Insulin Receptor: Its Role in Insulin Resistance of Obesity and Diabetes

1976 • 289 citations

Peptide hormone binding to receptors: A review of direct studies in vitro

1973 • 286 citations

Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factor

1979 • 277 citations

Interactions of Insulin-Like Growth Factors I and II and Multiplication-Stimulating Activity with Receptors and Serum Carrier Proteins

1980 • 254 citations

Chemistry of Insulin

1959 • 249 citations

Alterations in Insulin Binding Induced by Changes in Vivo in the Levels of Glucocorticoids and Growth Hormone*

1978 • 246 citations

Nonsuppressible insulin-like activity (NSILA) from human serum: Recent accomplishments and their physiologic implications

1978 • 246 citations

Effects of Autoantibodies to the Insulin Receptor on Isolated Adipocytes

1977 • 244 citations

Insulin receptor: covalent labeling and identification of subunits.

1979 • 243 citations

Binding and uptake of 125I-insulin into rat liver hepatocytes and endothelium. An in vivo radioautographic study.

1979 • 223 citations

Pyruvate Dehydrogenase Activation in Adipocyte Mitochondria by an Insulin-Generated Mediator from Muscle

1979 • 222 citations

Antibodies to Purified Insulin Receptor Have Insulin-Like Activity

1978 • 222 citations

Photoaffinity labeling of insulin receptor of rat adiopocyte plasma membrane.

1978 • 216 citations

Activation of adenylate cyclase in hepatic membranes involves interactions of the catalytic unit with multimeric complexes of regulatory proteins.

1979 • 211 citations

Proinsulin and the Biosynthesis of Insulin

1969 • 208 citations

Internalization of polypeptide hormones

1980 • 207 citations

Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man.

1976 • 206 citations

Insulin binding to the human lymphocyte receptor. Evaluation of the negative cooperativity model.

1977 • 205 citations

Photoaffinity labeling of insulin receptor proteins of liver plasma membrane preparations

1980 • 195 citations

The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing.

1978 • 189 citations

Purification and properties of insulin receptors from rat liver membranes

1977 • 188 citations

Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.

1979 • 185 citations

Binding and receptor-mediated degradation of insulin in adipocytes

1978 • 180 citations

Down Regulation of Insulin Receptors in Primary Cultures of Adult Rat Hepatocytes in Monolayer*

1978 • 178 citations

Extreme Insulin Resistance in Ataxia Telangiectasia

1978 • 177 citations

Actions of insulin in fat cells. Effects of low temperature, uncouplers of oxidative phosphorylation, and respiratory inhibitors.

1977 • 175 citations

Receptors for Insulin, NSILA-s, and Growth Hormone: Applications to Disease States in Man

1975 • 174 citations

Activation of pyruvate dehydrogenase by direct addition of insulin to an isolated plasma membrane/mitochondria mixture: Evidence for generation of insulin's second messenger in a subcellular system

1980 • 172 citations

Insulin Today

1977 • 172 citations

The Insulin Receptor in Vertebrates Is Functionally More Conserved during Evolution than Insulin Itself

1979 • 164 citations

Internalization and degradation of fat cell-bound insulin. Separation and partial characterization of subcellular vesicles associated with iodoinsulin.

1979 • 161 citations

Regulation of Insulin Receptors and Insulin Responsiveness in 3T3-L1 Fatty Fibroblasts

1979 • 147 citations

On the Physiology of the Salivary Secretion

1878 • 145 citations

The subunit structure of rat liver insulin receptor. Antibodies directed against the insulin-binding subunit.

1980 • 144 citations

Activation of glycogen synthase in rat adipocytes by insulin and glucose involves increased glucose transport and phosphorylation.

1978 • 142 citations

Entry of Insulin Into Human Cultured Lymphocytes: Electron Microscope Autoradiographic Analysis

1978 • 135 citations

Biochemical Actions of Hormones

1978 • 135 citations

Correlation Among Insulin Binding, Degradation, and Biological Activity in Human Breast Cancer Cells in Long-Term Tissue Culture

1978 • 132 citations

Characterization of the insulin receptor in its membrane environment by radiation inactivation.

1980 • 131 citations

DNA Synthesis in Human Fibroblasts: Stimulation by Insulin and by Nonsuppressible Insulin-like Activity (NSILA-S)

1974 • 122 citations

Exchange of partners in glucagon receptor-adenylate cyclase complexes. Physical evidence for the independent, mobile receptor model

1977 • 113 citations

Photoreactive insulin analogues used to characterise the insulin receptor

1980 • 101 citations

Triggering of Cultured Neoplastic Mast Cells by Antibodies to the Receptor for IgE

1978 • 101 citations

Insulin resistance due to a defect distal to the insulin receptor: Demonstration in a patient with leprechaunism

1978 • 101 citations

Insulin receptor: Interaction with nonreceptor glycoprotein from liver cell membranes

1978 • 100 citations

Insulin and non-suppressible insulin-like activity (NSILA-s): Evidence for separate plasma membrane receptor sites

1974 • 99 citations

Modulation of binding and bioactivity of insulin by anti-insulin antibody: relation to possible role of receptor self-aggregation in hormone action.

1979 • 99 citations

Immunoprecipitation of the Insulin Receptor: A Sensitive Assay for Receptor Antibodies and a Specific Technique for Receptor Purification*

1979 • 97 citations

Receptors for Peptide Hormones

1977 • 97 citations

Insulin-induced dissociation of its receptor into subunits: Possible molecular concomitant of negative cooperativity

1976 • 96 citations

Insulin stimulation of pyruvate dehydrogenase in an isolated plasma membrane-mitochondrial mixture occurs by activation of pyruvate dehydrogenase phosphatase.

1980 • 95 citations

Mode of uptake and degradation of ¹²⁵I-labelled insulin by isolated hepatocytes and H4 hepatoma cells

1979 • 94 citations

Stimulation of glucose metabolism by lectins in isolated white fat cells

1973 • 93 citations

Insulin-dependent regulation of the insulin-sensitivity of adipocytes

1978 • 86 citations

Primary defect of insulin receptors in skin fibroblasts cultured from an infant with leprechaunism and insulin resistance.

1979 • 82 citations

Insulin-receptor antibodies mimic a late insulin effect

1979 • 77 citations

Insulin binding to solubilized material from fat cell membranes: Evidence for two binding species

1978 • 75 citations

Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor.

1976 • 74 citations

THE QUANTITATIVE RELATION BETWEEN INSULIN AND ITS BIOLOGICAL ACTIVITY

1953 • 71 citations

Characterization of insulin receptors in patients with the syndromes of insulin resistance and acanthosis nigricans

1980 • 69 citations

Autoantibodies to the Insulin Receptor

1977 • 69 citations

Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle

1978 • 67 citations

Does Insulin Need a Second Messenger?

1977 • 66 citations

Lack of Specificity of Insulin-I131-Binding by Isolated Rat Diaphragm

1957 • 62 citations

Subunit structure of the insulin receptor of the human lymphocyte

1980 • 61 citations

Desensitization of the insulin receptor at an early postreceptor step by prolonged exposure to antireceptor antibody

1979 • 59 citations

Multiple Redox Forms of the Insulin Receptor in Native Liver Membranes

1980 • 58 citations

Insulin and antibodies against insulin receptor cap on the membrane of cultured human lymphocytes

1980 • 54 citations

Effects of Antiinsulin Receptor Autoantibody on the Metabolism of Rat Adipocytes

1978 • 48 citations

DEMONSTRATION OF A PRIMARY (? GENETIC) DEFECT IN INSULIN RECEPTORS IN FIBROBLASTS FROM A PATIENT WITH THE SYNDROME OF INSULIN RESISTANCE AND ACANTHOSIS NIGRICANS TYPE A

1980 • 44 citations

Proinsulin Binds to a Growth Peptide Receptor and Stimulates DNA Synthesis in Chick Embryo Fibroblasts¹

1977 • 44 citations

Antibody-induced Desensitization of the Insulin Receptor

1980 • 43 citations

Anti-insulin receptor antibodies mimic the effects of insulin on the activities of pyruvate dehydrogenase and acetylCoA carboxylase and on specific protein phosphorylation in rat epididymal fat cells

1980 • 42 citations

Characterization of the Insulin Receptor and Insulin-Degrading Activity from Human Lymphocytes by Quantitative Polyacrylamide Gel Electrophoresis*

1980 • 41 citations

Cell Membrane Receptors for Polypeptide Hormones: Applications to the Study of Disease States in Mice and Men

1975 • 40 citations

Insulin stimulation of amino acid transport in isolated rat hepatocytes is independent of hormone internalization

1979 • 39 citations

Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes

1978 • 37 citations

Insulin-Stimulated Glucose Uptake by Subcellular Particles from Adipose Tissue Cells

1970 • 37 citations

Preparation of solubilized insulin receptors from human lymphocytes

1972 • 35 citations

The Underlying Insulin Receptor in Patients with Antireceptor Autoantibodies: Demonstration of Normal Binding and Immunological Properties

1979 • 32 citations

Effects of insulin on insulin-binding components extracted from rat fat cell membranes

1979 • 26 citations

Effects of Anti-insulin Receptor Autoantibodies on the Metabolism of Human Adipocytes

1978 • 26 citations

A possible mechanism for insulin resistance and hyperglycaemia in NZO mice

1979 • 25 citations

Biological properties of antibodies against rat adipocyte intrinsic membrane proteins. Dependence on multivalency for insulin-like activity.

1979 • 25 citations

Genetics of cell-surface receptors for bioactive polypeptides: A variant of mouse BALBc/3T3 fibroblasts possessing altered insulin-binding ability

1980 • 25 citations

Stimulation by insulin of cyclic AMP phosphodiesterase. role of glutathione-insulin transhydrogenase

1977 • 13 citations