Expression and function of IRS-1 in insulin signal transmission.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

PCR protocols — A guide to methods and applications

1990 • 10,078 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

Insulin Resistance — Mechanisms, Syndromes, and Implications

1991 • 788 citations

After Insulin Binds

1987 • 687 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

The insulin receptor and the molecular mechanism of insulin action.

1988 • 426 citations

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1988 • 368 citations

A Phosphatidylinositol-3 Kinase Binds to Platelet-Derived Growth Factor Receptors through a Specific Receptor Sequence Containing Phosphotyrosine

1991 • 294 citations

Mutations in Insulin-Receptor Gene in Insulin-Resistant Patients

1990 • 207 citations

Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase

1991 • 198 citations

Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell.

1987 • 195 citations

Two dominant-acting selectable markers for gene transfer studies in mammalian cells.

1988 • 184 citations

Insulin-activated tyrosine phosphorylation of a 15-kilodalton protein in intact 3T3-L1 adipocytes.

1987 • 181 citations

YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase.

1992 • 170 citations

High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.

1987 • 151 citations

Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.

1992 • 148 citations

Characterization of an endogenous substrate of the insulin receptor in cultured cells.

1987 • 136 citations

Phosphorylation and dephosphorylation of the insulin receptor: evidence against an intrinsic phosphatase activity

1984 • 122 citations

The glucose transporter in 3T3-L1 adipocytes is phosphorylated in response to phorbol ester but not in response to insulin.

1986 • 121 citations

Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells.

1987 • 120 citations

Hepatocyte plasma membrane ecto-ATPase (pp120HA4) is a substrate for tyrosine kinase activity of the insulin receptor

1990 • 108 citations

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.

1990 • 107 citations

Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma

1994 • 101 citations

Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells.

1987 • 97 citations

The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus

1991 • 90 citations

Insulin receptors with defective tyrosine kinase inhibit normal receptor function at the level of substrate phosphorylation.

1988 • 82 citations

Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro.

1992 • 79 citations

Insulin-induced tyrosine-phosphorylation in intact rat adipocytes

1988 • 57 citations

Mutations in the Juxtamembrane Region of the Insulin Receptor Impair Activation of Phosphatidylinositol 3-Kinase by Insulin

1991 • 49 citations

Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells

1991 • 39 citations

Immunological Detection of Phosphotyrosine-Containing Proteins in Rat Livers After Insulin Injection

1990 • 35 citations

Human Insulin Receptors Expressed in Insulin-Insensitive Mouse Fibroblasts Couple with Extant Cellular Effector Systems to Confer Insulin Sensitivity and Responsiveness*

1989 • 26 citations

Comparison of the phosphorylation events in membranes from proliferating vs. quiescent endothelial cells

1987 • 8 citations