Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide

1982 • 2,244 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS

1984 • 1,274 citations

Neuropeptide Y Distribution in the Rat Brain

1983 • 1,093 citations

The anatomy of neuropeptide-y-containing neurons in rat brain

1985 • 1,086 citations

A receptor subtype involved in neuropeptide-Y-induced food intake

1996 • 892 citations

Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior.

1985 • 731 citations

Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides

1980 • 645 citations

Pancreatic polypeptide family (APP, BPP, NPY and PYY) in relation to sympathetic vasoconstriction resistant to α‐adrenoceptor blockade

1982 • 533 citations

Y-receptor subtypes—how many more?

1997 • 526 citations

Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus

1988 • 510 citations

Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity.

1993 • 466 citations

Role of the Y5 neuropeptide Y receptor in feeding and obesity

1998 • 419 citations

Neuropeptide Y Stimulates Feeding but Inhibits Sexual Behavior in Rats*

1985 • 397 citations

Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor

1998 • 391 citations

Mandatory Neuropeptide-Steroid Signaling for the Preovulatory Luteinizing Hormone-Releasing Hormone Discharge*

1993 • 390 citations

The Central Melanocortin System and Energy Homeostasis

1999 • 349 citations

Cloning and Expression of a Novel Neuropeptide Y Receptor

1996 • 280 citations

Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor

1999 • 276 citations

Norepinephrine-like effects of neuropeptide Y on LH release in the rat

1984 • 270 citations

Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor.

1998 • 230 citations

Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats.

1993 • 202 citations

Hormonal Changes in Puberty III: Correlation of Plasma Dehydroepiandrosterone,Testosterone, FSH, and LH with Stages of Puberty and Bone Age in Normal Boys and Girls and in Patients with Addison's Disease or Hypogonadism or with Premature or Late Adrenarche

1975 • 200 citations

Increased Hypothalamic Content of Preproneuropeptide-Y Messenger Ribonucleic Acid in Streptozotocin-Diabetic Rats*

1990 • 180 citations

Multiple Receptors for the Pancreatic Polypeptide (PP-Fold) Family: Physiological Implications

1998 • 180 citations

Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats.

1996 • 168 citations

Brain neuropeptide Y: An integrator of endocrine, metabolic and behavioral processes

1991 • 148 citations

Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity

1993 • 145 citations

Bimodal Effects of Neuropeptide Y on Hypothalamic Release of Gonadotropin-Releasing Hormone in Conscious Rabbits

1987 • 131 citations

Third-Ventricular Infusion of Neuropeptide Y Suppresses Luteinizing Hormone Secretion in Ovariectomized Rhesus Macaques*

1990 • 125 citations

Characterization of neuropeptide Y binding sites in rat brain membrane preparations using [125I][Leu31,Pro34]peptide YY and [125I]peptide YY3-36 as selective Y1 and Y2 radioligands.

1995 • 122 citations

Neuropeptide Y release from the paraventricular nucleus increases in association with hyperphagia in streptozotocin-induced diabetic rats.

1992 • 115 citations

Evidence That the Inhibition of Luteinizing Hormone Secretion Exerted by Central Administration of Neuropeptide Y (NPY) in the Rat Is Predominantly Mediated by the NPY-Y5 Receptor Subtype1

1999 • 108 citations

Effects of Neuropeptide Y (NPY) on the release of anterior pituitary hormones in the rat

1985 • 105 citations

Physiologically Significant Effect of Neuropeptide Y to Suppress Growth Hormone Release by Stimulating Somatostatin Discharge*

1990 • 103 citations

Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family

1996 • 102 citations

Activation of the NPY Y5 receptor regulates both feeding and energy expenditure

1999 • 101 citations

Neuropeptide-Y Suppresses Pulsatile Secretion of Luteinizing Hormone in Ovariectomized Rats: Possible Site of Action*

1989 • 96 citations

Differential activation of the pituitary-adrenocortical axis after stress in the rat: use of two genetically selected lines (Roman low- and high-avoidance rats) as a model

1989 • 92 citations

Chronic Administration of Neuropeptide Y into the Lateral Ventricle Starting at 30 Days of Life Delays Sexual Maturation in the Female Rat

1995 • 85 citations

Characterization of neuropeptide Y-induced feeding in mice: do Y1-Y6 receptor subtypes mediate feeding?

1999 • 77 citations

Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats

1996 • 68 citations

Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats

1993 • 62 citations

Neuropeptide Y release from the paraventricular nucleus increases in association with hyperphagia in streptozotocin-induced diabetic rats

1992 • 56 citations

Chronic Blockade of the Melanocortin 4 Receptor Subtype Leads to Obesity Independently of Neuropeptide Y Action, with No Adverse Effects on the Gonadotropic and Somatotropic Axes**This work was supported by grants from the Swiss National Research Science Foundation (31–39729-93, 31–55732-98, and 32–04912 3–97) and in part by Ferring Pharmaceuticals Ltd. Research Laboratories.

2000 • 54 citations

Differential Effects of Pancreatic Polypeptide on Luteinizing Hormone Release in Female Rats

1984 • 53 citations

Pharmacological characterization of the cloned neuropeptide Y y6 receptor

2000 • 44 citations

Evidence That the Inhibition of Luteinizing Hormone Secretion Exerted by Central Administration of Neuropeptide Y (NPY) in the Rat Is Predominantly Mediated by the NPY-Y5 Receptor Subtype

1999 • 35 citations

Chronic Blockade of the Melanocortin 4 Receptor Subtype Leads to Obesity Independently of Neuropeptide Y Action, with No Adverse Effects on the Gonadotropic and Somatotropic Axes

2000 • 30 citations