Intracellular Protein Topogenesis

Intracellular protein topogenesis

1980 • 1,378 citations

International cell biology 1976–1977

1978 • 762 citations

Phosphohexosyl components of a lysosomal enzyme are recognized by pinocytosis receptors on human fibroblasts.

1977 • 580 citations

Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum.

1980 • 502 citations

A hypothesis for I-cell disease: Defective hydrolases that do not enter lysosomes

1972 • 446 citations

The Assembly of Proteins into Biological Membranes: The Membrane Trigger Hypothesis

1979 • 408 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Phosphorylation of mannose residues.

1980 • 404 citations

Recognition and receptor-mediated uptake of a lysosomal enzyme, α-l-iduronidase, by cultured human fibroblasts

1977 • 354 citations

Negative strand viruses and the host cell.

1978 • 328 citations

Secretion of beta-lactamase requires the carboxy end of the protein

1980 • 311 citations

Purification of the fusion protein of Sendai virus: analysis of the NH2-terminal sequence generated during precursor activation.

1978 • 283 citations

A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function.

1978 • 266 citations

Early events in the biosynthesis of the lysosomal enzyme cathepsin D.

1979 • 233 citations

Phosphomannosyl-enzyme receptors in rat liver. Subcellular distribution and role in intracellular transport of lysosomal enzymes.

1980 • 231 citations

Biosynthetic intermediates of beta-glucuronidase contain high mannose oligosaccharides with blocked phosphate residues.

1980 • 225 citations

Chicken ovalbumin contains an internal signal sequence

1979 • 216 citations

The transport of lysosomal enzymes

1977 • 214 citations

Eukaryotic signal sequence transports insulin antigen in Escherichia coli.

1980 • 203 citations

Cell-free synthesis of fish preproinsulin, and processing by heterologous mammalian microsomal membranes.

1977 • 182 citations

A signal sequence is not sufficient to lead β-galactosidase out of the cytoplasm

1980 • 149 citations

Bacteria mature preproinsulin to proinsulin.

1980 • 143 citations

NH2-terminal amino acid sequences of precursor and mature forms of the ribulose-1,5-bisphosphate carboxylase small subunit from Chlamydomonas reinhardtii.

1979 • 142 citations

A membrane component essential for vectorial translocation of nascent proteins across the endoplasmic reticulum: requirements for its extraction and reassociation with the membrane.

1980 • 140 citations

Identification and characterization of a membrane component essential for the translocation of nascent proteins across the membrane of the endoplasmic reticulum.

1980 • 137 citations

An Escherichia coli mutant with an amino acid alteration within the signal sequence of outer membrane prolipoprotein.

1978 • 131 citations

A mechanism of protein localization: the signal hypothesis and bacteria.

1980 • 127 citations

Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes.

1979 • 124 citations

Protein transfer across microsomal membranes reassembled from separated membrane components

1978 • 114 citations

Membrane biogenesis: cotranslational integration of the bacteriophage f1 coat protein into an Escherichia coli membrane fraction.

1979 • 103 citations

Absence of a cleavable signal sequence in Sindbis virus glycoprotein PE2.

1979 • 85 citations

Secretion requires a cytoplasmically disposed sulphydryl of the RER membrane

1980 • 30 citations