Differential Role of Melanocortin Receptor Subtypes in Cachexia

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1998 • 1,666 citations

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

1996 • 1,020 citations

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

2000 • 878 citations

A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

2000 • 677 citations

Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus

1999 • 603 citations

The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis

2001 • 564 citations

Biology of Cachexia

1997 • 486 citations

Anatomy of an Endogenous Antagonist: Relationship between Agouti-Related Protein and Proopiomelanocortin in Brain

1999 • 411 citations

alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain.

1978 • 352 citations

Distribution of fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration

1996 • 335 citations

Feeding and body-weight regulation by hypothalamic neuropeptides—mediation of the actions of leptin

1999 • 330 citations

Obesity, diabetes, and neoplasia in yellow A ^vy /‐ mice: ectopic expression of the agouti gene

1994 • 306 citations

Anorexia of infection as a mechanism of host defense

1979 • 301 citations

Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.

1995 • 290 citations

Role of the central melanocortin system in cachexia.

2001 • 286 citations

Cytokines, sepsis and immunomodulation

1993 • 219 citations

Reversal of Cancer Anorexia by Blockade of Central Melanocortin Receptors in Rats

2001 • 216 citations

Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity

2002 • 210 citations

Endotoxin-induced appearance of immunoreactive interleukin-1β in ramified microglia in rat brain: A light and electron microscopic study

1995 • 193 citations

Localization of type I interleukin-1 receptor mRNA in the rat brain

1994 • 183 citations

Role of central melanocortins in endotoxin-induced anorexia

1999 • 149 citations

A simple method for carcass analysis

1972 • 143 citations

Anti-interferon-γ antibody treatment, growth of Lewis lung tumours in mice and tumour-associated cachexia

1991 • 142 citations

Signals involved in interleukin 1 synthesis and release by lipopolysaccharide-stimulated monocytes/macrophages

1990 • 101 citations

Antipyretic Role of Endogenous Melanocortins Mediated by Central Melanocortin Receptors during Endotoxin-Induced Fever

1997 • 98 citations

EXPRESSION OF INTERLEUKIN 1α AND β, AND INTERLEUKIN 1 RECEPTOR ANTAGONIST mRNA IN THE RAT CENTRAL NERVOUS SYSTEM AFTER PERIPHERAL ADMINISTRATION OF LIPOPOLYSACCHARIDES

2000 • 92 citations

Chronic Central Melanocortin-4 Receptor Antagonism and Central Neuropeptide-Y Infusion in Rats Produce Increased Adiposity by Divergent Pathways

2002 • 86 citations

Immunomodulators and feeding regulation: A humoral link between the immune and nervous systems

1989 • 86 citations

Anorexic But Not Pyrogenic Actions of Interleukin‐1 are Modulated by Central Melanocortin‐3/4 Receptors in the Rat

2001 • 85 citations

Protein turnover in skeletal muscle of tumour-bearing transgenic mice overexpressing the soluble TNF receptor-1

1998 • 78 citations

Lipopolysaccharide (LPS)- and muramyl dipeptide (MDP)-induced anorexia during refeeding following acute fasting: characterization of brain cytokine and neuropeptide systems mRNAs

1998 • 77 citations

Reversal of Cancer Anorexia by Blockade of Central Melanocortin Receptors in Rats

2001 • 70 citations

Peripheral endotoxin induces hypothalamic immunoreactive interleukin‐1β in the rat

1993 • 64 citations

Systemic α-MSH suppresses LPS fever via central melanocortin receptors independently of its suppression of corticosterone and IL-6 release

1998 • 63 citations

Brain mechanisms in cytokine-induced anorexia

1999 • 60 citations

Interleukin-1 activation of FOS proto-oncogene protein in the rat hypothalamus

1993 • 55 citations

Chronic Application of MTII in a Rat Model of Obesity Results in Sustained Weight Loss

2002 • 52 citations

The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis

2001 • 50 citations

Disproportionate Inhibition of Feeding in <i>A<sup>y</sup></i> Mice by Certain Stressors: A Cautionary Note

2000 • 46 citations

Thwarting the dwindling progression of cachexia

1998 • 44 citations

Endotoxin-elicited fever and anorexia and elfazepam-stimulated feeding in sheep

1981 • 36 citations

Evidence for a different sensitivity to various central effects of interleukin-1 β in mice

1992 • 27 citations

Agonism at melanocortin receptor type 3 on macrophages inhibits neutrophil influx

1999 • 16 citations

Modulation of interleukin‐1 receptos in the neuro‐endocrine‐immune axis

1995 • 13 citations

Antitumor and Other Effects of 24<i>R</i>,25-Dihydroxycholecalciferol in Lewis Lung Carcinoma Causing Abnormal Calcium Metabolism in Tumor-Bearing Mice

1988 • 10 citations