Hypothalamic control of energy balance: different peptides, different functions

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

Central nervous system control of food intake

2000 • 6,305 citations

Ghrelin induces adiposity in rodents

2000 • 3,915 citations

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

1998 • 3,711 citations

A role for ghrelin in the central regulation of feeding

2001 • 3,415 citations

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

1998 • 3,381 citations

Narcolepsy in orexin Knockout Mice

1999 • 3,014 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans

2001 • 2,865 citations

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

1999 • 2,583 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide

1982 • 2,244 citations

Circulating Ghrelin Levels Are Decreased in Human Obesity

2001 • 1,999 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

2003 • 1,617 citations

The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion

2000 • 1,521 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Galanin — a novel biologically active peptide from porcine intestine

1983 • 1,480 citations

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

1995 • 1,469 citations

Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*

1999 • 1,467 citations

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

2001 • 1,387 citations

Neuropeptide Y: complete amino acid sequence of the brain peptide.

1982 • 1,360 citations

A role for melanin-concentrating hormone in the central regulation of feeding behaviour

1996 • 1,301 citations

Hypothalamic CART is a new anorectic peptide regulated by leptin

1998 • 1,283 citations

NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS

1984 • 1,274 citations

Orexin A activates locus coeruleus cell firing and increases arousal in the rat

1999 • 1,182 citations

Mice lacking melanin-concentrating hormone are hypophagic and lean

1998 • 1,139 citations

Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues

1997 • 1,137 citations

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

1998 • 1,136 citations

Ghrelin Causes Hyperphagia and Obesity in Rats

2001 • 1,121 citations

The Need to Feed

2002 • 1,089 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

1994 • 1,059 citations

Distribution of orexin neurons in the adult rat brain

1999 • 1,052 citations

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

1999 • 1,028 citations

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

1996 • 1,020 citations

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

1999 • 1,000 citations

Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors

2000 • 983 citations

Distribution of orexin receptor mRNA in the rat brain

1998 • 982 citations

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

2001 • 911 citations

Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

1999 • 909 citations

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

2000 • 896 citations

Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice

2003 • 892 citations

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

2000 • 878 citations

Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors

2001 • 877 citations

Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight

1999 • 862 citations

Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

2001 • 862 citations

Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity

1986 • 856 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

1998 • 817 citations

Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

1996 • 814 citations

The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice

1998 • 802 citations

Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

1998 • 797 citations

Molecular characterization of the mouse agouti locus

1992 • 791 citations

To Eat or to Sleep? Orexin in the Regulation of Feeding and Wakefulness

2001 • 754 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 731 citations

Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.

1993 • 719 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

1994 • 703 citations

Hypocretin/Orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems

1998 • 687 citations

A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

2000 • 677 citations

PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine

1995 • 656 citations

Malonyl-CoA, fuel sensing, and insulin resistance

1999 • 655 citations

Altered Expression of Hypothalamic Neuropeptide mRNAs in Food-Restricted and Food-Deprived Rats

1990 • 648 citations

Upregulation of Ghrelin Expression in the Stomach upon Fasting, Insulin-Induced Hypoglycemia, and Leptin Administration

2001 • 629 citations

Handbook of obesity

1997 • 629 citations

Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice

2003 • 629 citations

Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance

2001 • 617 citations

Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2

2000 • 591 citations

Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system

1993 • 577 citations

The hypothalamus and the control of energy homeostasis

2001 • 567 citations

Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide

1996 • 561 citations

A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormonein Vivo

1998 • 555 citations

Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides

1999 • 549 citations

Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism

2002 • 547 citations

Molecular characterization of the melanin-concentrating-hormone receptor

1999 • 541 citations

Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need

1995 • 525 citations

Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations

1999 • 502 citations

Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1

1999 • 495 citations

Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss

1999 • 487 citations

Activation of Central Melanocortin Pathways by Fenfluramine

2002 • 481 citations

Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway

2003 • 458 citations

Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord

2001 • 457 citations

The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion

2000 • 454 citations

Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy

2001 • 443 citations

Fluctuation of extracellular hypocretin‐1 (orexin A) levels in the rat in relation to the light–dark cycle and sleep–wake activities

2001 • 441 citations

Several Mutations in the Melanocortin-4 Receptor Gene Including a Nonsense and a Frameshift Mutation Associated with Dominantly Inherited Obesity in Humans

1999 • 439 citations

Sympathetic and cardiovascular actions of orexins in conscious rats

1999 • 439 citations

The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin

1999 • 438 citations

Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities

2003 • 427 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

Characterization of CART neurons in the rat and human hypothalamus

2001 • 421 citations

Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice

2002 • 421 citations

Acute Central Ghrelin and GH Secretagogues Induce Feeding and Activate Brain Appetite Centers

2002 • 420 citations

Role of the Y5 neuropeptide Y receptor in feeding and obesity

1998 • 419 citations

Melanin-Concentrating Hormone Acutely Stimulates Feeding, But Chronic Administration Has No Effect on Body Weight

1997 • 416 citations

The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins

2002 • 406 citations

The lateral hypothalamic area revisited: Ingestive behavior

1996 • 400 citations

Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight

1999 • 398 citations

Neural mechanisms in human obesity-related hypertension

1999 • 394 citations

Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor

1998 • 391 citations

Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion

1985 • 386 citations

CART peptides in the central control of feeding and interactions with neuropeptide Y

1998 • 379 citations

Immunohistochemical Localization of Novel CART Peptides in Rat Hypothalamus, Pituitary and Adrenal Gland

1997 • 379 citations

AgRP(83–132) Acts as an Inverse Agonist on the Human-Melanocortin-4 Receptor

2001 • 375 citations

Hypothalamic Agouti-Related Protein Messenger Ribonucleic Acid Is Inhibited by Leptin and Stimulated by Fasting*

1999 • 374 citations

Transgenic Mice Expressing Green Fluorescent Protein under the Control of the Melanocortin-4 Receptor Promoter

2003 • 362 citations

Effect of Intracerebroventricular Insulin Infusion on Diabetic Hyperphagia and Hypothalamic Neuropeptide Gene Expression

1995 • 361 citations

Anatomy and physiology of central galanin-containing pathways

1993 • 340 citations

The Biology of Neuropeptide Y and Related Peptides

1993 • 339 citations

Model for the regulation of energy balance and adiposity by the central nervous system

1999 • 339 citations

Central melanocortin receptors regulate insulin action

2001 • 335 citations

Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat

2001 • 332 citations

Feeding and body-weight regulation by hypothalamic neuropeptides—mediation of the actions of leptin

1999 • 330 citations

Peripheral ghrelin selectively increases Fos expression in neuropeptide Y – synthesizing neurons in mouse hypothalamic arcuate nucleus

2002 • 330 citations

Independent Feeding and Metabolic Actions of Orexins in Mice

1998 • 325 citations

Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats

1999 • 320 citations

Long-term orexigenic effects of AgRP-(83—132) involve mechanisms other than melanocortin receptor blockade

2000 • 318 citations

Central melanocortin receptors regulate insulin action

2001 • 317 citations

Feeding response to central orexins

1999 • 316 citations

Targeted Disruption of the Melanin-Concentrating Hormone Receptor-1 Results in Hyperphagia and Resistance to Diet-Induced Obesity

2002 • 314 citations

Hypothalamic orexin expression: modulation by blood glucose and feeding.

1999 • 313 citations

Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat

1999 • 309 citations

The distribution of the mRNA and protein products of the melanin‐concentrating hormone (MCH) receptor gene, slc‐1, in the central nervous system of the rat

2000 • 304 citations

Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism

1994 • 303 citations

CRF antagonist partially reverses CRF- and stress-induced effects on feeding

1986 • 302 citations

Cardiovascular regulatory actions of the hypocretins in brain

1999 • 299 citations

Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.

1995 • 290 citations

Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect

1992 • 288 citations

The central distribution of a corticotropin-releasing factor (CRF)-binding protein predicts multiple sites and modes of interaction with CRF.

1992 • 288 citations

Behavioral characterization of neuropeptide Y knockout mice

2000 • 287 citations

Role of the central melanocortin system in cachexia.

2001 • 286 citations

Neuropeptides, food intake and body weight regulation: a hypothalamic focus

2002 • 283 citations

Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression

2002 • 282 citations

Galanin: Stimulation of feeding induced by medial hypothalamic injection of this novel peptide

1986 • 280 citations

Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia

1999 • 274 citations

Neuropeptide Y suppresses sympathetic activity to interscapular brown adipose tissue in rats

1991 • 274 citations

Isolation and cDNA Cloning of a Novel Galanin-like Peptide (GALP) from Porcine Hypothalamus

1999 • 273 citations

Behavioral effects of corticotropin-releasing factor: localization and characterization of central effects

1988 • 267 citations

Reduced central leptin sensitivity in rats with diet-induced obesity

2002 • 266 citations

Orexin-induced food intake involves neuropeptide Y pathway

2000 • 262 citations

Effects of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats

1988 • 255 citations

Hypothalamic cocaine- and amphetamine-regulated transcript (CART) neurons: histochemical relationship to thyrotropin-releasing hormone, melanin-concentrating hormone, orexin/hypocretin and neuropeptide Y

1999 • 255 citations

Effects of PVN galanin on macronutrient selection

1988 • 252 citations

Distinct Physiologic and Neuronal Responses to Decreased Leptin and Mild Hyperleptinemia¹

1999 • 250 citations

Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor

2001 • 248 citations

Life without neuropeptide Y.

1998 • 244 citations

Evidence Suggesting That Galanin (GAL), Melanin-Concentrating Hormone (MCH), Neurotensin (NT), Proopiomelanocortin (POMC) and Neuropeptide Y (NPY) Are Targets of Leptin Signaling in the Hypothalamus

1998 • 241 citations

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice.

2000 • 240 citations

Urocortin III-Immunoreactive Projections in Rat Brain: Partial Overlap with Sites of Type 2 Corticotrophin-Releasing Factor Receptor Expression

2002 • 240 citations

Corticotropin Releasing Factor (CRF) Binding Protein: A Novel Regulator of CRF and Related Peptides

1995 • 239 citations

Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype

2003 • 237 citations

Short communication

1998 • 233 citations

Monitoring of stored and available fuel by the CNS: implications for obesity

2003 • 231 citations

Leptin and Insulin Action in the Central Nervous System

2002 • 231 citations

Characterization of Melanin-Concentrating Hormone from Rat Hypothalamus*

1989 • 228 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 226 citations

Leptin Receptor‐ and STAT3‐Immunoreactivities in Hypocretin/Orexin Neurones of the Lateral Hypothalamus¹

1999 • 226 citations

Interaction between α-Melanocyte-Stimulating Hormone and Corticotropin-Releasing Hormone in the Regulation of Feeding and Hypothalamo-Pituitary-Adrenal Responses

2003 • 225 citations

Lateral hypothalamic neuropeptides in reward and drug addiction

2003 • 223 citations

Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice

2000 • 223 citations

Adiposity signals and the control of energy homeostasis

2000 • 222 citations

Minireview: Nutrient Sensing and the Regulation of Insulin Action and Energy Balance

2003 • 217 citations

Neuropeptide Y, epinephrine and norepinephrine in the paraventricular nucleus: Stimulation of feeding and the release of corticosterone, vasopressin and glucose

1988 • 217 citations

Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice

1998 • 217 citations

ART (Protein Product of Agouti-Related Transcript) as an Antagonist of MC-3 and MC-4 Receptors

1997 • 217 citations

Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord☆

1999 • 217 citations

Delayed Short-Term Secretory Regulation of Ghrelin in Obese Animals: Evidenced by a Specific RIA for the Active Form of Ghrelin

2002 • 215 citations

The hypothalamus and the regulation of energy homeostasis: lifting the lid on a black box

2000 • 212 citations

Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression

2003 • 212 citations

Hypoglycemia Activates Orexin Neurons and Selectively Increases Hypothalamic Orexin-B Levels

2001 • 211 citations

Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity

2002 • 210 citations

Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y

1993 • 209 citations

Adrenal Steroid Receptors: Interactions with Brain Neuropeptide Systems in Relation to Nutrient Intake and Metabolism

1994 • 209 citations

Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats

2000 • 207 citations

Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus

1997 • 206 citations

Characterization of the human cDNA and genomic DNA encoding CART: a cocaine- and amphetamine-regulated transcript

1996 • 205 citations

Chronic intracerebroventricular infusion of MCH causes obesity in mice

2003 • 204 citations

The corticotropin-releasing factor family of peptides and CRF receptors: their roles in the regulation of energy balance

2002 • 203 citations

Physiological and Anatomical Circuitry between Agouti-Related Protein and Leptin Signaling*

1999 • 202 citations

AgRP(83-132) Acts as an Inverse Agonist on the Human-Melanocortin-4 Receptor

2001 • 197 citations

Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y

1999 • 195 citations

Central effects of CRF on metabolism and energy balance

1990 • 192 citations

Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague–Dawley rats

2002 • 191 citations

Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin.

1998 • 187 citations

Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides

2001 • 187 citations

Insulin-induced hypoglycemia increases preprohypocretin (orexin) mRNA in the rat lateral hypothalamic area

1999 • 186 citations

Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats

2003 • 185 citations

Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides suppresses feeding behavior and insulin secretion

1994 • 180 citations

Separate systems for serotonin and leptin in appetite control

2000 • 179 citations

Distribution and quantification of immunoreactive orexin A in rat tissues

1999 • 177 citations

Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action.

1999 • 176 citations

Ghrelin and Leptin Pulse Discharge in Fed and Fasted Rats

2002 • 174 citations

Endorphinergic and α-noradrenergic systems in the paraventricular nucleus: Effects on eating behavior

1982 • 172 citations

Leptin Sensitive Neurons in the Hypothalamus

1999 • 172 citations

Characterization of MCH-mediated obesity in mice

2003 • 171 citations

Neural and Metabolic Control of Macronutrient Intake

1999 • 170 citations

Absence of Cocaine- and Amphetamine-Regulated Transcript Results in Obesity in Mice Fed a High Caloric Diet

2001 • 167 citations

Human eating: Evidence for a physiological basis using a modified paradigm

1996 • 164 citations

Localization of glucokinase gene expression in the rat brain.

2000 • 164 citations

A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormone in Vivo

1998 • 163 citations

Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats

2000 • 161 citations

Central Administration of Cocaine-Amphetamine-Regulated Transcript Activates Hypothalamic Neuroendocrine Neurons in the Rat

2000 • 160 citations

Immunotoxin Lesion of Hypothalamically Projecting Norepinephrine and Epinephrine Neurons Differentially Affects Circadian and Stressor-Stimulated Corticosterone Secretion

2003 • 159 citations

Transgenic approach to the study of body weight regulation.

2000 • 158 citations

Evidence of an Orexigenic Role for Cocaine- and Amphetamine-Regulated Transcript after Administration into Discrete Hypothalamic Nuclei

2001 • 157 citations

Down regulation of the prepro-orexin gene expression in genetically obese mice

1999 • 156 citations

Integrated control of appetite and fat metabolism by the leptin-proopiomelanocortin pathway

2001 • 156 citations

Sugars and Fats: The Neurobiology of Preference

2003 • 154 citations

Eating Elicited by Orexin-A, But Not Melanin-Concentrating Hormone, Is Opioid Mediated

2002 • 154 citations

Palatability-induced hyperphagia increases hypothalamic Dynorphin peptide and mRNA levels

1996 • 153 citations

Reciprocal relation of food intake and sympathetic activity: experimental observations and clinical implications

2000 • 153 citations

Ghrelin Stimulates GH But Not Food Intake in Arcuate Nucleus Ablated Rats

2002 • 153 citations

Effects of adrenalectomy on AGRP, POMC, NPY and CART gene expression in the basal hypothalamus of fed and fasted rats

2002 • 152 citations

Effects of Chronic Central Nervous System Administration of Agouti-Related Protein in Pair-Fed Animals

2001 • 152 citations

Widespread Distribution of Orexin in Rat Brain and Its Regulation upon Fasting

1999 • 152 citations

GH-Releasing Peptide-2 Increases Fat Mass in Mice Lacking NPY: Indication for a Crucial Mediating Role of Hypothalamic Agouti-Related Protein

2002 • 151 citations

Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice

1999 • 151 citations

Increased Frequency of Non-Insulin-Dependent Diabetes Mellitus Among Narcoleptic Patients

1986 • 150 citations

Obesity on a High-Fat Diet: Role of Hypothalamic Galanin in Neurons of the Anterior Paraventricular Nucleus Projecting to the Median Eminence

1998 • 150 citations

Diverse functions of neuropeptide Y revealed using genetically modified animals

2002 • 150 citations

The role of galanin in feeding behavior

1999 • 149 citations

Melanin-Concentrating Hormone Acutely Stimulates Feeding, But Chronic Administration Has No Effect on Body Weight

1997 • 148 citations

Distribution of Galanin-Like Peptide in the Rat Brain

2001 • 147 citations

A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

2000 • 147 citations

Galanin-containing neurons in the paraventricular nucleus: a neurochemical marker for fat ingestion and body weight gain.

1994 • 147 citations

The melanin-concentrating hormone: from the peptide to the gene.

1994 • 147 citations

Acute Central Ghrelin and GH Secretagogues Induce Feeding and Activate Brain Appetite Centers

2002 • 146 citations

Repeated hypothalamic stimulation with neuropeptide Y increases daily carbohydrate and fat intake and body weight gain in female rats

1989 • 145 citations

Galanin-Like Peptide (GALP) Is a Target for Regulation by Leptin in the Hypothalamus of the Rat

2000 • 143 citations

Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism

2001 • 143 citations

Postnatal regulation of hypothalamic neuropeptide expression by leptin: implications for energy balance and body weight regulation

2000 • 143 citations

Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus

2003 • 140 citations

Effects of CART peptides on food consumption, feeding and associated behaviors in the goldfish, Carassius auratus: actions on neuropeptide Y- and orexin A-induced feeding

2000 • 139 citations

Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats

2003 • 139 citations

Altered Expression of Agouti-Related Protein and Its Colocalization with Neuropeptide Y in the Arcuate Nucleus of the Hypothalamus during Lactation*

1999 • 138 citations

Diabetes and the hypothalamo-pituitary-adrenal (HPA) axis.

2003 • 136 citations

Blood Glucose Dynamics and Control of Meal Initiation: A Pattern Detection and Recognition Theory

2003 • 136 citations

The role of CRF2 receptors in corticotropin-releasing factor-and urocortin-induced anorexia

1998 • 135 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 134 citations

Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet-induced obese rats

1997 • 133 citations

Melanin-Concentrating Hormone Receptor Is a Target of Leptin Action in the Mouse Brain

2001 • 132 citations

Differential Role of Melanocortin Receptor Subtypes in Cachexia

2003 • 132 citations

Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats

1999 • 132 citations

Ghrelin, Macronutrient Intake and Dietary Preferences in Long–Evans Rats

2002 • 131 citations

Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats.

2000 • 130 citations

Effects of Recombinant Agouti-Signaling Protein on Melanocortin Action

1997 • 130 citations

A malonyl-CoA fuel-sensing mechanism in muscle: effects of insulin, glucose, and denervation

1995 • 130 citations

Targeted Disruption of the Melanin-Concentrating Hormone Receptor-1 Results in Hyperphagia and Resistance to Diet-Induced Obesity

2002 • 129 citations

A Role for Galanin-Like Peptide in the Integration of Feeding, Body Weight Regulation, and Reproduction in the Mouse

2003 • 129 citations

Galanin Antagonists Block Galanin‐induced Feeding in the Hypothalamus and Amygdala of the Rat

1993 • 129 citations

Hypothalamic Agouti-Related Protein Messenger Ribonucleic Acid Is Inhibited by Leptin and Stimulated by Fasting

1999 • 128 citations

Neuropeptide Y projection from arcuate nucleus to parvocellular division of paraventricular nucleus: specific relation to the ingestion of carbohydrate

1993 • 126 citations

Hypothalamic Circuitry of Neuropeptide Y Regulation of Neuroendocrine Function and Food Intake via the Y5 Receptor Subtype

2001 • 125 citations

Corticotropin Releasing Factor mRNA Expression in the Hypothalamic Paraventricular Nucleus and the Central Nucleus of the Amygdala is Modulated by Repeated Acute Stress in the Immature Rat

1998 • 125 citations

Circulating Triglycerides Impact on Orexigenic Peptides and Neuronal Activity in Hypothalamus

2004 • 124 citations

Identification of Hypothalamic Nuclei Involved in the Orexigenic Effect of Melanin-Concentrating Hormone

2003 • 124 citations

Effect of 2-mercaptoacetate and 2-deoxy-D-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamus

2000 • 121 citations

Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: a novel circuit implicated in feeding regulation

2002 • 121 citations

Hypothalamic levels of NPY, MCH, and prepro‐orexin mRNA during pregnancy and lactation in the rat: role of prolactin

2003 • 120 citations

Several Mutations in the Melanocortin-4 Receptor Gene Including a Nonsense and a Frameshift Mutation Associated with Dominantly Inherited Obesity in Humans

1999 • 120 citations

Brain Peptides and Obesity: Pharmacologic Treatment

1995 • 119 citations

Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity

2003 • 119 citations

Orexin gene expression is increased during states of hypertriglyceridemia

2003 • 119 citations

Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues

1999 • 118 citations

Preference and diet type affect macronutrient selection after morphine, NPY, norepinephrine, and deprivation

1994 • 116 citations

A role for arcuate cocaine and amphetamine regulated transcript in hyperphagia, thermogenesis, and cold adaptation

2003 • 115 citations

Diurnal variations in the feeding responses to norepinephrine, neuropeptide Y and galanin in the PVN

1990 • 115 citations

Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression

1995 • 115 citations

Different forms of obesity as a function of diet composition

2005 • 113 citations

Paraventricular hypothalamic α-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive effects

2001 • 112 citations

Impact of a galanin antagonist on exogenous galanin and natural patterns of fat ingestion

1992 • 112 citations

Independent and Overlapping Effects of Corticosterone and Testosterone on Corticotropin-Releasing Hormone and Arginine Vasopressin mRNA Expression in the Paraventricular Nucleus of the Hypothalamus and Stress-Induced Adrenocorticotropic Hormone Release

1999 • 111 citations

Neuropeptide Y and energy homeostasis: insights from Y receptor knockout models

2003 • 110 citations

Neuropeptide Y: A Physiological Orexigen Modulated by the Feedback Action of Ghrelin and Leptin

2003 • 109 citations

Galanin-Like Peptide (GALP) mRNA Expression Is Restricted to Arcuate Nucleus of Hypothalamus in Adult Male Rat Brain

2000 • 108 citations

Neuropeptide Y in Multiple Hypothalamic Sites Controls Eating Behavior, Endocrine, and Autonomic Systems for Body Energy Balance

1993 • 108 citations

Synergistic Effects of Y2 and Y4 Receptors on Adiposity and Bone Mass Revealed in Double Knockout Mice

2003 • 108 citations

Effect of corticotropin releasing hormone and neuropeptide Y on electrophysiological activity of sympathetic nerves to interscapular brown adipose tissue

1990 • 106 citations

Centrally Administered Galanin‐Like Peptide Modifies Food Intake in the Rat: A Comparison with Galanin

2002 • 105 citations

Glucocorticoids and neuroendocrine function

2000 • 104 citations

The corticotropin-releasing hormone system in the regulation of energy balance in obesity

2000 • 103 citations

Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice.

2000 • 103 citations

Melanin-concentrating hormone: from fish skin to skinny mammals

2003 • 102 citations

Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression

2000 • 101 citations

Urocortin, Corticotropin Releasing Factor-2 Receptors and Energy Balance

2001 • 100 citations

Obesity: molecular bases of a multifactorial problem

2000 • 99 citations

Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds

1991 • 99 citations

New model for the regulation of energy balance and adiposity by the central nervous system

1995 • 98 citations

Melanocortin‐3 Receptor mRNA Expression in Pro‐Opiomelanocortin Neurones of the Rat Arcuate Nucleus

2000 • 97 citations

Cocaine-Amphetamine-Regulated Transcript (CART) Acts in the Central Nervous System to Inhibit Gastric Acid Secretion via Brain Corticotropin-Releasing Factor System*

2000 • 96 citations

Neuropeptide Y in Central Control

2001 • 96 citations

Suppression of neuropeptide Y-elicited eating by adrenalectomy or hypophysectomy: reversal with corticosterone

1989 • 96 citations

Central insulin inhibits hypothalamic galanin and neuropeptide Y gene expression and peptide release in intact rats

1997 • 96 citations

Chronic CNS administration of Agouti-related protein (Agrp) reduces energy expenditure

2003 • 96 citations

Hypothalamic Neuropeptide Y and Its Gene Expression: Relation to Light/Dark Cycle and Circulating Corticosterone

1994 • 95 citations

Adrenalectomy Prevents the Obesity Syndrome Produced by Chronic Central Neuropeptide Y Infusion in Normal Rats

1997 • 95 citations

Excess corticotropin releasing hormone-binding protein in the hypothalamic-pituitary-adrenal axis in transgenic mice.

1998 • 94 citations

Self-selecting albino rats exhibit differential preferences for pure macronutrient diets: Characterization of three subpopulations

1991 • 94 citations

Metabolic effects of neuropeptide Y injections into the paraventricular nucleus of the hypothalamus

1990 • 94 citations

Distribution and Regulation of Galanin-Like Peptide (GALP) in the Hypothalamus of the Mouse

2001 • 93 citations

Investigation of the feeding effects of melanin concentrating hormone on food intake — action independent of galanin and the melanocortin receptors

1999 • 93 citations

Chronic cerebroventricular galanin does not induce sustained hyperphagia or obesity

1994 • 93 citations

Hypothalamic Hypocretin/Orexin and Neuropeptide Y: Divergent Interaction with Energy Depletion and Leptin

1999 • 93 citations

Central Pro-opiomelanocortin Gene Delivery Results in Hypophagia, Reduced Visceral Adiposity, and Improved Insulin Sensitivity in Genetically Obese Zucker Rats

2003 • 92 citations

Chronic Intracerebroventricular Administration of Recombinant CART(42–89) Peptide Inhibits Food Intake and Causes Weight Loss in Lean and Obese Zucker (fa/fa) Rats

2000 • 91 citations

Human cocaine- and amphetamine-regulated transcript (CART) mRNA is highly expressed in limbic- and sensory-related brain regions

2000 • 91 citations

Human cocaine‐ and amphetamine‐regulated transcript (CART) mRNA is highly expressed in limbic‐ and sensory‐related brain regions

2000 • 91 citations

The neuropeptide Y Y1 receptor regulates leptin‐mediated control of energy homeostasis and reproductive functions

2002 • 91 citations

Hypothalamic Melanin-Concentrating Hormone and Estrogen-Induced Weight Loss

2000 • 91 citations

Distribution of galanin messenger RNA-expressing cells in murine brain and their regulation by leptin in regions of the hypothalamus

2001 • 90 citations

Mutations in the Human Proopiomelanocortin Gene

2003 • 89 citations

Neuropeptide Y in the arcuate nucleus is modulated by alterations in glucose utilization

1993 • 88 citations

Effect of Direct Injection of Melanin-Concentrating Hormone into the Paraventricular Nucleus: Further Evidence for a Stimulatory Role in the Adrenal Axis via SLC-1

2003 • 88 citations

Modulation of Urocortin-Induced Hypophagia and Weight Loss by Corticotropin-Releasing Factor Receptor 1 Deficiency in Mice*

2000 • 87 citations

Differential Regulation of Melanin-Concentrating Hormone and Orexin Genes in the Agouti-Related Protein/Melanocortin-4 Receptor System

2000 • 87 citations

Hypothalamic neuropeptide Y, its gene expression and receptor activity: relation to circulating corticosterone in adrenalectomized rats

1994 • 87 citations

Diabetes Impairs Hypothalamo-Pituitary-Adrenal (HPA) Responses to Hypoglycemia, and Insulin Treatment Normalizes HPA but not Epinephrine Responses

2002 • 86 citations

Preprohypocretin (orexin) and prolactin-like immunoreactivity are coexpressed by neurons of the rat lateral hypothalamic area

1999 • 86 citations

Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia

1999 • 86 citations

Immediate and Prolonged Patterns of Agouti-Related Peptide-(83–132)-Induced c-Fos Activation in Hypothalamic and Extrahypothalamic Sites*

2001 • 86 citations

Effects of corticotropin releasing hormone on appetitive behaviors

1992 • 86 citations

Diurnal Rhythm of Agouti-Related Protein and Its Relation to Corticosterone and Food Intake

2002 • 85 citations

Developmental patterns of macronutrient intake in female and male rats from weaning to maturity

1991 • 85 citations

Proceedings of the Australian Physiological and Pharmacological Society Symposium: The Hypothalamus DISTRIBUTION, REGULATION AND ROLE OF HYPOTHALAMIC GALANIN SYSTEMS: RENEWED INTEREST IN A PLEIOTROPIC PEPTIDE FAMILY

2001 • 85 citations

Galanin-like peptide stimulates food intake in the rat

2002 • 85 citations

Rat hypothalamic NPY mRNA and brown fat uncoupling protein mRNA after high-carbohydrate or high-fat diets

1994 • 84 citations

Rat melanin-concentrating hormone messenger ribonucleic acid expression: marked changes during development and after stress and glucocorticoid stimuli.

1992 • 84 citations

Acute high-fat diet paradigms link galanin to triglycerides and their transport and metabolism in muscle

2004 • 83 citations

Hypothalamic Melanin-Concentrating Hormone Is Induced by Cold Exposure and Participates in the Control of Energy Expenditure in Rats

2003 • 82 citations

Diurnal and nocturnal rodents show rhythms in orexinergic neurons

2002 • 81 citations

Inverse agonist activity of agouti and agouti-related protein

2003 • 81 citations

Development of the neuronal system containing neuropeptide Y in the rat hypothalamus

1989 • 80 citations

Changes in Hypothalamic Agouti-Related Protein (AGRP), but not α-MSH or Pro-Opiomelanocortin Concentrations in Dietary-Obese and Food-Restricted Rats

1999 • 80 citations

Identification of a biochemical link between energy intake and energy expenditure

2002 • 79 citations

Behavioral, endocrine, and hypothalamic responses to involuntary overfeeding

1996 • 79 citations

Cocaine- and amphetamine-regulated transcript-immunoreactivity in the rat sympatho-adrenal axis

2000 • 78 citations

NPY ablation in C57BL/6 mice leads to mild obesity and to an impaired refeeding response to fasting

2003 • 78 citations

Effects of Treadmill Running on Brain Activation and the Corticotropin-Releasing Hormone System

2003 • 76 citations

Orexin neurons project to diverse sympathetic outflow systems

2003 • 76 citations

Corticotropin-releasing factor-binding protein ligand inhibitor blunts excessive weight gain in genetically obese Zucker rats and rats during nicotine withdrawal

1996 • 76 citations

Attenuation of Diabetic Hyperphagia in Neuropeptide Y–Deficient Mice

2002 • 75 citations

Corticotropin-Releasing Hormone-Mediated Pathway of Leptin to Regulate Feeding, Adiposity, and Uncoupling Protein Expression in Mice

2003 • 75 citations

Agouti-related protein in the hypothalamic paraventricular nucleus: effect on feeding

2000 • 75 citations

Serum leptin concentrations, luteinizing hormone and growth hormone secretion during feed and metabolic fuel restriction in the prepuberal gilt

2001 • 74 citations

ARC POMC mRNA and PVN α-MSH are lower in obese relative to lean Zucker rats

2000 • 74 citations

Dose-Dependent Effects of Central Leptin Gene Therapy on Genes That Regulate Body Weight and Appetite in the Hypothalamus

2001 • 74 citations

Effects of Leptin and Corticosterone on the Expression of Corticotropin-Releasing Hormone, Agouti-Related Protein, and Proopiomelanocortin in the Brain of <i>ob/ob</i> Mouse

2001 • 74 citations

Modest Overexpression of Neuropeptide Y in the Brain Leads to Obesity After High-Sucrose Feeding

2001 • 73 citations

Evidence Suggesting That Galanin (GAL), Melanin-Concentrating Hormone (MCH), Neurotensin (NT), Proopiomelanocortin (POMC) and Neuropeptide Y (NPY) Are Targets of Leptin Signaling in the Hypothalamus

1998 • 73 citations

Corticosterone Infused Intracerebroventricularly Inhibits Energy Storage and Stimulates the Hypothalamo-Pituitary Axis in Adrenalectomized Rats Drinking Sucrose

2002 • 73 citations

Changes in Hypothalamic Expression Levels of Galanin-Like Peptide in Rat and Mouse Models Support That It Is a Leptin-Target Peptide

2003 • 73 citations

Peptide-amine interactions in the hypothalamic paraventricular nucleus: analysis of galanin and neuropeptide Y in relation to feeding

1990 • 73 citations

Distinct Physiologic and Neuronal Responses to Decreased Leptin and Mild Hyperleptinemia

1999 • 73 citations

Orexin/hypocretin neurons: chemical phenotype and possible interactions with melanin-concentrating hormone neurons

2002 • 72 citations

Melanin-Concentrating Hormone (MCH) Suppresses Thyroid Stimulating Hormone (TSH) release, in Vivo and in Vitro, via the Hypothalamus and the Pituitary

2001 • 72 citations

Effect of galanin and enterostatin on sympathetic nerve activity to interscapular brown adipose tissue

1996 • 72 citations

Physiological and Anatomical Circuitry between Agouti-Related Protein and Leptin Signaling

1999 • 71 citations

Hypothalamic galanin: control by signals of fat metabolism

1998 • 71 citations

Reduced Leptin Levels in Human Narcolepsy

2000 • 70 citations

Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice

2003 • 70 citations

Leptin Effects on the Expression of Type‐2 CRH Receptor mRNA in the Ventromedial Hypothalamus in the Rat

1999 • 69 citations

Hypothalamic cocaine-amphetamine regulated transcript (CART) is regulated by glucocorticoids

2003 • 69 citations

Identification of a biochemical link between energy intake and energy expenditure

2002 • 68 citations

Proopiomelanocortin (POMC) products in the central regulation of sympathetic and cardiovascular dynamics: studies on melanocortin and opioid interactions

2000 • 68 citations

Orexinergic innervation of POMC-containing neurons in the rat arcuate nucleus

2001 • 68 citations

Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food intake induced by neuropeptide Y

1993 • 67 citations

Activation of the Sympathetic Nervous System by Galanin-Like Peptide—A Possible Link between Leptin and Metabolism

2003 • 67 citations

Targeted disruption of galanin: new insights from knock-out studies

2002 • 66 citations

Increased Dietary Fat Attenuates the Anorexic Effects of Intracerebroventricular Injections of MTII

2003 • 65 citations

Ectopic Expression of the CRF‐binding Protein: Minor Impact on HPA Axis Regulation but Induction of Sexually Dimorphic Weight Gain

1998 • 64 citations

Effects of Galanin-Like Peptide on Food Intake and the Hypothalamo-Pituitary-Thyroid Axis

2003 • 64 citations

Effects of Neuropeptides and Leptin on Nutrient Partitioning: Dysregulations in Obesity

2001 • 64 citations

α-Melanocyte stimulating hormone prevents fasting-induced suppression of corticotropin-releasing hormone gene expression in the rat hypothalamic paraventricular nucleus

2000 • 64 citations

The Influence of Gonadal Steroids on Pre‐Pro Melanin‐Concentrating Hormone mRNA in Female Rats

2000 • 63 citations

Neuropeptide Y in relation to carbohydrate intake, corticosterone and dietary obesity

1998 • 62 citations

Effect of a high-fat diet on food intake and hypothalamic neuropeptide gene expression in streptozotocin diabetes.

1998 • 62 citations

Differential effects of enterostatin, galanin and opioids on high-fat diet consumption

1995 • 62 citations

Galanin in the hypothalamus of fed and fasted lean and obese Zucker rats

1993 • 62 citations

Fat and Energy Balance

1997 • 61 citations

Glucocorticoid Regulation of Hypothalamic Proopiomelanocortin

1998 • 61 citations

Naloxone reduces the feeding evoked by intracerebroventricular galanin injection

1994 • 60 citations

The MCH receptor family: feeding brain disorders?

2003 • 60 citations

Hypothalamic Neuropeptide Y Messenger Ribonucleic Acid Levels in Pre‐Obese and Genetically Obese (fa/fa) Rats; Potential Regulation Thereof by Corticotropin‐Releasing Factor

1993 • 60 citations

Metabolic response to a high-fat diet in neonatal and adult rat muscle

1992 • 60 citations

Neuroendocrine Profiles in Galanin-Overexpressing and Knockout Mice

2003 • 59 citations

Modulation of hypothalamic hypocretin/orexin mRNA expression by glucocorticoids

2002 • 58 citations

Galanin-Like Peptide (GALP) Is a Target for Regulation by Leptin in the Hypothalamus of the Rat

2000 • 57 citations

Biochemical, Biophysical, and Pharmacological Characterization of Bacterially Expressed Human Agouti-Related Protein

1998 • 57 citations

Urocortin in the hypothalamic PVN increases leptin and affects uncoupling proteins-1 and -3 in rats

2002 • 57 citations

Interplay Between Galanin and Leptin in the Hypothalamic Control of Feeding via Corticotropin-Releasing Hormone and Neuropeptide Y

2001 • 57 citations

Hypothalamic orexin-A-immunpositive neurons express Fos in response to central glucopenia

2001 • 57 citations

Melanin-Concentrating Hormone Receptor Is a Target of Leptin Action in the Mouse Brain

2001 • 56 citations

Hypothalamic paraventricular nucleus injections of urocortin alter food intake and respiratory quotient

2001 • 56 citations

Role of neuropeptide Y in diet-, chemical- and genetic-induced obesity of mice

1998 • 56 citations

GH-Releasing Peptide-2 Increases Fat Mass in Mice Lacking NPY: Indication for a Crucial Mediating Role of Hypothalamic Agouti-Related Protein

2002 • 56 citations

Increased neuropeptide Y content in the arcuato-paraventricular hypothalamic neuronal system in both insulin-dependent and non-insulin-dependent diabetic rats

1991 • 56 citations

Differential Patterns of Fos Induction in the Hypothalamus of the Rat Following Central Injections of Galanin-Like Peptide and Galanin

2003 • 55 citations

Leptin secretion and hypothalamic neuropeptide and receptor gene expression in sheep

2002 • 55 citations

Cocaine and Amphetamine‐Regulated Transcript mRNA Regulation in the Hypothalamus in Lean and Obese Rodents

2002 • 55 citations

Cocaine- and amphetamine-regulated transcript in the arcuate nucleus stimulates lipid metabolism to control body fat accrual on a high-fat diet

2003 • 54 citations

Comparison of Osborne‐Mendel and S5B/PL Strains of Rat: Central Effects of Galanin, NPY, β‐Casomorphin and CRH on Intake of High‐Fat and Low‐Fat Diets

1996 • 54 citations

Altered Expression of Agouti-Related Protein and Its Colocalization with Neuropeptide Y in the Arcuate Nucleus of the Hypothalamus during Lactation

1999 • 53 citations

Hormonal regulation of appetite and food intake

1998 • 53 citations

Galanin overexpressing transgenic mice

2002 • 53 citations

CNS sensing and regulation of peripheral glucose levels

2002 • 53 citations

Differential proopiomelanocortin gene expression in the medial basal hypothalamus of rats during pregnancy and lactation

1997 • 53 citations

Galanin-Like Peptide Stimulates the Release of Gonadotropin-Releasing Hormonein Vitroand May Mediate the Effects of Leptin on the Hypothalamo-Pituitary-Gonadal Axis

2003 • 50 citations

Rapid changes in hypothalamic neuropeptide Y produced by carbohydrate-rich meals that enhance corticosterone and glucose levels1This manuscript is dedicated to my eminent colleague and dear friend, Dr. Stelios Nicolaidis, who has made so many outstanding contributions and been an enormous inspiration to scientists in the fields of neuroscience and ingestive behavior.1

1999 • 50 citations

Intracerebroventricular Galanin-Like Peptide Induces Different Brain Activation Compared with Galanin

2003 • 50 citations

Ghrelin and Leptin Pulse Discharge in Fed and Fasted Rats

2002 • 50 citations

Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet

2002 • 50 citations

Evidence of an Orexigenic Role for Cocaine- and Amphetamine-Regulated Transcript after Administration into Discrete Hypothalamic Nuclei

2001 • 50 citations

Feeding inhibition by urocortin in the rat hypothalamic paraventricular nucleus

2001 • 50 citations

Distribution of Galanin-Like Peptide in the Rat Brain

2001 • 49 citations

Metabolic effects of galanin injections into the paraventricular nucleus of the hypothalamus

1992 • 49 citations

Rat melanin-concentrating hormone messenger ribonucleic acid expression: marked changes during development and after stress and glucocorticoid stimuli

1992 • 49 citations

Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways

2002 • 49 citations

Galanin-like peptide is co-localized with α-melanocyte stimulating hormone but not with neuropeptide Y in the rat brain

2002 • 48 citations

Blockade of natural and neuropeptide Y-induced carbohydrate feeding by a receptor antagonist PYX-2

1992 • 48 citations

Eating Elicited by Orexin-A, But Not Melanin-Concentrating Hormone, Is Opioid Mediated

2002 • 47 citations

Effect of Progesterone on Galanin mRNA Levels in the Hypothalamus and the Pituitary: Correlation with the Gonadotropin Surge

1993 • 47 citations

β-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R?

2003 • 47 citations

Regulation of feeding behavior, gastric emptying, and sympathetic nerve activity to interscapular brown adipose tissue by galanin and enterostatin: the involvement of vagal-central nervous system interactions

2002 • 47 citations

Orexins and the treatment of obesity

2002 • 47 citations

Effects of a High‐Fat Diet and Strain on Hypothalamic Gene Expression in Rats

2002 • 46 citations

Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats

2002 • 46 citations

d-Fenfluramine induces serotonin-mediated Fos expression in corticotropin-releasing factor and oxytocin neurons of the hypothalamus, and serotonin-independent Fos expression in enkephalin and neurotensin neurons of the amygdala

1999 • 46 citations

Functional characterizations of cocaine- and amphetamine-regulated transcript mRNA expression in rat hypothalamus

2002 • 45 citations

Regulation of corticotropin-releasing factor secretion in vitro by glucose

1988 • 45 citations

Co-existence of leptin- and orexin-receptors in feeding-regulating neurons in the hypothalamic arcuate nucleus—a triple labeling study

2003 • 45 citations

Differential Functions of Galanin Cell Groups in the Regulation of Eating and Body Weight ^a

1998 • 45 citations

Morphological Evidence for a Galanin‐Opiate Interaction in the Rat Mediobasal Hypothalamus

1995 • 45 citations

The Feeding Response to Melanin-Concentrating Hormone Is Attenuated by Antagonism of the NPY Y1-Receptor in the Rat

2002 • 45 citations

Absence of Cocaine- and Amphetamine-Regulated Transcript Results in Obesity in Mice Fed a High Caloric Diet

2001 • 44 citations

Centrally administered galanin inhibits osmotically stimulated arginine vasopressin release in conscious rats

1991 • 44 citations

Food Deprivation Decreases Blood Galanin-Like Peptide and Its Rapid Entry into the Brain

2001 • 43 citations

Diet-induced changes in hypothalamic pro-opio-melanocortin mRNA in the rat hypothalamus

2002 • 43 citations

Central Administration of Cocaine-Amphetamine-Regulated Transcript Activates Hypothalamic Neuroendocrine Neurons in the Rat

2000 • 43 citations

Distribution of galanin-immunoreactive cells within sexually dimorphic components of the medial preoptic area of the male and female rat

1993 • 43 citations

Regulation of Proopiomelanocortin Gene Expression in Rat Brain and Pituitary as Studied by In Situ Hybridization

1993 • 43 citations

Dietary preferences of Brattleboro rats correlated with an overexpression of galanin in the hypothalamus

1999 • 42 citations

Regulation of galanin gene expression in the hypothalamic paraventricular nucleus of the obese Zucker rat by manipulation of dietary macronutrients

1996 • 42 citations

Role of CRH in the effects of 5-HT-receptor agonists on food intake and metabolic rate

1996 • 42 citations

Age-related changes in the diurnal rhythm of CRH gene expression in the paraventricular nuclei

1996 • 41 citations

Diurnal Rhythm in Proopiomelanocortin mRNA in the Arcuate Nucleus of the Male Rat

1994 • 41 citations

Insulin treatment stimulates the rat melanin-concentrating hormone-producing neurons

1994 • 40 citations

Effects of Recombinant Agouti-Signaling Protein on Melanocortin Action

1997 • 39 citations

Fourth ventricular CART reduces food and water intake and produces a conditioned taste aversion in rats.

2002 • 39 citations

CRF-Deficient Mice Respond Like Wild-Type Mice to Hypophagic Stimuli

1999 • 38 citations

Expression of GalR1 and GalR2 Galanin Receptor Messenger Ribonucleic Acid in Proopiomelanocortin Neurons of the Rat Arcuate Nucleus: Effect of Testosterone*

2000 • 38 citations

Increased Colocalization of Corticotropin-Releasing Factor and Arginine Vasopressin in Paraventricular Neurones of the Hypothalamus in Lactating Rats: Evidence from Immunotargeted Lesions and Immunohistochemistry

2001 • 38 citations

Feeding Induced by Pharmacological Blockade of Fatty Acid Metabolism Is Selectively Attenuated by Hindbrain Injections of the Galanin Receptor Antagonist, M40

1996 • 38 citations

Insulin-induced hypoglycaemia increases colocalization of corticotrophin-releasing factor and arginine vasopressin mRNAs in the rat hypothalamic paraventricular nucleus

1994 • 36 citations

Modulation of Urocortin-Induced Hypophagia and Weight Loss by Corticotropin-Releasing Factor Receptor 1 Deficiency in Mice

2000 • 35 citations

Galanin and the galanin antagonist M40 do not change fat intake in a fat-chow choice paradigm in rats

1995 • 35 citations

Disruption of feeding behavior in CRH receptor I-deficient mice is dependent on glucocorticoids

2000 • 34 citations

Melanin-Concentrating Hormone (MCH) Suppresses Thyroid Stimulating Hormone (TSH) release, in Vivo and in Vitro, via the Hypothalamus and the Pituitary

2001 • 34 citations

Etiology and pathophysiology

1985 • 34 citations

Distribution and Regulation of Galanin-Like Peptide (GALP) in the Hypothalamus of the Mouse

2001 • 34 citations

The Peripheral CRH/Urocortin System

2000 • 33 citations

Alteration of the expression of the hypocretin (orexin) gene by 2-deoxyglucose in the rat lateral hypothalamic area

2000 • 33 citations

The effect of dexamethasone on neuropeptide y concentrations in specific hypothalamic regions

1992 • 32 citations

Hypothalamic galanin-like immunoreactivity and its gene expression in relation to circulating corticosterone

1994 • 32 citations

Macronutrients and Brain Peptides

1999 • 32 citations

Hypothalamic Neuropeptide Y and Galanin in Overweight Rats Fed a Cafeteria Diet

1998 • 32 citations

Novel peptide–peptide cooperation may transform feeding behavior

2002 • 32 citations

The effect of insulin-induced hypoglycemia on gene expression in the hypothalamic-pituitary-adrenal axis of the rat.

1992 • 31 citations

Behavioral Neuroscience and Obesity

2003 • 31 citations

Immediate and Prolonged Patterns of Agouti-Related Peptide-(83-132)-Induced c-Fos Activation in Hypothalamic and Extrahypothalamic Sites

2001 • 31 citations

Corticotrophin-releasing hormone, proenkephalin A and oxytocin mRNA's in the paraventricular nucleus during pregnancy and parturition in the rat.

1994 • 30 citations

Urocortin, Corticotropin Releasing Factor-2 Receptors and Energy Balance

2001 • 30 citations

Modulation of hypothalamic galanin gene expression by estrogen in peripubertal rats

1992 • 30 citations

Interaction of Cold and Starvation in the Regulation of Plasma Corticosterone Levels in the Male Rat

1984 • 29 citations

Adrenalectomy prevents the obesity syndrome produced by chronic central neuropeptide Y infusion in normal rats

1997 • 29 citations

Circadian rhythm of corticotropin releasing factor-like immunoreactivity in rat hypothalamus

1984 • 28 citations

Hypothalamic Galanin Gene Expression and Peptide Levels in Relation to Circulating Insulin: Possible Role in Energy Balance

1997 • 28 citations

Agouti-related protein is a mediator of diabetic hyperphagia

2001 • 27 citations

Specific hypothalamic neuropeptide Y variation with diet parameters in rats with food choice

1992 • 27 citations

Enterostatin suppresses food intake in rats after near-celiac and intracarotid arterial injection

2000 • 26 citations

Melanin-concentrating hormone neuron system: the wide web that controls the feeding

2002 • 25 citations

Cocaine-Amphetamine-Regulated Transcript (CART) Acts in the Central Nervous System to Inhibit Gastric Acid Secretion via Brain Corticotropin-Releasing Factor System

2000 • 23 citations

The stimulation of lipogenesis in white adipose tissue from fed rats by corticosterone

1985 • 23 citations

Direct Inhibitory Action of Galanin on Hypothalamic Arcuate Nucleus Neurones Expressing Galanin Receptor Gal-R1 mRNA

2003 • 23 citations

Orexins (hypocretins): novel hypothalamic peptides with divergent functions

2000 • 22 citations

Hormonal regulation of energy partitioning

2000 • 22 citations

Adrenalectomy alters discrete galanin mRNA levels in the hypothalamus and mesencephalon of the rat

1994 • 20 citations

Rat hypothalamic proopiomelanocortin messenger RNA is unaffected by adrenalectomy

1992 • 20 citations

Galanin modulates the activity of proopiomelanocortin neurons in the isolated mediobasal hypothalamus of the male rat

2002 • 19 citations

Effect of inhibition of glucose and fat metabolism on galanin-R1 receptor mRNA levels in the rat hypothalamic paraventricular and supraoptic nuclei

1998 • 19 citations

The social life of NK cells.

2001 • 18 citations

Melanin-concentrating hormone expression in slice cultures of rat hypothalamus is not affected by 2-deoxyglucose

1999 • 16 citations

The Feeding Response to Melanin-Concentrating Hormone Is Attenuated by Antagonism of the NPY Y1-Receptor in the Rat

2002 • 16 citations

Endocrine response to acute cold exposure by lactating and non-lactating norway rats

1986 • 15 citations

On the interations of galanin within the hypothalamic-pituitary axis of the rat

1991 • 15 citations

Glucocorticosteroids up-regulate the expression of cholecystokinin mRNA in the rat paraventricular nucleus

2000 • 14 citations

Disruption of neural signaling within the hypothalamic ventromedial nucleus upregulates galanin gene expression in association with hyperphagia: an in situ hybridization analysis

1999 • 13 citations

Expression of GalR1 and GalR2 Galanin Receptor Messenger Ribonucleic Acid in Proopiomelanocortin Neurons of the Rat Arcuate Nucleus: Effect of Testosterone

2000 • 12 citations

The effect of insulin-induced hypoglycemia on gene expression in the hypothalamic-pituitary-adrenal axis of the rat

1992 • 11 citations

Exploring the expression of the melanin-concentrating hormone messenger RNA in the rat lateral hypothalamus after goldthioglucose injection

1997 • 11 citations

Increased ACTH response to corticotropin-releasing factor in cold-adapted rats in vivo

1989 • 11 citations

Neuropeptide Y Y1 Receptor-Deficient Mice: Generation and Characterization

2003 • 6 citations

Effects of blockers of carbohydrate and lipid metabolism on expression of mRNA of some hypothalamic neuropeptides

2000 • 4 citations

Molecular Genetics of Rodent and Human Single Gene Mutations Affecting Body Composition

2003 • 3 citations