Dose-Dependent Effects of Central Leptin Gene Therapy on Genes That Regulate Body Weight and Appetite in the Hypothalamus

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*

1999 • 1,467 citations

NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS

1984 • 1,274 citations

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

1993 • 1,057 citations

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

1997 • 1,043 citations

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

1997 • 750 citations

Novel Tools for Production and Purification of Recombinant Adenoassociated Virus Vectors

1998 • 691 citations

Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food.

1991 • 678 citations

Coexpression of Leptin Receptor and Preproneuropeptide Y mRNA in Arcuate Nucleus of Mouse Hypothalamus

1996 • 473 citations

CNS origins of the sympathetic nervous system outflow to brown adipose tissue

1999 • 426 citations

The adipoinsular axis: effects of leptin on pancreatic β-cells

2000 • 423 citations

Hypothalamic Agouti-Related Protein Messenger Ribonucleic Acid Is Inhibited by Leptin and Stimulated by Fasting*

1999 • 374 citations

Leptin Gene Expression in the Brain and Pituitary Gland

1999 • 369 citations

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

1996 • 321 citations

Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice.

1997 • 301 citations

A Leptin Dose-Response Study in Obese (ob/ob) and Lean (+/?) Mice

1998 • 296 citations

Effects of Leptin on Insulin Sensitivity in Normal Rats*

1997 • 271 citations

Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats.

2000 • 214 citations

Leptin induction of UCP1 gene expression is dependent on sympathetic innervation

1998 • 206 citations

Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice

1999 • 196 citations

[48] Production and purification of recombinant adeno-associated virus

2000 • 164 citations

Adeno-associated virus vectors

1992 • 161 citations

Correction of obesity and diabetes in genetically obese mice by leptin gene therapy

1996 • 160 citations

Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis.

1992 • 159 citations

Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin

1997 • 124 citations

Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study

2001 • 100 citations

Dynamic regulation of leptin entry into brain by the blood–brain barrier

2000 • 95 citations

Cross-Sectional and Longitudinal Analysis of Age-Associated Changes in Body Composition of Male Brown Norway Rats: Association of Serum Leptin Levels With Peripheral Adiposity

1999 • 95 citations

Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis [published erratum appears in Endocrinology 1996 Feb;137(2):532]

1992 • 91 citations

Physiology of transgenic mice with brown fat ablation: obesity is due to lowered body temperature

1998 • 90 citations

Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia

1999 • 86 citations

Leptin Affects Pancreatic Endocrine Functions through the Sympathetic Nervous System¹

1998 • 79 citations

Differential Expression of ob mRNA in Rat Adipose Tissues in Response to Insulin

1996 • 79 citations

Leptin physiology: a second look

2000 • 74 citations

The Effects of a High Fat Diet on Leptin mRNA, Serum Leptin and the Response to Leptin Are Not Altered in a Rat Strain Susceptible to High Fat Diet-Induced Obesity

1998 • 69 citations

Neural control of brown adipose tissue thermogenesis, hypertrophy, and atrophy

1991 • 68 citations

NPY Y1 receptor like immunoreactivity exists in a subpopulation of β-endorphin immunoreactive nerve cells in the arcuate nucleus: a double immunolabelling analysis in the rat

1997 • 65 citations

Chronic leptin administration promotes lipid utilization until fat mass is greatly reduced and preserves lean mass of normal female rats

2000 • 62 citations

Regulation of proopiomelanocortin gene expression by neuropeptide Y in the rat arcuate nucleus

1995 • 62 citations

Hyperleptinemia Depletes Fat from Denervated Fat Tissue

1999 • 53 citations

Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice

2000 • 53 citations

Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors.

1998 • 47 citations

Leptin gene therapy and daily protein administration: a comparative study in the ob/ob mouse

1998 • 45 citations

Regulation of leptin secretion: effects of aging on daily patterns of serum leptin and food consumption

2000 • 42 citations

Direct delivery of leptin to the hypothalamus using recombinant adeno-associated virus vectors results in increased therapeutic efficacy

2001 • 25 citations

Melanocortin signaling is decreased during neurotoxin-induced transient hyperphagia and increased body-weight gain

2000 • 16 citations