Fibroblast growth factors, their receptors and signaling.

Thalidomide is an inhibitor of angiogenesis.

1994 • 2,460 citations

Protein modules and signalling networks

1995 • 2,447 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Receptor Specificity of the Fibroblast Growth Factor Family

1996 • 1,871 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

Intracellular protein topogenesis

1980 • 1,378 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

Structural and Functional Diversity in the FGf Receptor Multigene Family

1992 • 1,262 citations

Fgf10 is essential for limb and lung formation

1999 • 1,204 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

The proximo‐distal sequence of origin of the parts of the chick wing and the role of the ectoderm

1948 • 1,101 citations

THALIDOMIDE AND CONGENITAL ABNORMALITIES

1961 • 1,089 citations

Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes

1991 • 1,088 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

1988 • 892 citations

FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate

1998 • 868 citations

A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway

1997 • 861 citations

Heparin protects basic and acidic FGF from inactivation

1986 • 856 citations

Purification and characterization of a newly identified growth factor specific for epithelial cells.

1989 • 842 citations

Glycosaminoglycans and Their Binding to Biological Macromolecules

1978 • 835 citations

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

1988 • 810 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Heparin Structure and Interactions with Basic Fibroblast Growth Factor

1996 • 789 citations

Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis

1999 • 788 citations

Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth

1974 • 786 citations

A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence.

1990 • 770 citations

Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

1992 • 760 citations

Requirement of FGF-4 for Postimplantation Mouse Development

1995 • 743 citations

Midbrain development induced by FGF8 in the chick embryo

1996 • 734 citations

Positional Information in Chick Limb Morphogenesis

1973 • 718 citations

Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.

1985 • 710 citations

Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization

1986 • 679 citations

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

1994 • 665 citations

FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb

1993 • 660 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

The roles of FGFs in the early development of vertebrate limbs

1998 • 659 citations

High and low affinity binding sites for basic fibroblast growth factor on cultured cells: Absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells

1987 • 653 citations

Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo

1999 • 644 citations

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

1990 • 635 citations

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

1992 • 634 citations

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules

1989 • 597 citations

Structural Basis for FGF Receptor Dimerization and Activation

1999 • 597 citations

Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2

1998 • 593 citations

A dual receptor system is required for basic fibroblast growth factor activity

1991 • 589 citations

Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development

1996 • 588 citations

Fibroblast growth factors induce additional limb development from the flank of chick embryos

1995 • 578 citations

Developmental Localization of the Splicing Alternatives of Fibroblast Growth Factor Receptor-2 (FGFR2)

1993 • 551 citations

Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.

1990 • 545 citations

Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis

1994 • 541 citations

Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.

1989 • 527 citations

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family

1987 • 525 citations

An Essential Heparin-Binding Domain in the Fibroblast Growth Factor Receptor Kinase

1993 • 520 citations

Salvage of Infarcted Myocardium by Angiogenic Action of Basic Fibroblast Growth Factor

1992 • 519 citations

Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis

1999 • 516 citations

Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha.

1992 • 500 citations

Regulation of signal transduction and signal diversity by receptor oligomerization

1994 • 485 citations

A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas

1988 • 481 citations

FGF-2: Apical Ectodermal Ridge Growth Signal for Chick Limb Development

1994 • 470 citations

Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum‐Golgi complex

1992 • 461 citations

Effects of Thalidomide and Related Metabolites in a Mouse Corneal Model of Neovascularization

1997 • 447 citations

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.

1991 • 443 citations

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1992 • 438 citations

Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice

1998 • 437 citations

Identification and characterization of a novel cytoskeleton-associated pp60src substrate.

1991 • 435 citations

The phagokinetic tracks of 3T3 cells

1977 • 434 citations

The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

1988 • 425 citations

Growth factors are released by mechanically wounded endothelial cells.

1989 • 420 citations

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

1992 • 414 citations

Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy.

1993 • 408 citations

The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.

1991 • 406 citations

Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.

1992 • 404 citations

Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis

1999 • 397 citations

Heparin Binds Endothelial Cell Growth Factor, the Principal Endothelial Cell Mitogen in Bovine Brain

1984 • 391 citations

Molecular Cloning of a Novel Cytokine cDNA Encoding the Ninth Member of the Fibroblast Growth Factor Family, which has a Unique Secretion Property

1993 • 390 citations

Pituitary Extracts and Steroid Hormones in the Control of 3T3 Cell Growth

1973 • 387 citations

Three-Dimensional Structures of Acidic and Basic Fibroblast Growth Factors

1991 • 386 citations

Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

1996 • 385 citations

Identification of Six Novel Autophosphorylation Sites on Fibroblast Growth Factor Receptor 1 and Elucidation of Their Importance in Receptor Activation and Signal Transduction

1996 • 385 citations

The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells.

1987 • 378 citations

Fibroblast growth factor 2 control of vascular tone

1998 • 376 citations

Recovery of Mitogenic Activity of a Growth Factor Mutant with a Nuclear Translocation Sequence

1990 • 373 citations

Tumorigenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region int-2

1984 • 356 citations

FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors

2000 • 355 citations

The identification and partial characterization of the fibroblast growth factor receptor of baby hamster kidney cells.

1985 • 352 citations

Diverse forms of a receptor for acidic and basic fibroblast growth factors.

1990 • 352 citations

Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor.

1991 • 346 citations

Basic and acidic fibroblast growth factors interact with the same cell surface receptors.

1986 • 340 citations

Brain-Derived Acidic Fibroblast Growth Factor: Complete Amino Acid Sequence and Homologies

1985 • 335 citations

Nuclear and cytoplasmic localization of different basic fibroblast growth factor species

1990 • 332 citations

THALIDOMIDE AND CONGENITAL ABNORMALITIES

1962 • 326 citations

Keratinocyte growth factor

1995 • 321 citations

Receptor- and heparin-binding domains of basic fibroblast growth factor.

1988 • 318 citations

Compensation by Fibroblast Growth Factor 1 (FGF1) Does Not Account for the Mild Phenotypic Defects Observed in FGF2 Null Mice

2000 • 316 citations

Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary cell culture.

1984 • 315 citations

Characterization of Recombinant Human Fibroblast Growth Factor (FGF)-10 Reveals Functional Similarities with Keratinocyte Growth Factor (FGF-7)

1998 • 307 citations

Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice.

1990 • 307 citations

Interaction of heparin with human basic fibroblast growth factor: Protection of the angiogenic protein from proteolytic degradation by a glycosaminoglycan

1989 • 304 citations

Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1

1994 • 301 citations

Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.

1989 • 294 citations

cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity.

1987 • 293 citations

Subcellular fate of the lnt-2 oncoprotein is determined by choice of initiation codon

1990 • 293 citations

Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin.

1992 • 287 citations

Structure and Expression of the Rat mRNA Encoding a Novel Member of the Fibroblast Growth Factor Family

1996 • 285 citations

Gene expression of fibroblast growth factors in human gliomas and meningiomas: demonstration of cellular source of basic fibroblast growth factor mRNA and peptide in tumor tissues.

1990 • 279 citations

Alterations in expression of basic fibroblast growth factor (FGF) 2 and its receptor FGFR-1 in human prostate cancer.

1999 • 277 citations

Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa.

1986 • 277 citations

Purification and characterization of acidic fibroblast growth factor from bovine brain.

1984 • 267 citations

Fibroblast Growth Factor in the Extracellular Matrix of Dystrophic (mdx) Mouse Muscle

1989 • 263 citations

Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo.

1988 • 261 citations

Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta.

1991 • 248 citations

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.

1987 • 247 citations

Heat shock induces the release of fibroblast growth factor 1 from NIH 3T3 cells.

1992 • 247 citations

A secreted FGF-binding protein can serve as the angiogenic switch in human cancer

1997 • 244 citations

Multivalent Ligand-Receptor Binding Interactions in the Fibroblast Growth Factor System Produce a Cooperative Growth Factor and Heparin Mechanism for Receptor Dimerization

1994 • 239 citations

Structural interactions of fibroblast growth factor receptor with its ligands

2000 • 231 citations

A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1

1997 • 228 citations

Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain

1999 • 226 citations

Dual mode of signal transduction by externally added acidic fibroblast growth factor

1994 • 223 citations

Basic fibroblast growth factor released by single, isolated cells stimulates their migration in an autocrine manner.

1991 • 211 citations

Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).

1989 • 203 citations

Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

1990 • 195 citations

Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries.

1988 • 193 citations

Fibroblast Growth Factor-10

1999 • 189 citations

Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas

1999 • 189 citations

mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation

1991 • 189 citations

Ligand-induced transphosphorylation between different FGF receptors.

1991 • 189 citations

Keratinocyte growth factor functions in epithelial induction during seminal vesicle development.

1994 • 187 citations

Vascular endothelial growth factor and basic fibroblast growth factor present in Kaposi's sarcoma (KS) are induced by inflammatory cytokines and synergize to promote vascular permeability and KS lesion development.

1998 • 186 citations

Detection of high levels of heparin binding growth factor-1 (acidic fibroblast growth factor) in inflammatory arthritic joints.

1990 • 185 citations

Heparin potentiates the action of acidic fibroblast growth factor by prolonging its biological half‐life

1989 • 181 citations

The int-2 proto-oncogene is responsible for induction of the inner ear

1991 • 181 citations

Acidic fibroblast growth factor (FGF) from bovine brain: amino-terminal sequence and comparison with basic FGF.

1985 • 178 citations

Basic fibroblast growth factor (bFGF) upregulates the expression of bcl-2 in B cell chronic lymphocytic leukemia cell lines resulting in delaying apoptosis

1997 • 177 citations

Specific binding of basic fibroblast growth factor to basement membrane‐like structures and to purified heparan sulfate proteoglycan of the EHS tumor

1988 • 172 citations

Profound Ligand-Independent Kinase Activation of Fibroblast Growth Factor Receptor 3 by the Activation Loop Mutation Responsible for a Lethal Skeletal Dysplasia, Thanatophoric Dysplasia Type II

1996 • 172 citations

Association of fibroblast growth factor receptor-1 with c-Src correlates with association between c-Src and cortactin.

1994 • 168 citations

Novel Recognition Motif on Fibroblast Growth Factor Receptor Mediates Direct Association and Activation of SNT Adapter Proteins

1998 • 167 citations

Correlation of basic fibroblast growth factor expression levels with the degree of malignancy and vascularity in human gliomas

1992 • 166 citations

Complete primary structure of prostatropin, a prostate epithelial cell growth factor

1986 • 163 citations

Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction.

1992 • 162 citations

Heparin Is Required for Cell-Free Binding of Basic Fibroblast Growth Factor to a Soluble Receptor and for Mitogenesis in Whole Cells

1992 • 160 citations

Protein Modules and Signaling Networks

2000 • 159 citations

Ligand-independent Activation of Fibroblast Growth Factor Receptors by Point Mutations in the Extracellular, Transmembrane, and Kinase Domains

1996 • 155 citations

Mesoderm-inducing properties of INT-2 and kFGF: two oncogene-encoded growth factors related to FGF

1989 • 154 citations

Structure and Expression of a Novel Member, FGF-16, of the Fibroblast Growth Factor Family

1998 • 152 citations

FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro

1993 • 151 citations

Structure and Expression of the mRNA Encoding a Novel Fibroblast Growth Factor, FGF-18

1998 • 150 citations

Glycosylation allows cell-surface transport of an anchored secretory protein

1985 • 145 citations

Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin.

1992 • 143 citations

Thalidomide and Congenital Abnormalities

1961 • 142 citations

Fgf-8, activated by proviral insertion, cooperates with the Wnt-1 transgene in murine mammary tumorigenesis

1995 • 142 citations

Basic Fibroblast Growth Factor Increases Expression of the αvβ3 Integrin Complex on Human Microvascular Endothelial Cells

1994 • 140 citations

Identification and concerted function of two receptor binding surfaces on basic fibroblast growth factor required for mitogenesis.

1994 • 139 citations

[9] Isolation and characterization of acidic and basic fibroblast growth factor

1987 • 139 citations

Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.

1991 • 135 citations

Fibroblast Growth Factor Receptors (FGFRs) Localize in Different Cellular Compartments

1995 • 133 citations

Specific fixation of bovine brain and retinal acidic and basic fibroblast growth factors to mouse embryonic eye basement membranes

1987 • 133 citations

Exon Switching and Activation of Stromal and Embryonic Fibroblast Growth Factor (FGF)-FGF Receptor Genes in Prostate Epithelial Cells Accompany Stromal Independence and Malignancy

1993 • 131 citations

FGF Is an Essential Regulator of the Fifth Cell Division in Preimplantation Mouse Embryos

1998 • 126 citations

Isolation of a rearranged human transforming gene following transfection of Kaposi sarcoma DNA.

1987 • 125 citations

Fibroblast growth factor 4 transfection of MCF-7 cells produces cell lines that are tumorigenic and metastatic in ovariectomized or tamoxifen-treated athymic nude mice.

1993 • 125 citations

Tumor growth and angiogenesis induced by a secreted binding protein for fibroblast growth factors.

1994 • 125 citations

The Human Fibroblast Growth Factor Receptor Genes: a Common Structural Arrangement Underlies the Mechanisms for Generating Receptor Forms That Differ in Their Third Immunoglobulin Domain

1991 • 123 citations

Induction of platelet‐derived growth factor A and B chains and over‐expression of their receptors in human pancreatic cancer

1995 • 123 citations

Structure and Expression of Human Fibroblast Growth Factor-10

1997 • 122 citations

Heparin-binding keratinocyte growth factor is a candidate stromal-to- epithelial-cell andromedin

1992 • 121 citations

S100A13 Is Involved in the Regulation of Fibroblast Growth Factor-1 and p40 Synaptotagmin-1 Release in Vitro

1998 • 119 citations

Competition between nuclear localization and secretory signals determines the subcellular fate of a single CUG-initiated form of FGF3.

1994 • 119 citations

Keratinocyte growth factor induces angiogenesis and protects endothelial barrier function

1999 • 119 citations

Multiple forms of basic fibroblast growth factor: amino-terminal cleavages by tumor cell- and brain cell-derived acid proteinases.

1987 • 117 citations

Genomic structure, mapping, activity and expression of fibroblast growth factor 17

1999 • 115 citations

Proposed mechanisms of action in thalidomide embryopathy

1988 • 114 citations

Basic fibroblast growth factor (bFGF) dissociates rapidly from heparan sulfates but slowly from receptors. Implications for mechanisms of bFGF release from pericellular matrix.

1992 • 114 citations

The characterization of the receptor for endothelial cell growth factor by covalent ligand attachment.

1986 • 111 citations

Fibroblast Growth Factor Receptor-1-mediated Endothelial Cell Proliferation Is Dependent on the Src Homology (SH) 2/SH3 Domain-containing Adaptor Protein Crk

1999 • 110 citations

Murine cortactin is phosphorylated in response to fibroblast growth factor-1 on tyrosine residues late in the G1 phase of the BALB/c 3T3 cell cycle.

1993 • 109 citations

The Release of Fibroblast Growth Factor-1 from NIH 3T3 Cells in Response to Temperature Involves the Function of Cysteine Residues

1995 • 107 citations

The Heparin-Binding (Fibroblast) Growth Factor Family Of Proteins

1989 • 106 citations

The murine flg gene encodes a receptor for fibroblast growth factor.

1990 • 106 citations

Tumor Growth Dependent on Kaposi's Sarcoma-Derived Fibroblast Growth Factor Inhibited by Pentosan Polysulfate

1991 • 106 citations

Evidence and characterization of the receptor to eye-derived growth factor I, the retinal form of basic fibroblast growth factor, on bovine epithelial lens cells.

1986 • 105 citations

FGFR2 mutation associated with clinical manifestations consistent with Antley-Bixler syndrome

1998 • 104 citations

Fibroblast growth factor receptor gene expression and immunoreactivity are elevated in human glioblastoma multiforme.

1994 • 104 citations

Basic Fibroblast Growth Factor Is Neither Necessary nor Sufficient for the Development of Retinal Neovascularization

1998 • 103 citations

Divalent Cations and Heparin/Heparan Sulfate Cooperate to Control Assembly and Activity of the Fibroblast Growth Factor Receptor Complex

1996 • 103 citations

Structure and Expression of a Novel Fibroblast Growth Factor, FGF-17, Preferentially Expressed in the Embryonic Brain

1998 • 103 citations

Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras.

1996 • 102 citations

Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actions

1997 • 101 citations

Alternative Initiation of Translation Determines Cytoplasmic or Nuclear Localization of Basic Fibroblast Growth Factor

1991 • 101 citations

Diverse Forms of a Receptor for Acidic and Basic Fibroblast Growth Factors

1990 • 100 citations

Production, biological activity, and structure of recombinant basic fibroblast growth factor and an analog with cysteine replaced by serine.

1988 • 100 citations

The Human FGF-5 Oncogene Encodes a Novel Protein Related to Fibroblast Growth Factors

1988 • 98 citations

Characterization of Chicken Syndecan-3 as a Heparan Sulfate Proteoglycan and Its Expression during Embryogenesis

1995 • 94 citations

FGF-8 isoforms differ in NIH3T3 cell transforming potential.

1995 • 94 citations

Fibroblast growth factor receptor-1 regulation of Src family kinases.

1995 • 91 citations

Thalidomide and a thalidomide analogue inhibit endothelial cell proliferation in vitro.

1999 • 90 citations

Molecular embryology of the lung: then, now, and in the future

1999 • 88 citations

Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.

1994 • 88 citations

Crystal Structure of Basic Fibroblast Growth Factor at 1.6 Å Resolution

1991 • 87 citations

Mutation associated with Crouzon syndrome causes ligand-independent dimerization and activation of FGF receptor-2

1997 • 84 citations

Elucidation of a signaling pathway induced by FGF-2 leading to uPA gene expression in NIH 3T3 fibroblasts.

1995 • 82 citations

The Expression and Localization of Fibroblast Growth Factor-1 (FGF-1) and FGF Receptor-1 (FGFR-1) in Human Breast Cancer

1998 • 78 citations

Comparison of the intracellular signaling responses by three chimeric fibroblast growth factor receptors in PC12 cells

1999 • 78 citations

Phenotype of the fibroblast growth factor receptor 2 Ser351Cys mutation: Pfeiffer syndrome type III

1998 • 77 citations

Fibroblast Growth Factor 3, a Protein with Dual Subcellular Localization, Is Targeted to the Nucleus and Nucleolus by the Concerted Action of Two Nuclear Localization Signals and a Nucleolar Retention Signal

1997 • 77 citations

Thrombin inactivates acidic fibroblast growth factor but not basic fibroblast growth factor

1988 • 77 citations

Synaptotagmin-1 Is Required for Fibroblast Growth Factor-1 Release

1998 • 73 citations

Basic Fibroblast Growth Factor Downregulates Bcl-2 and Promotes Apoptosis in MCF-7 Human Breast Cancer Cells

1998 • 72 citations

The Extravesicular Domain of Synaptotagmin-1 Is Released with the Latent Fibroblast Growth Factor-1 Homodimer in Response to Heat Shock

1998 • 72 citations

Suppression of fibroblast growth factor receptor signaling inhibits pancreatic cancer growth in vitro and in vivo

1998 • 71 citations

Molecular characteristics of fibroblast growth factor–fibroblast growth factor receptor–heparin-like glycosaminoglycan complex

1999 • 71 citations

Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis

1997 • 69 citations

Biosynthesis of human fibroblast growth factor-5.

1991 • 68 citations

Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells.

1989 • 67 citations

Basic fibroblast growth factor is a substrate for protein phosphorylation and is phosphorylated by capillary endothelial cells in culture.

1989 • 65 citations

Effect of basic fibroblast growth factor on angiogenesis in the infarcted porcine heart

1998 • 64 citations

Biological equivalence of natural bovine and recombinant human alpha-endothelial cell growth factors.

1987 • 63 citations

Expression of fibroblast growth factor and FGF-receptor family genes in human myeloma cells, including lines possessing t(4;14)(q16.3;q32. 3) and FGFR3 translocation.

1999 • 61 citations

Culture‐induced increase in acidic and basic fibroblast growth factor activities and their association with the nuclei of vascular endothelial and smooth muscle cells

1991 • 61 citations

Human oncogenes detected by a defined medium culture assay.

1987 • 61 citations

Gene expression of fibroblast growth factor receptors in the tissues of human gliomas and meningiomas

1991 • 60 citations

Reductive methylation of lysine residues in acidic fibroblast growth factor: effect on mitogenic activity and heparin affinity

1988 • 60 citations

Stoichiometry of Heparin Binding to Basic Fibroblast Growth Factor

1994 • 58 citations

Nucleolar Association of Fibroblast Growth Factor 3 via Specific Sequence Motifs Has Inhibitory Effects on Cell Growth

1995 • 57 citations

Thalidomide and Congenital Abnormalities

1962 • 56 citations

Novel Tyrosine Kinase Identified by Phosphotyrosine Antibody Screening of cDNA Libraries

1988 • 55 citations

Fibroblast growth factor-1 (FGF-1) enhances IL-2 production and nuclear translocation of NF-kappaB in FGF receptor-bearing Jurkat T cells.

1999 • 54 citations

A growth-promoting influence from the mesonephros during limb outgrowth

1992 • 53 citations

Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5.

1993 • 52 citations

Intracellular Protein Topogenesis

1981 • 52 citations

In vivo inhibition of angiogenesis and induction of apoptosis by retinoic acid in squamous cell carcinoma.

1997 • 52 citations

Induction of FGF-7 after kidney damage: a possible paracrine mechanism for tubule repair

1996 • 51 citations

The mouse homologue ofhst/ k-FGF: sequence, genome organization and location relative toint-2

1989 • 51 citations

Fibroblast growth factor receptor-1 mediates chemotaxis independently of direct SH2-domain protein binding

1998 • 51 citations

SHP2 Associates Directly with Tyrosine Phosphorylated p90 (SNT) Protein in FGF-Stimulated Cells

1997 • 51 citations

Analysis of Putative Heparin-binding Domains of Fibroblast Growth Factor-1

1995 • 50 citations

Expression of chicken fibroblast growth factor homologous factor (FHF)-1 and of differentially spliced isoforms of FHF-2 during development and involvement of FHF-2 in chicken limb development

1999 • 49 citations

Transfected MCF-7 cells as a model for breast cancer progression

1994 • 49 citations

Transcriptional and posttranscriptional regulation of urokinase‐type plasminogen activator expression in endothelial cells by basic fibroblast growth factor

1995 • 48 citations

Tamoxifen-resistant fibroblast growth factor-transfected MCF-7 cells are cross-resistant in vivo to the antiestrogen ICI 182,780 and two aromatase inhibitors.

1998 • 47 citations

The K-fgf/hst oncogene induces transformation through an autocrine mechanism that requires extracellular stimulation of the mitogenic pathway.

1991 • 47 citations

Both autocrine and paracrine effects of transfected acidic fibroblast growth factor are involved in the estrogen-independent and antiestrogen-resistant growth of MCF-7 breast cancer cells.

1998 • 45 citations

Neural Transmission: Synaptotagmin is just a calcium sensor

1995 • 45 citations

The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells.

1996 • 44 citations

The Expression Of Acidic Fibroblast Growth Gactor (Heparin-Binding Growth Factor-1) And Cytokine Genes In Human Cardiac Allografts And T Cells

1993 • 44 citations

FRAG1, a gene that potently activates fibroblast growth factor receptor by C-terminal fusion through chromosomal rearrangement.

1996 • 44 citations

A Homeo-interaction Sequence in the Ectodomain of the Fibroblast Growth Factor Receptor

1997 • 42 citations

Characterization of a Novel Member of the FGF Family, XFGF-20, in Xenopus laevis

1999 • 40 citations

Apparent normal phenotype of Fgf6-/- mice.

1997 • 40 citations

Apoptosis of human glioma cells in vitro and in vivo induced by a neutralizing antibody against human basic fibroblast growth factor

1996 • 40 citations

Expression of Fibroblast Growth Factor-2 and Fibroblast Growth Factor Receptor-1 in Thyroid Diseases: Difference between Neoplasms and Hyperplastic Lesions.

1998 • 39 citations

Expression and Possible Functions of the FGF‐5 Gene

1991 • 39 citations

Identification and isolation from bovine epithelial lens cells of two basic fibroblast growth factor receptors that possess bFGF-enhanced phosphorylation activities

1989 • 38 citations

Characterization of a cysteine-free analog of recombinant human basic fibroblast growth factor

1989 • 38 citations

Cloned hst gene from normal human leukocyte DNA transforms NIH3T3 cells

1988 • 38 citations

Direct Activation of Phospholipase C-γ by Fibroblast Growth Factor Receptor Is Not Required for Mesoderm Induction in Xenopus Animal Caps

1994 • 37 citations

Association of Atypical Protein Kinase C Isotypes with the Docker Protein FRS2 in Fibroblast Growth Factor Signaling

1999 • 37 citations

Angiogenic activity of the recombinant hst-1 protein

1994 • 36 citations

Phorbol Ester-induced Transcription of a Fibroblast Growth Factor-binding Protein Is Modulated by a Complex Interplay of Positive and Negative Regulatory Promoter Elements

1998 • 33 citations

MCF-10A cells infected with the int-2 oncogene induce angiogenesis in the chick chorioallantoic membrane and in the rat mesentery.

1994 • 33 citations

BCL-2 Is Upregulated in Human SH-SY5Y Neuroblastoma Cells Differentiated by Overexpression of Fibroblast Growth Factor 1

1999 • 33 citations

Retention of fibroblast growth factor 3 in the Golgi complex may regulate its export from cells.

1993 • 32 citations

Androgen-induced growth factor and its receptor: Demonstration of the androgen-induced autocrine loop in mouse mammary carcinoma cells

1993 • 31 citations

Vascular Endothelial Growth Factor and Fibroblast Growth Factor 5 are Colocalized in Vascular and Avascular Epiretinal Membranes

1997 • 29 citations

Heparan Sulfate Degradation in Tumor Cell Invasion and Angiogenesis

1988 • 29 citations

Expression of fibroblast growth factor receptors in naevus-cell naevus and malignant melanoma

1997 • 28 citations

Cleavage of K-FGF produces a truncated molecule with increased biological activity and receptor binding affinity.

1993 • 27 citations

ASSOCIATION OF ACIDIC FIBROBLAST GROWTH FACTOR AND UNTREATED LOW GRADE REJECTION WITH CARDIAC ALLOGRAFT VASCULOPATHY

1995 • 27 citations

Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization.

1992 • 25 citations

Molecular Modeling and Deletion Mutagenesis Implicate the Nuclear Translocation Sequence in Structural Integrity of Fibroblast Growth Factor-1

1996 • 25 citations

Fibroblast growth factors induce additional limb development from the flank of chick embryos

1995 • 23 citations

The proto-oncogene FGF-3 is constitutively expressed in tumorigenic, but not in non-tumorigenic, clones of a human colon carcinoma cell line.

1995 • 22 citations

SHORT COMMUNICATION: Expression of FGF5 in choroidal neovascular membranes associated with ARMD

1997 • 21 citations

Mouse Mammary Tumor Virus Sequences Responsible for Activating Cellular Oncogenes

1998 • 19 citations

Interaction of bovine epithelial lens (BEL) cells with extracellular matrix (ECM) and eye-derived growth factor (EDGF)

1983 • 18 citations

FGF is an essential regulator of the fifth cell division in preimplantation mouse embryos

1998 • 18 citations

Biosynthesis of Human Fibroblast Growth Factor-5

1991 • 16 citations

HST-1/FGF-4 stimulates proliferation of megakaryocyte progenitors synergistically and promotes megakaryocyte maturation.

1996 • 14 citations

Compensation by Fibroblast Growth Factor 1 (FGF1) Does Not Account for the Mild Phenotypic Defects Observed in FGF2 Null Mice

2000 • 13 citations

Molecular mechanism of androgen-dependent growth in transformed cells. Pathway from basic science to clinical application

1995 • 13 citations

Fibroblast growth factor 5 proto-oncogene is expressed in normal human fibroblasts and induced by serum growth factors.

1991 • 11 citations

Identification of a MMTV Insertion Mutation within the Coding Region of theFgf-3Protooncogene

1997 • 9 citations

Retention of Fibroblast Growth Factor 3 in the Golgi Complex May Regulate Its Export from Cells

1993 • 8 citations

Fibroblast growth factor receptor (FGFR)

2014 • 7 citations

Primary Cell Culture

1994 • 6 citations

Mutation associated with Crouzon syndrome causes ligand‐independent dimerization and activation of FGF receptor‐2

1997 • 6 citations

Structural analysis of a mature hst-1 protein with transforming growth factor activity

1991 • 4 citations

Expression of fibroblast growth factor-5 by bovine choroidal endothelial cells in vitro.

1997 • 4 citations