Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.

THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY

1963 • 10,322 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Neural and developmental actions of lithium: A unifying hypothesis

1989 • 1,005 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Mesoderm induction in early Xenopus embryos by heparin-binding growth factors

1987 • 953 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1985 • 738 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254

1991 • 583 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1992 • 480 citations

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

1985 • 458 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.

1991 • 443 citations

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1992 • 438 citations

Function of Ras as a molecular switch in signal transduction.

1992 • 425 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

1992 • 414 citations

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

1987 • 353 citations

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

1993 • 328 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

The structure of Ras protein: a model for a universal molecular switch

1991 • 310 citations

Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex.

1993 • 291 citations

Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.

1991 • 272 citations

The effect of fibroblast growth factor on PC12 cells

1985 • 270 citations

Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma.

1992 • 231 citations

Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor

1993 • 224 citations

Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade.

1992 • 219 citations

Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively.

1993 • 211 citations

Involvement of p21ras in Xenopus mesoderm induction

1992 • 207 citations

Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

1990 • 195 citations

Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target

1993 • 189 citations

Lithium-induced teratogenesis in frog embryos prevented by a polyphosphoinositide cycle intermediate or a diacylglycerol analog

1989 • 185 citations

Differentiation factors, including nerve growth factor, fibroblast growth factor, and interleukin-6, induce an accumulation of an active Ras.GTP complex in rat pheochromocytoma PC12 cells.

1992 • 185 citations

Effect of Phospholipase C-γ Overexpression on PDGF-induced Second Messengers and Mitogenesis

1990 • 170 citations

NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation

1991 • 152 citations

Expression of acidic fibroblast growth factor cDNA confers growth advantage and tumorigenesis to Swiss 3T3 cells.

1988 • 149 citations

The beta-PDGF receptor induces neuronal differentiation of PC12 cells.

1992 • 145 citations

Calcium-Dependent Nerve Growth Factor-Stimulated Hydrolysis of Phosphoinositides in PC12 Cells

1987 • 127 citations

Nerve Growth Factor Stimulation of the Ras-Guanine Nucleotide Exchange Factor and GAP Activities

1992 • 120 citations

Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.

1993 • 99 citations

Alterations of Lipid Metabolism in Response to Nerve Growth Factor

1982 • 97 citations

Epidermal growth factor stimulates the tyrosine phosphorylation of SHC in the mouse.

1993 • 95 citations

Induction of Neurite Formation in PC12 Cells by Microinjection of Proto-Oncogenic Ha-ras Protein Preincubated with Guanosine-5′-O-(3-Thiotriphosphate)

1987 • 95 citations

Lithium-Sensitive Production of Inositol Phosphates During Amphibian Embryonic Mesoderm Induction

1992 • 94 citations

The neurite-promoting effect of fibroblast growth factor on PC12 cells

1983 • 88 citations

Production of 1,2‐Diacylglycerol in PC12 Cells by Nerve Growth Factor and Basic Fibroblast Growth Factor

1990 • 57 citations

Differential effects of carboxy-terminal sequence deletions on platelet-derived growth factor receptor signaling activities and interactions with cellular substrates.

1992 • 31 citations

Carbachol stimulates a different phospholipid metabolism than nerve growth factor and basic fibroblast growth factor in PC12 cells.

1991 • 26 citations