Keratinocyte growth factor induces angiogenesis and protects endothelial barrier function

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Angiogenesis.

1992 • 2,581 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

The Transcriptional Program in the Response of Human Fibroblasts to Serum

1999 • 1,994 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Fgf10 is essential for limb and lung formation

1999 • 1,204 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

Tumor Induction of VEGF Promoter Activity in Stromal Cells

1998 • 964 citations

Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless

1998 • 869 citations

Purification and characterization of a newly identified growth factor specific for epithelial cells.

1989 • 842 citations

Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.

1995 • 764 citations

Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

1992 • 760 citations

Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells

1998 • 695 citations

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

1994 • 665 citations

Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

1998 • 638 citations

Large induction of keratinocyte growth factor expression in the dermis during wound healing.

1992 • 603 citations

Keratinocyte growth factor is required for hair development but not for wound healing.

1996 • 541 citations

Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis

1994 • 541 citations

The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor

1997 • 529 citations

How Tumors Become Angiogenic

1996 • 514 citations

Intracoronary gene transfer of fibroblast growth factor–5 increases blood flow and contractile function in an ischemic region of the heart

1996 • 484 citations

Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene

1989 • 475 citations

Vascular permeability factor/vascular endothelial growth factor:A multifunctional angiogenic cytokine

1997 • 474 citations

Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality.

1998 • 362 citations

Angiogenesis: a Dynamic Balance of Stimulators and Inhibitors

1997 • 325 citations

Keratinocyte growth factor

1995 • 321 citations

Role of endothelial cell cytoskeleton in control of endothelial permeability.

1982 • 310 citations

Characterization of Recombinant Human Fibroblast Growth Factor (FGF)-10 Reveals Functional Similarities with Keratinocyte Growth Factor (FGF-7)

1998 • 307 citations

SAPK2/p38-dependent F-Actin Reorganization Regulates Early Membrane Blebbing during Stress-induced Apoptosis

1998 • 303 citations

FGF Binding and FGF Receptor Activation by Synthetic Heparan-Derived Di- and Trisaccharides

1995 • 270 citations

Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.

1993 • 263 citations

Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats.

1995 • 256 citations

Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia.

1995 • 211 citations

Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality.

1996 • 206 citations

Basic fibroblast growth factor is internalized through both receptor-mediated and heparan sulfate-mediated mechanisms.

1992 • 198 citations

Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor.

1994 • 185 citations

Progesterone-dependent expression of keratinocyte growth factor mRNA in stromal cells of the primate endometrium: keratinocyte growth factor as a progestomedin.

1994 • 182 citations

Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung.

1995 • 182 citations

VEGF induces hyperpermeability by a direct action on endothelial cells

1998 • 178 citations

Keratinocyte growth factor reduces lung damage due to acid instillation in rats.

1996 • 178 citations

Fibroblast growth factor receptor 2 limits and receptor 1 accelerates tumorigenicity of prostate epithelial cells.

1997 • 174 citations

Keratinocyte Growth Factor: A Fibroblast Growth Factor Family Member with Unusual Target Cell Specificity

1991 • 153 citations

Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation.

1998 • 149 citations

Permeability of human endothelial monolayers: effect of vasoactive agonists and cAMP

1989 • 128 citations

Fibroblast growth factor receptors display both common and distinct signaling pathways.

1995 • 125 citations

Angiogenesis by fibroblast growth factor 4 is mediated through an autocrine up-regulation of vascular endothelial growth factor expression.

1997 • 123 citations

Structure and Expression of Human Fibroblast Growth Factor-10

1997 • 122 citations

Developmental and Hormonal Regulation of Keratinocyte Growth Factor Expression and Action in the Ovarian Follicle*

1998 • 121 citations

Altered expression of keratinocyte growth factor and its receptor in psoriasis.

1997 • 108 citations

Keratinocyte growth factor increases transalveolar sodium reabsorption in normal and injured rat lungs.

1997 • 99 citations

Expression of biologically active recombinant keratinocyte growth factor. Structure/function analysis of amino-terminal truncation mutants.

1993 • 96 citations

Heparan sulfate proteoglycans as transducers of FGF-2 signalling

1994 • 94 citations

Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice.

1996 • 91 citations

Internalization of basic fibroblast growth factor (bFGF) in cultured endothelial cells: Role of the low affinity heparin‐like bFGF receptors

1993 • 90 citations

Intravenous keratinocyte growth factor protects against experimental pulmonary injury

1998 • 83 citations

Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin-mimicking polyanionic compound.

1997 • 81 citations

The platelet endothelial cell adhesion molecule‐1 (PECAM1) contributes to endothelial barrier function

1995 • 81 citations

Comparative Study of Hepatocyte Growth Factor/Scatter Factor and Keratinocyte Growth Factor Effects on Human Keratinocytes

1995 • 80 citations

KGF prevents hydrogen peroxide-induced increases in airway epithelial cell permeability

1997 • 77 citations

Differential effect of cell-associated heparan sulfates on the binding of keratinocyte growth factor (KGF) and acidic fibroblast growth factor to the KGF receptor.

1994 • 75 citations

Assay and purification of naturally occurring inhibitor of angiogenesis

1991 • 73 citations

Expression of keratinocyte growth factor in embryonic liver of transgenic mice causes changes in epithelial growth and differentiation resulting in polycystic kidneys and other organ malformations.

1996 • 72 citations

Inflammatory agonists that increase microvascular permeability in vivo stimulate cultured pulmonary microvessel endothelial cell contraction

1990 • 71 citations

Keratinocyte growth factor decreases pulmonary edema, transforming growth factor-beta and platelet-derived growth factor-BB expression, and alveolar type II cell loss in bleomycin-induced lung injury.

1998 • 70 citations

The role of cadherin endocytosis in endothelial barrier regulation: involvement of protein kinase C and actin-cadherin interactions.

1998 • 65 citations

H2O2and Genistein Differentially Modulate Protein Tyrosine Phosphorylation, Endothelial Morphology, and Monolayer Barrier Function

1998 • 54 citations

Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways.

1998 • 50 citations

TYPES OF PULMONARY MICROVASCULAR INJURY

1982 • 49 citations

Effects of keratinocyte growth factor (KGF) on gut growth and repair

1998 • 44 citations

Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries

1997 • 42 citations

Barrier Function of Airway Epithelium: Effects of Radiation and Protection by Keratinocyte Growth Factor

1998 • 42 citations

Keratinocyte Growth Factor Stimulation of Gelatinase (Matrix Metalloproteinase-9) and Plasminogen Activator in Histiotypic Epithelial Cell Culture

1995 • 42 citations

Modulation of barrier function of bovine aortic and pulmonary artery endothelial cells: dissociation from cytosolic calcium content

1992 • 40 citations

Angiogenic activity of the recombinant hst-1 protein

1994 • 36 citations

MCF-10A cells infected with the int-2 oncogene induce angiogenesis in the chick chorioallantoic membrane and in the rat mesentery.

1994 • 33 citations

Spatially restricted expression of fibroblast growth factor-10 mRNA in the rat brain

1997 • 28 citations

A Truncated K-sam Product Lacking the Distal Carboxyl-Terminal Portion Provides a Reduced Level of Autophosphorylation and Greater Resistance against Induction of Differentiation

1995 • 25 citations

Mammogenic Hormones Differentially Modulate Keratinocyte Growth Factor (KGF)-Induced Proliferation and KGF Receptor Expression in Cultured Mouse Mammary Gland Epithelium¹

1998 • 18 citations