Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy.

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

The Endocrinology and Developmental Biology of the Prostate*

1987 • 1,047 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

1992 • 760 citations

Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction

1992 • 625 citations

Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse

1992 • 552 citations

FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.

1991 • 541 citations

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma

1991 • 523 citations

An Essential Heparin-Binding Domain in the Fibroblast Growth Factor Receptor Kinase

1993 • 520 citations

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.

1991 • 443 citations

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1992 • 438 citations

Expression cDNA Cloning of the KGF Receptor by Creation of a Transforming Autocrine Loop

1991 • 427 citations

The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

1988 • 425 citations

Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3.

1991 • 415 citations

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

1992 • 414 citations

The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.

1991 • 406 citations

Developmental expression of two murine fibroblast growth factor receptors, fig and bek

1991 • 397 citations

Nuclear and cytoplasmic localization of different basic fibroblast growth factor species

1990 • 332 citations

Stromal-epithelial interactions in adult organs

1985 • 315 citations

Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary cell culture.

1984 • 315 citations

Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin.

1992 • 287 citations

Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions, and growth factors.

1992 • 279 citations

Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis

1990 • 266 citations

The int-2 gene product acts as an epithelial growth factor in transgenic mice.

1990 • 263 citations

Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3.

1992 • 263 citations

K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes.

1990 • 260 citations

Human keratinocyte growth factor activity on proliferation and differentiation of human keratinocytes: Differentiation response distinguishes KGF from EGF family

1990 • 228 citations

Biological and biochemical properties of fibroblast growth factors. Implications for the pathogenesis of atherosclerosis.

1989 • 228 citations

Fibroblast Growth Factor Receptors from Liver Vary in Three Structural Domains

1991 • 227 citations

Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration.

1989 • 210 citations

Animal models of the hormone-sensitive and -insensitive prostatic adenocarcinomas, Dunning R-3327-H, R-3327-HI, and R-3327-AT.

1978 • 172 citations

A comparative study of the ultrastructure and lack of growth capacity of adult human prostate epithelium mechanically separated from its stroma

1970 • 136 citations

Heparin-binding growth factor gene expression and receptor characteristics in normal rat prostate and two transplantable rat prostate tumors.

1989 • 127 citations

Control of Fibroblast Growth Factor Receptor Kinase Signal Transduction by Heterodimerization of Combinatorial Splice Variants

1993 • 124 citations

The Human Fibroblast Growth Factor Receptor Genes: a Common Structural Arrangement Underlies the Mechanisms for Generating Receptor Forms That Differ in Their Third Immunoglobulin Domain

1991 • 123 citations

The Heparin-Binding (Fibroblast) Growth Factor Family Of Proteins

1989 • 106 citations

Different hormonal requirements for androgen-independent growth of normal and tumor epithelial cells from rat prostate

1987 • 105 citations

Multiple mRNAs code for proteins related to the BEK fibroblast growth factor receptor.

1991 • 101 citations

Mesenchyme-induced changes in the neoplastic characteristics of the Dunning prostatic adenocarcinoma.

1991 • 101 citations

The Human FGF-5 Oncogene Encodes a Novel Protein Related to Fibroblast Growth Factors

1988 • 98 citations

Three forms of rat basic fibroblast growth factor are made from a single mRNA and localize to the nucleus

1991 • 94 citations

Expression and immunochemical analysis of rat and human fibroblast growth factor receptor (flg) isoforms.

1992 • 92 citations

Heparin-binding growth factor/prostatropin attenuates inhibition of rat prostate tumor epithelial cell growth by transforming growth factor type beta

1988 • 80 citations

Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants.

1993 • 79 citations

Development and characteristics of the available animal model systems for the study of prostatic cancer.

1987 • 72 citations

Basic fibroblast growth factor (bFGF), a multifunctional growth factor for neuroectodermal cells

1990 • 67 citations

Influence of male genital tract mesenchymes on differentiation of Dunning prostatic adenocarcinoma.

1990 • 66 citations

In VitroStudies of Human Prostatic Epithelial Cells: Attempts to Identify Distinguishing Features of Malignant Cells

1989 • 54 citations

Expression and transforming activity of a variant of the heparin-binding fibroblast growth factor receptor (flg) gene resulting from splicing of the alpha exon at an alternate 3′-acceptor site

1992 • 49 citations

Growth factor receptors and prostate cell growth.

1991 • 45 citations

Exon Skipping Causes Alteration of the COOH-Terminus and Deletion of the Phospholipase Cγ1 Interaction Site in the FGF Receptor 2 Kinase in Normal Prostate Epithelial Cells

1993 • 37 citations

Characterization of INT-2: A member of the fibroblast growth factor family

1990 • 30 citations

Receptor phenotype underlies differential response of hepatocytes and nonparenchymal cells to heparin-binding fibroblast growth factor type 1 (aFGF) and type 2 (bFGF)

1992 • 26 citations