Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

Central nervous system control of food intake

2000 • 6,305 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Ghrelin induces adiposity in rodents

2000 • 3,915 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

A role for ghrelin in the central regulation of feeding

2001 • 3,415 citations

Ghrelin Enhances Appetite and Increases Food Intake in Humans

2001 • 2,330 citations

Circulating Ghrelin Levels Are Decreased in Human Obesity

2001 • 1,999 citations

Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans¹

2000 • 1,794 citations

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

2003 • 1,617 citations

The role of depot fat in the hypothalamic control of food intake in the rat

1953 • 1,400 citations

Stomach Is a Major Source of Circulating Ghrelin, and Feeding State Determines Plasma Ghrelin-Like Immunoreactivity Levels in Humans

2001 • 1,231 citations

The stomach is a source of leptin

1998 • 1,215 citations

Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin

2001 • 1,181 citations

Ghrelin Causes Hyperphagia and Obesity in Rats

2001 • 1,121 citations

The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats

2002 • 1,055 citations

Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

2001 • 862 citations

American Physiological Society

1922 • 803 citations

Chronic Central Infusion of Ghrelin Increases Hypothalamic Neuropeptide Y and Agouti-Related Protein mRNA Levels and Body Weight in Rats

2001 • 617 citations

Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats

1997 • 522 citations

Food Fails to Suppress Ghrelin Levels in Obese Humans

2002 • 517 citations

Guiding principles for research involving animals and human beings

2002 • 477 citations

Acute Central Ghrelin and GH Secretagogues Induce Feeding and Activate Brain Appetite Centers

2002 • 420 citations

Central Effect of Ghrelin, an Endogenous Growth Hormone Secretagogue, on Hypothalamic Peptide Gene Expression

2000 • 362 citations

Overfeeding Rapidly Induces Leptin and Insulin Resistance

2001 • 353 citations

Leptin selectively decreases visceral adiposity and enhances insulin action.

1997 • 349 citations

Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity

2002 • 290 citations

Induction of c-fos Messenger Ribonucleic Acid in Neuropeptide Y and Growth Hormone (GH)-Releasing Factor Neurons in the Rat Arcuate Nucleus Following Systemic Injection of the GH Secretagogue, GH-Releasing Peptide-6*

1997 • 285 citations

The Insulin Resistance—Dyslipidemic Syndrome of Visceral Obesity: Effect on Patients' Risk

1998 • 269 citations

Reduced central leptin sensitivity in rats with diet-induced obesity

2002 • 266 citations

Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus

2002 • 257 citations

Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats

2002 • 245 citations

Fasting Plasma Ghrelin Levels Are Negatively Correlated With Insulin Resistance and PAI-1, but Not With Leptin, in Obese Children and Adolescents

2002 • 225 citations

Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity

2002 • 215 citations

Delayed Short-Term Secretory Regulation of Ghrelin in Obese Animals: Evidenced by a Specific RIA for the Active Form of Ghrelin

2002 • 215 citations

Fat Intake Affects Adiposity, Comorbidity Factors, and Energy Metabolism of Sprague‐Dawley Rats

2002 • 214 citations

Metabolic differences between obesity-prone and obesity-resistant rats

1990 • 185 citations

Plasma Ghrelin Concentration and Energy Balance: Overfeeding and Negative Energy Balance Studies in Twins

2001 • 171 citations

Initiation and perpetuation of obesity and obesity resistance in rats

1989 • 148 citations

Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet-induced obese rats

1997 • 133 citations

Ghrelin, Macronutrient Intake and Dietary Preferences in Long–Evans Rats

2002 • 131 citations

Low Plasma Leptin in Response to Dietary Fat in Diabetes- and Obesity-Prone Mice

1997 • 125 citations

Relationship between sympathetic activity and diet-induced obesity in two rat strains

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Ontogeny of diet-induced obesity in selectively bred Sprague-Dawley rats

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Resistance to diet-induced obesity: food intake, pancreatic sympathetic tone, and insulin

1987 • 98 citations

Metabolic features of diet-induced obesity without hyperphagia in young rats

1986 • 77 citations

The Effects of a High Fat Diet on Leptin mRNA, Serum Leptin and the Response to Leptin Are Not Altered in a Rat Strain Susceptible to High Fat Diet-Induced Obesity

1998 • 69 citations

Early Leptin Response to a Palatable Diet Predicts Dietary Obesity in Rats: Key Role of Melanocortin‐4 Receptors in the Ventromedial Hypothalamic Nucleus

2000 • 61 citations

Dissociation of charge movement from calcium release and calcium current in skeletal myotubes by gabapentin

2002 • 54 citations

Phenotypic Consequences of a Nonsense Mutation in the Leptin Receptor Gene (fak) in Obese Spontaneously Hypertensive Koletsky Rats (SHROB)

1998 • 54 citations

Fasting serum insulin in relation to components of the metabolic syndrome in European healthy men: The European fat distribution study

1995 • 48 citations

Role of autonomic nervous system in postprandial thermogenesis in dogs

1987 • 38 citations

Actions of Leptin on Growth Hormone Secretagogue-Responsive Neurones in the Rat Hypothalamic Arcuate Nucleus Recorded In Vitro

2001 • 33 citations